| Entrez gene ID | | 5716 |
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| Official gene symbol | | PSMD10 |
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| Full name | | proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 |
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| Aliases | | ,dJ889N15.2,p28, |
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| Gene summary | | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20. [provided by RefSeq] |
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| Location | | Chromosome: X Locus: Xq22.3 |
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| Gene position | | 107334874 - 107327435 Map Viewer |
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| Gene orientation | | minus |
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| Gene size | | 7412 bp |
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| Gene sequence |
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| OMIM ID | | 603480 |
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