Entrez gene ID | | 5817 |
Official gene symbol | | PVR |
Full name | | poliovirus receptor |
Aliases | | ,CD155,FLJ25946,HVED,NECL5,Necl-5,PVS,TAGE4, |
Gene summary | | The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
Location | | Chromosome: 19 Locus: 19q13.2 |
Gene position | | 45147098 - 45169429 Map Viewer |
Gene orientation | | plus |
Gene size | | 22332 bp |
Gene sequence |
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OMIM ID | | 173850 |
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