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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PTPN12 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5782
Official gene symbolPTPN12
Full nameprotein tyrosine phosphatase, non-receptor type 12
Aliases,PTP-PEST,PTPG1,
Gene summaryThe protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq]
LocationChromosome: 7   Locus: 7q11.23
Gene position77166773 - 77269388  Map Viewer
Gene orientationplus
Gene size102616 bp
Gene sequence
OMIM ID600079