Entrez gene ID | | 5871 |
Official gene symbol | | MAP4K2 |
Full name | | mitogen-activated protein kinase kinase kinase kinase 2 |
Aliases | | ,BL44,GCK,RAB8IP, |
Gene summary | | The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. [provided by RefSeq] |
Location | | Chromosome: 11 Locus: 11q13 |
Gene position | | 64570713 - 64556609 Map Viewer |
Gene orientation | | minus |
Gene size | | 14105 bp |
Gene sequence |
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OMIM ID | | 603166 |
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