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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for HAMP (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 57817 Official gene symbol HAMP Full name hepcidin antimicrobial peptide Aliases ,HEPC,HFE2B,LEAP1,PLTR, Gene summary The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq] Location Chromosome: 19   Locus: 19q13.1 Gene position 35773410 - 35776046  Map Viewer Gene orientation plus Gene size 2637 bp Gene sequence >HAMP:8041628..8044264:Length=2637 GACTGTCACTCGGTCCCAGACACCAGAGCAAGCTCAAGACCCAGCAGTGGGACAGCCAGA CAGACGGCACGATGGCACTGAGCTCCCAGATCTGGGCCGCTTGCCTCCTGCTCCTCCTCC TCCTCGCCAGCCTGACCAGTGGCTCTGTTTTCCCACAACAGGTGAGAGCCCAGTGGCCTG GGTCCTTAGCAGGGCAGCAGGGATGGGAGAGCCAGGCCTCAGCCTAGGGCACTGGAGACA CCCGAGCACTGAGCAGAGCTCAGGACGTCTCAGGAGTACTGGCAGCTGAACAGGAACCAG GACAGGCACGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGTTGAGGCAGGCAGCC CACTTGAGGTCAGTTTGAGACCAGCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAA ATACAAAAGTTAGCCAGGCTTGGTGGCAGGTGCCTGTAATCCCAGCTACTCGGGAGACTG AGGCAGGAGAATTGCTTGAACCCGCAAGGTGGAGGTTGCACAGTGAGCTGAGATTGCACC ACTGCACTCCAGCCTGGCAACAGAGCAAGACTCCATCTCCAAAAAAGAACAGAAATCAAT GAAGCACCGAGTGACAGGGACTGGAAGGTCCTAATTCCATGGGTATTTACGGAACCCCTA CGCCGTGTGGAGTCTTATTCTAGACAGTGGGGACGAGGCCATGAACAAGGTAGATGAGAG AGGAGATTTCTCCATCCTGGTCAGGGAATTTGTTAAAGACTGATGAAAACATGAATAAAT AATTGTGTCTAGTACATTCTATTCGTGAATCTCATAACAGACAGTGGTAGAGTGACCGTG ACCCATTCGCCACACAGTAGAGTCACTTTTTTGGTTTGTTTTTTAGAGACAGGGTCTTCC TCTGTTGCTGAGGCTGGAGTGCAGTGGTGCAGTCATAGTTCACTGCAGCCTCAACCTCCT GTGCTCAAGCAATCCTCCCACCTCAGCGTCCCAAGTAGCTGGGACAGCAGGCACATGCCA CGGGTTGGGGGACCACAGGCATGGTCAAGGGGCTGGCAGTCAAGCAAGTGTTTCATGAGA AAGTGACAGTTGACCTTCGTCTTGGAGGGTGAGAGATGGAGGCAGCAAAGACCTAAGGAG AGGACAAGCCAGCATAGCCCAGGGTCAGGCTGAACAAGAGGAGATGGTGGGACTTGGGGA TAAGGCTGAGGGGTGGGCAGTCCCTAAGTCTTGTGGGCAACCATGCAGACACTGATTTTT CCTTGGAATAAAGAGGAAGCCCCCATAAGCTTTTTTTTTTTTTTCTGAGATAGGGTCTCG CTCTGTCGTTCAGGCTGGTGTGCAGTGGCATCATCTGGGCTCACTGCAACCTCCGCCTCC CGGGTTCAAGCAATTCTCCTGCCTCAGCTTCCCGAGCAGCTGGGATTACAGGCGGCTGCC ACCACGCCCGGCTAATTTTTGTTTTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGA CTGGTCTTGAACTCCTGACCTCAGGTGATTCTCCCACCTCGGCTTCCCAAAGTGCTGGGA TTACAGGCGTGAGCCACTGCGCCCAGCCTCCTGTAGGTTTTTAAAATGGAGAAAACCACA ATCTCACTGGCCATGTTTTAAAAAACTTAATCTGCCAGTCAGGCACCATGGCTCACACCT GTAATCCCAGAGTTTTGGGAGGCCAAGGTAGGAAGATCAGTTGAGCCCAGGAGTTCAAGA CCAGCTTGGGCAACACAACCAGACCCCACCTCTACAAAAAATTAAAAAATTAGCCGGGTG TGGTGGCGTGCACCTGCTGTCCCAGCTACTCGGGAAGCTGAGGCGGGAGCATCGCTTGAG CACAGGAGGTCAAGGCTGCAGGGAGCTATGACTGTGCCACTGCACTCTGGCCTGGGCAAC AGAGGAAGACTCTGTCTAAAAAACAAACAAAAAAAGTGACTCTGCTGTGTGGCAAATGGA TTGAGGGGCAAGAATGCAGGGAGGTGTGTTAGGAGGCTGGCACTGGCATCCAGGCAGGGG AAGGTGATATCCCAAAGAAGAGTAGCAGCTGTGGAAAGAGGAGGAGGCGGATCTGGGAGG TTTTTTTTTTTAGGAAAAGCCGCCCATGGGAAGGTGAGCAGAAGCAAGAAAGCAAGGCCC CTCCTAAGAGTCCATTTGAGCTCTGGGTTTAAACCACTTGGAGAGGAGCAGGTTGCCGGG AGCCAGTCTCAGAGGTCCACTGGGCCCCCTGCCATCCTCTGCACCCCCTTCTGCTTTCAC AGACGGGACAACTTGCAGAGCTGCAACCCCAGGACAGAGCTGGAGCCAGGGCCAGCTGGA TGGTGAGCGCAACAGTGATGCCTTTCCTAGCCCCCTGCTCCCTCCCCATGCTAAGGCCGG TTCCCTGCTCACATTCCCTTCCTTCCCACAGCCCATGTTCCAGAGGCGAAGGAGGCGAGA CACCCACTTCCCCATCTGCATTTTCTGCTGCGGCTGCTGTCATCGATCAAAGTGTGGGAT GTGCTGCAAGACGTAGAACCTACCTGCCCTGCCCCCGTCCCCTCCCTTCCTTATTTATTC CTGCTGCCCCAGAACATAGGTCTTGGAATAAAATGGCTGGTTCTTTTGTTTTCCAAA OMIM ID 606464