Entrez gene ID | | 5782 |
Official gene symbol | | PTPN12 |
Full name | | protein tyrosine phosphatase, non-receptor type 12 |
Aliases | | ,PTP-PEST,PTPG1, |
Gene summary | | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq] |
Location | | Chromosome: 7 Locus: 7q11.23 |
Gene position | | 77166773 - 77269388 Map Viewer |
Gene orientation | | plus |
Gene size | | 102616 bp |
Gene sequence |
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OMIM ID | | 600079 |
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