Database of mammalian genes
Home

Home Search Browse Statistics User guide FAQs Links Questions Contribute Download


Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PAK7 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID57144
Official gene symbolPAK7
Full namep21 protein (Cdc42/Rac)-activated kinase 7
Aliases,KIAA1264,MGC26232,PAK5,
Gene summaryThe protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq]
LocationChromosome: 20   Locus: 20p12
Gene position9819687 - 9518037  Map Viewer
Gene orientationminus
Gene size301651 bp
Gene sequence
OMIM ID608038