Entrez gene ID | | 58160 |
Official gene symbol | | NFE4 |
Full name | | transcription factor NF-E4 |
Aliases | | ,NF-E4, |
Gene summary | | The erythroid-specific protein encoded by this gene, and the ubiquitous transcription factor CP2, form the stage selector protein (SSP) complex, which is involved in preferential expression of the gamma-globin genes in fetal erythroid cells. Alternate use of an in-frame upstream non-AUG (CUG) translation initiation codon, and a downstream AUG codon, results in two isoforms. While the long isoform (22 kDa) acts as an activator, the short isoform (14 kDa) has been shown to repress gamma-globin gene expression. This gene is located in an intron of the FBXL13 gene on the opposite strand. [provided by RefSeq] |
Location | | Chromosome: 7 Locus: 7q22.1 |
Gene position | | 102613884 - 102619114 Map Viewer |
Gene orientation | | plus |
Gene size | | 5231 bp |
Gene sequence |
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OMIM ID | | 612133 |
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