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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PSMD12 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5718
Official gene symbolPSMD12
Full nameproteasome (prosome, macropain) 26S subunit, non-ATPase, 12
Aliases,MGC75406,Rpn5,p55,
Gene summaryThe 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3. [provided by RefSeq]
LocationChromosome: 17   Locus: 17q24.2
Gene position65362721 - 65336619  Map Viewer
Gene orientationminus
Gene size26103 bp
Gene sequence
OMIM ID604450