Database of mammalian genes
Home

Home Search Browse Statistics User guide FAQs Links Questions Contribute Download


Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PTGER4 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5734
Official gene symbolPTGER4
Full nameprostaglandin E receptor 4 (subtype EP4)
Aliases,EP4,EP4R,MGC126583,
Gene summaryThe protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq]
LocationChromosome: 5   Locus: 5p13.1
Gene position40680032 - 40693837  Map Viewer
Gene orientationplus
Gene size13806 bp
Gene sequence
OMIM ID601586