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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for C12orf5 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID57103
Official gene symbolC12orf5
Full namechromosome 12 open reading frame 5
Aliases,TIGAR,
Gene summaryThis gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq]
LocationChromosome: 12   Locus: 12p13.3
Gene position4430359 - 4469194  Map Viewer
Gene orientationplus
Gene size38836 bp
Gene sequence
OMIM ID610775