Database of mammalian genes
Home

Home Search Browse Statistics User guide FAQs Links Questions Contribute Download


Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PSMD4 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5710
Official gene symbolPSMD4
Full nameproteasome (prosome, macropain) 26S subunit, non-ATPase, 4
Aliases,AF,AF-1,ASF,MCB1,Rpn10,S5A,pUB-R5,
Gene summaryThe 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21. [provided by RefSeq]
LocationChromosome: 1   Locus: 1q21.3
Gene position151227197 - 151239955  Map Viewer
Gene orientationplus
Gene size12759 bp
Gene sequence
OMIM ID601648