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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for KIR2DL5A (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 57292 Official gene symbol KIR2DL5A Full name killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A Aliases ,CD158F,KIR2DL5,KIR2DL5.1,KIR2DL5.3,KIR2DL5B, Gene summary Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq] Location Chromosome: 19   Locus: 19p13.3 Gene position 86691 - 96155  Map Viewer Gene orientation plus Gene size 9465 bp Gene sequence >KIR2DL5A:86691..96155:Length=9465 CTGTGCGCTGCTGAGCTGAGCTGGGGCGCGGCCGCCTGTCTGCACCGGCAGCACCATGTC GCTCATGGTCATCAGCATGGCGTGTGTTGGTGAGTCCTGGAAAGGAATAGAGGGAGGGAG TGCGGGGATGGAGATCTGGGCCCAGAGGTGGAGATATAGGCCTGGAGGTGGAGTTATGGG CCTGGAGTGGAGATCTGGGCCTGGAGTGGATATATGGGCCTGGAGATGGAGTGATGGGCC TAGAAGTGGAGATCTGGGTCTGGAGTGGAGATATGGGCCTGGAGGTGGAGATATGGGCCT GGAGTGGAGATCTGGGCCTGGAGTGGAGATAGGAACCCGGAGGGGAGATAGGAGCCTGGA GTGAAGATATTGGCCTGGGATGGAGATATGGGCCTGGAGTGGAGACATGGGCCTGGAGGT GGAGATATGGGCCTGGAGGTGGAGATATGGGCCTAGAGGTGGATATCTGGGCCTGGAGTG GACATATGGGCCTAGGATGGAGATATGGGCTTGGGGTGGAGATATGGGCCTGGATTGGAG ATATGGGTCTAGGGTGGAAATATTGGCCTGGAGTGGAGATATGGGCCTGGAGTGGAGATA TGGGCTTGGGGTGGGGATAGGGGCCTGGGGTGCGGATATGGGCCTGGAGGCTGGGTCTCT ACACAGCCGACAGCCCTGTTCTTGGGTGCAAGCAGGCACTGAGGGTGAGTTTCCCTTCAG CCCAGCAAGGGCCTGGCTACCAAGACTCACAGCCCAGTGGGGGCAGCAAGGGAGTCCTGG TTTGCCTGCAGATGGATGGTCCATCATGATCTTTCTTTCCAGGGTTCTTCTTGCTGCAGG GGGCCTGGACACATGAGGGTGAGTCCTTCTCCAAACCTTCGGGTGTCATCTCCCCACATA AGAGGATTTTCCTGAAACAGGAGGGAAGCCCGGTGGGGGATTTTCTTATAAACAAGGATG AGGAGACCCTGGGGTGCTCAGCCCACAGTTCCGACCTTGCCCTCCCCAGCCTTCCTTTCC CTTGGCTGAGTCAGGTTCTGTGGGAACCCGGGAGGGTAGACTGGGGTCCTCCAAGCTGGG CTGTGCGGCTGGGATGTGGTGTCACTGGCAGAGGAAGGGAGCAAAGCAGTGCTAGGAACA GCAGGCCTCTGAGGACAAAGGTGTAACTCACACCCTCCAGCGTTTCCATGACGGTAGGGG CTGCAGTGTGGCTGCTGTCATTCTACCTCAGAGGTGGGGGAACCCCAGCCAGGGCCCTGA CCTTCCAAATCCTCTGTTGGGGGCTCAGTTGTGTATTGTGGTTCACACATTGGCTGATAT TCCATTCACAAAGAACATGCCCTCGACCCCATGTCTATTTGTGTTGTTTTATGTGAGTAA TCTTGCAGTATTAAAATCTAGTAGGAGTCCCTTACTCAGCACTTGCTCAAAGTTCTCAGC TGACACTTTTGTTGTAGAGAGACGCCAAGTCTATGCGGGGTGGGTCCTTCCCGTACCCAT GGGCACCCAAGTGTGGTAGGAGCCTTAGAAACGAGGAAAGTGGGGAGAATCTTCTGAGCA CTGGCAGGGAGGGGCGGCTCCACATCCTCCTTTCTAAGGTGGCGCCTCCTTCTCCCCCAG GTGGTCAGGACAAGCCCTTGCTGTCTGCCTGGCCCAGCGCTGTGGTGCCTCGAGGAGGAC ATGTGACTCTTCTGTGTCGCTCTCGTCTTGGGTTTACCATCTTCAGTCTGTACAAAGAAG ATGGGGTGCCTGTCCCTGAGCTCTACAACAAAATATTCTGGAAGAGCATCCTCATGGGCC CTGTGACCCCTGCACACGCAGGGACCTACAGATGTCGGGGTTCACACCCACGCTCCCCCA TTGAGTGGTCAGCACCCAGCAACCCCCTGGTGATCGTGGTCACAGGTCAGAGGACTCATG TCTGGGCTTCTCCTTCTCCCACTTCCTGAATCCCAGAGCATCTGGTGGGGGTGTCCACCA GGGTCCAATCATCCAGGCCCTGACTGTATTTGGTGTCAATGGGGATTGAATACAGGGGAA TGGGTGCTGTGGTGGAAAGAGTAACTGTCGGCAGCATGGCTATATTGTAATCCTTGGAGC CTGTGACTATTTATGTTATAGGACATGGGACTGAAGGGGAAGATGGAGTTCAGGTTGTTG ATGAGTTGACCTTGAGATGGGGAGACGACCTGGACTCTCCCACTGGGCTCAGTGTAATCA CAAGGGTCCACATGAGAGGAGGAGGAAGAGGAGAGTGGGGATTAGAGCAGCGTAGTGGGA GGGAGAGTCCACCAGCCACTGCGGGCTTTGAAAGTGGAGGAAGGCCAGAAGCCACGGAAT GCAGGTGGCCTTTAGGGGCTGGAGAAGTCAATGGAACTGATTCTCCCGAGTCTCCAGAGG GAATGCAGCCCTGCAGATGCCTTGATTGTAGCCCAGGAAGAACAGGGTCTGATTTCTGTC AACAGAAGTGTTCTCTCCCGCCGCCGTGTTTGTGATAATTTTCTGCAGCAACAACAGGAA ACAACACAGGAATCCAGGTCAAGGACAAGTTAAAAAACCAAACAAGAGGGTTGGCTACCC TAAGGTCAGCAAGGGTGCACTGCTGATGCCACCACCAGGCTGGAGCCGCATAGGGAGGGA TCCACAGGGAGAGTCGGGGGTGGAGGGTGAGAGAGAGAGAGAGCATTAGGTCATAGAGCA GGGGAGTGAGTTCTCAGCTCAGGTGTGAGGGGAGCTGTGACAAGGAAGAACCTCCCTGAG GAAACTGCCTCTTCTTCCAGGTCTATTTGGGAAACCTTCACTCTCAGCCCAGCCGGGCCC CACGGTTCGCACAGGAGAGAACGTGACCTTGTCCTGCAGCTCCAGGAGCTCATTTGACAT GTACCATCTATCCAGGGAGGGGAGGGCCCATGAACCTAGGCTCCCTGCAGTGCCCAGCGT CAATGGAACATTCCAGGCTGACTTTCCTCTGGGCCCTGCCACCCACGGAGGGACCTACAC ATGCTTCGGCTCTCTCCATGACTCACCCTATGAGTGGTCAGACCCGAGTGACCCACTGCT TGTTTCTGTCACAGGTGAGGAAAGCCCATGCCTGTCCCATGTCCTGTGATCCTAGAGCCT TAGCTGAGGAGCTTCCTGCTGATGATGGAGAGAAGCATGGACAGATGCAGAGAGAACACG CAGCATGGTGTGAGGGAGGGATCAGGGCACAGGATGGCAGACAGGGCACCTCCAAACCCT CCTGCACGGCCTGCATGGAGGCCCGCGGCCAGGGCTCCAGGCACCCAGGCAGATGGAGAA AGTGGTCAGGACAGACCCAGAGGAGGGAGACTCGGCTCAGTTTGGGGAGATCAGAGGCTC CCTCAGACCCTAAACCTTACCCATTTCCCAGAAGCCCATACTGGCCTCTCACCCACACAG AGATGTCATCACCAGCAACCCCTACACCCTTTTCTTTCCGTTTGAAAAAACATTTATTTA GGTTAAATGTAACTATATAATTTGCCACCTTTACCATTTTTAAAAGTAAAATCTAGTGGT CATAAATTCCTTTATATGCAGGGTGCAGTGGCTCACAGTTATAATCTCGGTGCTTTGAGA GGCCAAGGAAGGTGGATCATTTAAGATCAGAGGCTCGAGATCAGCCTGGCCAACATGAGG GAAATTCATCTTTACTAAACAGACAAGAAAAATTGGCTGGGCATGCTGGCATGCACCTGT ATTCCTAGCTACATGGGAGGCTGAGGCAGGAGAAGTACGTAAGCCCAGGAGGCAGAGGTT GCACTGAGCTGAGATCAGGCCACTGCACTGCAGCCTGGGAGACAGAGAGAGATTCTGTCT CTAAATAAATAAATACATCTATATTCTTTTTTATTGTTGTTGTTACACTCCACCCTTTAC TTCCTGCCCTCTGGTAGCCACCATTCTACTCTCTACCTTCATGAGATCCACCTTTTAGCT CCTGTATATGGGTGAGAAATGGGAATCTTTGCAATGACCTCCAGTTCCATCCATGTGGCT GCAAATGTCAGGATGTTATTCTTTCTACGGATGAGTACTCTCCACTGTGTGTGTGTACTA CATTCTCTCTATCCATTCACCCACTGACGGGCAGGTAAGTTGACTCCACATCTTGGCTAC TGTGAACAGTGCTGCACCAATCGTATGAGTGCAGATATCACTTCGATACACTGATGTCCT TCCCTTTGGGTTTACACCCAGTAGTGGAATTGCTAGATCCTATCAACAGGGTACCAGGGT TCTCCTTTCTCTACCACCTTGCCAGCATTTATTTTGTCTGTGTTTCAGATAAAAGCCACT TTAATGGGATGAGATGATAGCTCACTGTGATTTCAATTGGCATGATTAGTGATACTGAGC ACTTTTTCATGTACATGTTCGCCATTTGTACGTTTTGTTTGTTGAGAAATGTCTGTTCAG GTCTTTTACTAATTGTTAAATTAAATTCATTGTTTTATACCGTTGCTTGAGTTTTATGTA TATTCTAGTTATTAATCCCCTCTCAGATGCATACTTCACAAATATTTTCTCCCAATTTGT CTCTTCTTCACTTTGTTGGTTGCTTCCTTTGCGGTGCAGAAGCTGCTTACTTTGATGTAA TCCCGAAGGTCTATTATTTTGTTTTGATTTCTTGTGTTTTTGAGATTTCAAATAAAATGT CTTTCCTCAGACAAATGTCCTGGAGCATTTCCCCACTCTTTCCTTTTAGACGCTTAATGG TTTCAGGCCTTAAGTGTTTCTTCCATTTTCATTTGATTTCTGTGTATGGTGAGAGGTAGA GGTGCAGTTTCATCAACTGCATGTAGATACCAGTTTTCCCTGCTCCATTTATTGAAAAGA CCGTCGTTTCCTGATTGCAGGTTCTTGGCACGTACAATCGTCAAAGTCCATTGGATGTGA ATGCATGAATTATATCTGTGTTCTTCATTCTGCTCCATTGCTCTAAGGGCCTTTATGCCA ATGTCATGCTGTTGTGCTTACTACAGCTTTGTAACATATTTTTAAGTCAGGGAGTGTGAG GCCTCCAGCACCTGTTTTGTCTTTATACCTCGAAATCTCAGGACACTGGGCATCATTTAA CAATGATGATGGAGAAGGGGACGCCAGGACTCCTAGGGCCCAACATTAGATAACAGAGTG TTGGCCATGAACCAACCTCAAAGATTTCCTTTGAGTAGAAGACAGGCATCCTCATTTCCT CACCTCTCTCCTGTCCTGTGTTCTAGGAAACTCTTCAAGTAGTTCATCTTCACCCACTGA ACCAAGCTCCAAAACTGGTGAGTAAAGATCCCTCTTATCTCTGCTTTTGGAAACCTGGGG AGGTTGGTATCTTGGATTCAAGCATTGGCTCAGCACCTCCCAGCTCTGTGATTGTGGGCC TGTCTTCTAACATCTCTGACCCCCAGACACTACAACAGCGAAGGGTATCTGAGGACAGCA AAGGGCTCAGTGAAGTCTCTTCATTTCAAATTTCTGCAGCTGAGACCTCCTCCAAGCTAG ACGGACGAGTACAAATCTGACATCCTTCTCAGGGATAAAGTGGTGTTTTTTCTGCCTGCA TTCCAAATTGGAGGATAAATTTGAGGGGACTTGAGAGAGGGAGGGGAAGGGAACATCTGA TGAGGGAAAGGTGATTTAGAGAAGTTCCACTTGCCAAGGAATGAGCCCCTGTTGGTCATG ATGCGACCTTGGCTGAGTCAGCAGAGCAAGAGCCTTGCAGTAAGAAGGAACGTAGTTCAT CCACAAATATGACACTTCCACTTACTCACTTATTCAGCCACTGCCCTGTGCTCTGACTGT ACAGTGTGGAACCCTTTCCTGCTGTTGCCATAATAAATCTCCACAATCTTCATGGATGAC AACAACACAGCTTTTAAAATTATCTTACAGTGTTATAGCTCAGAAATATGAAATGCATTT CACTGGGCTAAAATCAAGGTGACTGCGAGGCTGCCTTTTCTCTGAAGGTTCCAGGCGAGA ATCGGCTTTTCACATTTCCCAGCTCCCAGAGGTTCCCACGCTCCTTGGCATCTGGTCCCC ATCCTCCTTCCTCGAAGCCCACAAAAGCTCATCACATCTCTCACGTGGCATCACTCAGAT CCCTCTTCCTTACCTCACCTCTTTCTCTAAGTGTTGCTCTGACTTTTTCTTCCTCTTTTA AAGACTTTGGGATTCTATTGAGTTTACCAAGATAATCCATCACAATCTCCCTAAAATCAC CCAAGATAACCTCTTTTTAAGTTCAGCTGATTAGCAACCATAATTCCATCTGCAATCTTT ATTCCTCCTTTCATGTAAAATAACATATTCACAAGCTATGGAGGCTAGGACAGGGACATT TTGGGGGTGGGCCAGCATTCTCCTGCCTTCCACAAATGGTAAACACGATGCATTTGGCCT CTGCTCTTAGGACACTGACATTGCAGATGGGCAAATGGGAGGGCAGAATATGAATGCACA AGTGGACCAGTAATGATTGATCCATTGGGAAGCATCCGTGCATGAAATCTATTTACCTAT TTATTTATCTATTTATCTATTTATGTATTTATTTATTTGCGGCGAAGTCATTCTCTGTCC CCGGGCTGGAGTGCAGTGGCATGACCTCAGCTCACCACAACCTCCGCCTCCCGGGTTCAG GCGATTCTCCTGCCTCAGCCTCCTGACTAGTTGTGATTCCAGTCCCCTCCACCACACCCA GCTAATATTCTTTTATATTTTTTAGTAGAGATGGAGTTTCACCATGTTGCGCAGATTGTC TCCAACTCCCAACCTCAAGTGATCCGACCGTCTCAGCATCCCAAAATGCTGGGACTCAAG GTGTGAGCCACTGCGCCCAGCCGAAATTTAAAATAAATAATAAAGAATTCTAAGTGTATA ATTTCAGGAGACAGAGAAAGTCTCACTAATCAGATAATATTTGTGACCATAATGAAAAAA AAAAGTAGATTCAACCCCTGGAAGATTGGCGGAAGGATTTTCCACACACAGCTGTCAGCC GTGAAGGCACAAATGTGAAAACAATCTGATGTGGAAGGAAGAGGCTCTGCATTCAAATGC TGGGAATGAAGTGGGGAGAATGACAAGACGACTGTGGAGAGACGGAGAGCACTCTGGGTA CACAGGAAACTAAGGAGGAACAAGGAGCGTGTGTTTGACACTCACAGCCATTGGATTCAC CTCGGGGTAGCCAGGAATCCCTACATGATTAATATGACTGACATGAAAATAAGGACGCCC AAGTGCGTAACTGGAATCTAGGAGACCGTGGAAAAGGCAATTCCCGCCCCACTGGTGAAA TGTGGTGCTGATTTAGACACTAAATGAATGAAGTAGATGGGTATAAGATATGTCTGTGAG GTAGAATCATTTGTAGGGAGGGCTTGCTGGATTTGATAATGCCTACTTATTTAATTTTGA ATATATTAATTTCTTTCTGAGATTTATTTTTCCTACATGTAAATCAATATCTGGCAGAGG AGTGATTGATAGATAGATGAGGGGTGGTGCAAATGAAGGGACTTATTATAGCATAATATA CAAGTCTGTGAATGGGAGCTTACGCCTGTAACCCAACACTTTGGGAGGCCAAGGCGTTTG GATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGAGAAACCCCATGCTCT TTTTAGCAACCAGTCCTAGGGACCTCATGGAGAACTTGCCAACCACGTCTCATGGGGACA GCATTAATGTATTCATGATGGATCCACCCCCATAACTGGAACGTCTCTCAATAGGCCCAG CCTCCCACACTGCGAGATAAGTGTCAACGTGAGGTTTGGCGGGGTCAAACATCCAAACTA TAGCAGTGGTATCCCCAGCATGTTCTCTGATTATTTTGAGAACTATAACTGAGAAAGCAG GAGAAAGCTGGGTATCCTGCCATCGGGGAACTTGTCCTAAACAGATGTTGTATGTGCTTA GCTGGCAACCAAGAAATGAGAGACAATCCATAAAGAGGAACTGCTATAATTAGCTTCTTA TTGGATTCCCACCTTCCCCCAGGTATCCGCAGACACCTGCACATTCTGATTGGGACCTCA GTGGCTATCATCCTCTTCATCATCCTCTTCTTCTTTCTCCTTCATTGCTGCTGCTCCAAC AAAAAGAGTAAGTCTCACGAAGCAGAGGTCAGAGAGCTCAGGACCATGTGGGGAAGCAGG ATGGGAGCACACTGGTGTGTGTTCCTGACTGGCAGGATGGTCCCTGGACCAAGGCAGGAG CCACAGAGGCAGGGCTTTCTAGAGAGAGCACCAGACACCCTGCCCCTGCCTTCAGCTCAC AGACCATTGCCTGATTCTGAACTGTATCCTCACGTCCCCTGCAGCCACTGACATCCAGGA GAAGGTTCCATGACAGGCAGAAAGGGGAGACAGAATCACTGGGATGGGAACTCAGAGCTA TTCATGGGATGGGTCCTTGAGCTCAGAGAGATAGAATGTCTGGGTCTGGCTGATGACAGC TGAGGGACCTCAGGCACCTACGGCCTCCCGCTGTGTGTTGGTGTCTGCTCATGAAATGAG GACCCAAAAGTGCCCTTCCAGCTGTTTTGATGACTTCTATCTCCTACAGATGCTGCTGTA ATGGACCAAGAGCCTGCCGGGGACAGAACAGTGAACAGGGAGGTAGGTTCTCCTCAGCCC AGCCTCATGGATTGAGTCTCATTCCCTAATAGTCTTGAAGAATGTGAGCACCCTCCCTCA CTCAGCATTTCCCTCTCTCCAGGACTCTGATGATCAAGACCCTCAGGAGGTGACATATGC ACAGTTGGATCACTGCGTTTTCACACAGACAAAAATCACTTCCCCTTCTCAGAGGCCCAA GACACCTCCAACAGATACCACCATGTACATGGAACTTCCAAATGCTAAGCCAAGATCATT GTCTCCTGCCCATAAGCACCACAGTCAGGCCTTGAGGGGATCTTCTAGGGAGACAACAGC CCTGTCTCAAAACCGGGTTGCTAGCTCCCATGTACCAGCAGCTGGAATCTGAAGGCATCA GTCTTCATCTTAGGGGATCGCTCTTCCTCACACCACAAATCTGAACATGCCTCTCTCTTG CTTACAAATGTCTAAGGTCCCCACTGCCTGCTGGAGAGAAGACACACTCCTTTGCTTAGC CCACAATTCTCTATTTCACTTGACCCCTGCCCACCTCTCCAACTGAACTGGCTTACTTCC TAGTCTACTTGAGGCTGCAATCACACTGAGGAACTCACAATTCCAGACATACAAGAGGCT CCCTCTTAACATGGCACTGAGACACGTGCTGTTCCACCTTCCCTCATGCTGTTTCACCTT TCCTCAGACTATTTTCCAGCCTTCTGTCAGTCAGCAGTGAAACTTATAAAATTTTTTGTG ATTTCAATGTAGCTGTCTCCTTTTCAAATAAACATGTCTGCCCTC OMIM ID 605305