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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for RAG2 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 5897 Official gene symbol RAG2 Full name recombination activating gene 2 Aliases ,RAG-2, Gene summary This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms. [provided by RefSeq] Location Chromosome: 11   Locus: 11p13 Gene position 36619829 - 36613493  Map Viewer Gene orientation minus Gene size 6337 bp Gene sequence >RAG2:complement(36553493..36559829):Length=6337 ATTAGATCAGTGTTCATAAGAACATCTGTAGGCACACATACACACTCTCTTTACAGTCAG CCTTCTGCTTGCCACAGTCATAGTGGGCAGTCAGTGAATCTTCCCCAAGTGCTGACAATT AATACCTGGTTTAGCGGCAAAGATTCAGAGAGGCGTGAGCAGCCCCTCTGGCCTTCAGGT AGGTCTGATACCTTCATTTCTACCAAAGCTAAAAAATGGGAGCCTATGTTAGTAAACTTT AAGGGAATGAAGATGCCACATTTTGGCAGTGTGTTAGTCACAAGTGGATTTGGTGTCTAG ATAGGGAAGGGATGAGTAGAATTTGGAAAATGTGGGGCTTTCTGTTCTCTGGCTGCTTCA GGGATTTAATTATTAGGCCTTTAGAGCACTATTATTAATCTTCGTACATAAATCGTTCTC TGGCCTAAGACAGGAAGGAAGACCTAATCCTGGTTTTACTGCCAGCAGAAATAAAATAAT ATATGCCTCAAACCTGATTAACAGTGCAAGATACTGTTATTCACACATTAAATGCCTGAA GTTACTTACATGAGGTTACTTGCTACTCTGGAGCAATCAAGAAAACATGGCCAGCACGGA TCAGCAAGATTTAATGTTTCACAGTACAGTATCTTTCTTTGGAAAAGAAAAAGTCAGTTC AGATATTAGGAACTATAAACCCAGACCTCATACTATGAGTCCTTTCATTATACTCAACTA TGCCCTAGCATCAGAGAGAATAAATGAAAATCTCCCTGCTGAAGAATGTTAGCATGGGGT TGGGAAAATTGTATATATTTATTGGTCCTATATTTCTGTCCTTTACAAAGAATCTTTAAT GTGTTGACCTTGAAGCCTCCCTCAGCTGAAGAACAGGATCTTATTCTTTTAAATCTGCCT GTTTTTATGTAGCCTATTAAAAGGAAAAGACTTCAGTAGGTTATTTTAGATATAGTATAA TCATTTAAAAACTCTTTTTAAAAACCAAGGTGTGACTAATACAGTCATATTGAAACTATG GAAGAGATACAATGGTCTACTCCAGTGAAAAATATATTCAAGTTGATAAAGCAAAATTTC AAAAACCAAATGTGGCAAAATCATGTGAAAACACTTTCAATGTTCCTGTTTATTCTTTAA ATGCATACATCATCTGGTTAAAGTGAGTAATCTAAAAATTAATTACTCACACTTGAACCA TGTTACAAGAGGAGGTAATTCATCTTAGCAATAAGAAACTTTACCACTGTTTTTAGGGCC TTGAAATTATGAAATGAGCCAAAAGCAGAGCATCAAAGGGAAAACAGGTCAAAAGCCCTG TTTCAAAAATCTTTAGGGGCCTAGACTAAGCTACAAAAATGGACAATCCTCCTTATGTCT TGCCCAAGAAAATGTTTCTGTGTAATCTACAATAATCATGTTTTCACTTACGAGAAGCCA CAATTCCTACAGCAACCTTAAAATGAAACCAAGAGGCGACAATAAAAACATTGCTTTAAA ACAACTGTTCTTGAAAAATCCCTTTGGATCTGGAATCCATTACCACTGTATGGCTTGCCT TGTATCTCAATAACAGTCATCACAGGTGTTTGAAACAAGCAGGCCTTGGCTTTGGTGTTC CCCCCACCCAAAATGGGACAACTCTCTGATCATAATCACTCAGGCTGAGTGTAATCACCT ACAGTTTTCTGAAGTGAGGGTCAATAATGTCTCCTTTTAGTTTCTATGAATAGCATTTTT CATAGTTGCTCAGATGCCTTCCCTCATGTAGGCTTGGGTAGGCCATGATATAAATAAAAC ACTGCCTAGATTATTTTATAAGCAGGGCAGTTTGCTGAATATACAACTGAGGGAGACAGG CTTGTTTTCATAACTTTGATAATAATCCTTCTGAGACACCATTTCCTCACCTGCTTTAAT AACCCACCAGATAATTGTTGAAAGATCACCCCCTTACGAGTCTCCCAAGTAGACTGAAAA TAATAACTACAAGAGATTATTTAGCAGTAAATTACAGCTGATCTACAGAAGTTCTTTAAA GCAAAAAAAAAAAAAAACAAAAAAAAAACACTACCATCTCATTAGAGTGACCAGAGATTC TAAATAGTCCAAGGAATCTTTGCAGGAGGAATAAAGATAAATTAGATAAATTATAGTATC AATTAACATTTATTGAGTGTTTATGTGCCAGGCACTGTTCTATGTGATTTACACGTGCTA TCCCATTTATTTCTCAAAACAGCCCAGTGAATATATACCAAGATTATCCCCAGTTAGACA AAGGGTGACAAGAAGAATAAAATATTAACTATCTTCTGTTAATAAATTAACTACTACCAG CACCCTCATCATATATGTTTATCCAATTCTTTTAGTTCAAATGTTTATCTGTCTATACCC ACTGACCTGATTCCCATATCCTAAAGCCCCTTCTCATCCTCTCCAACCTTATCAACTGCC ATTACTGGCAGGTGCGTATGCACTAGACCTTATTTTTGGTAAATTTTAAAATAATCATAA CTATCGTCTACTATATGCAAATCCCTGTTCTAAGTACTTTACGTATATTCAACTATTAAT CATAACTGACATCAATATATGAGGTTGGTAAAATTATTATCTCAGTTTTCAGATGAGGAA ACTGAGGCACACAGAGGTTACATAACTTGCCCAAAGTCATGTAGTTAGTGGCAGAGCCAG GATTTGAATCCAGCCAGTAAGCATTCAGAGTCCACACTCAGCCATTGTTTATACTGCTTT TGAAGCATATTAAGAATTAACTCTTAAAAGTCAAGAAATCTGTGCTATGTTTTGTTTCCT TTAACATTTGGTGCACAGGACATCACACTGCAAACACGGAGTGTATTCCACAACTCTCTA AGGTAAACAATAATAAAATAGAAATTTATCAAGCTTCCTTCATCTAGTAAATATTCTTTT TGTTGTAACACAAGTATGAAATTCTGAATAATTCAAACACTTCTATGCTTAGTCCCTGCT TACTTACTACAGAATTATTAAAGAATTACCCAAAAGTTCTTGGACTGGAAAGATGTGAAA AAGCCACTAACTCTATTTTCCTAGAATGAAGATGAAAAGAAGATGTGTTTAGGAACCTTC TCTGCTTCCCTAAAAGAACCCTAAAAACAGGAGTAAAAACAGTGAAGAAAACAAAGGACC TTCAAAGTGCACTCGTTAAAACCTAATAACTGTATTTCTATTACTAAATGTAGAAGTGGT AAACATCTTTAACAGGCAATGTCTCCCCTGCACTCTAGGGATTCAAAGATCCATCTTTCG GTTCTGTAAGACAGTCACGGCTTTTGTAACCTCGGTGCCCCCTTCAACCTCCCGCCCCAA GCACCTCCAGGGTCGTCAGGGGTGTAGTTTTGAGTCGCGCTCCTAAGCATCCAGACAGGC AGGACACCGTAACGACATCTCTGCCGGGAGTCCCTTCAGACTGCGGTCTCCAGGTAACCG CACTCCAACAGAAGCAGTTGTGCTTCCTATCGGGTCACCTGTTCAAAAGTCCCCAGGAGA GGCTCCAGCAATACCAGGGTAGCGGTTTGCCCGACACCGCTCCGGGCGCTGCAGCCTTCC GGCAACCCGGACGTTGGGTCGGTGTCAGCCACTCTCACCTCCCATTCCCTAGTTTTCCTC CTTTGCTCCCGTCTAGTCACTTCGCACCTTCGGCTAGTCTTTATTCACAGACACATTCCA GGAGTCCCCTCTCCCAGAGCAACAAAGACAGATTTCCAAAGCTACACATCCCAGAGAGAA CGGATTCTTGGGAAATGTGGTTCTTTCAGCTGACGCATGGTGACTCTTTACGGAAAAGGA CTACAATTCCCAGAAATCCTAGGGAGCATATAGTCCGTGGCTAAAACATGTCCCAGCTCC TTGGATGGAATGGCAGTAAAGGTTCTGTGGCTCTTTACTGACCTAACTCCTTGGATTTTC CTCATTCAGTCCCACTGCAAGCGTGTGGGAGGACTTAAAAAAATGCTATTCACATGTGAA GGAATCTAAATACGATGATTATATGAAGCGATCTCTAAGTCATTTTATTTTATAATTCTT TCAGACAAAAATCTACGTACCATCAGAAACTATGTCTCTGCAGATGGTAACAGTCAGTAA TAACATAGCCTTAATTCAGCCAGGCTTCTCACTGATGAATTTTGATGGACAAGTTTTCTT CTTTGGACAAAAAGGCTGGCCCAAAAGATCCTGCCCCACTGGAGTTTTCCATCTGGATGT AAAGCATAACCATGTCAAACTGAAGCCTACAATTTTCTCTAAGGATTCCTGCTACCTCCC TCCTCTTCGCTACCCAGCCACTTGCACATTCAAAGGCAGCTTGGAGTCTGAAAAGCATCA ATACATCATCCATGGAGGGAAAACACCAAACAATGAGGTTTCAGATAAGATTTATGTCAT GTCTATTGTTTGCAAGAACAACAAAAAGGTTACTTTTCGCTGCACAGAGAAAGACTTGGT AGGAGATGTTCCTGAAGCCAGATATGGTCATTCCATTAATGTGGTGTACAGCCGAGGGAA AAGTATGGGTGTTCTCTTTGGAGGACGCTCATACATGCCTTCTACCCACAGAACCACAGA AAAATGGAATAGTGTAGCTGACTGCCTGCCCTGTGTTTTCCTGGTGGATTTTGAATTTGG GTGTGCTACATCATACATTCTTCCAGAACTTCAGGATGGGCTATCTTTTCATGTCTCTAT TGCCAAAAATGACACCATCTATATTTTAGGAGGACATTCACTTGCCAATAATATCCGGCC TGCCAACCTGTACAGAATAAGGGTTGATCTTCCCCTGGGTAGCCCAGCTGTGAATTGCAC AGTCTTGCCAGGAGGAATCTCTGTCTCCAGTGCAATCCTGACTCAAACTAACAATGATGA ATTTGTTATTGTTGGTGGCTATCAGCTTGAAAATCAAAAAAGAATGATCTGCAACATCAT CTCTTTAGAGGACAACAAGATAGAAATTCGTGAGATGGAGACCCCAGATTGGACCCCAGA CATTAAGCACAGCAAGATATGGTTTGGAAGCAACATGGGAAATGGAACTGTTTTTCTTGG CATACCAGGAGACAATAAACAAGTTGTTTCAGAAGGATTCTATTTCTATATGTTGAAATG TGCTGAAGATGATACTAATGAAGAGCAGACAACATTCACAAACAGTCAAACATCAACAGA AGATCCAGGGGATTCCACTCCCTTTGAAGACTCTGAAGAATTTTGTTTCAGTGCAGAAGC AAATAGTTTTGATGGTGATGATGAATTTGACACCTATAATGAAGATGATGAAGAAGATGA GTCTGAGACAGGCTACTGGATTACATGCTGCCCTACTTGTGATGTGGATATCAACACTTG GGTACCATTCTATTCAACTGAGCTCAACAAACCCGCCATGATCTACTGCTCTCATGGGGA TGGGCACTGGGTCCATGCTCAGTGCATGGATCTGGCAGAACGCACACTCATCCATCTGTC AGCAGGAAGCAACAAGTATTACTGCAATGAGCATGTGGAGATAGCAAGAGCTCTACACAC TCCCCAAAGAGTCCTACCCTTAAAAAAGCCTCCAATGAAATCCCTCCGTAAAAAAGGTTC TGGAAAAATCTTGACTCCTGCCAAGAAATCCTTTCTTAGAAGGTTGTTTGATTAGTTTTG CAAAAGCCTTTCAGATTCAGGTGTATGGAATTTTTGAATCTATTTTTAAAATCATAACAT TGATTTTAAAAATACATTTTTGTTTATTTAAAATGCCTATGTTTTCTTTTAGTTACATGA ATTAAGGGCCAGAAAAAAGTGTTTATAATGCAATGATAAATAAAGTCATTCTAGACCCTA TACATTTTGAAAATATTTTACCCAAATACTCAATTTACTAATTTATTCTTCACTGAGGAT TTCTGATCTGATTTTTTATTCAACAAACCTTAAACACCCAGAAGCAGTAATAATCATCGA GGTATGTTTATATTTATTATATAAGTCTTGGTAACAAATAACCTATAAAGTGTTTATGAC AAATTTAGCCAATAAAGAAATTAACACCCAAAAGAATTAAATTGATTATTTTGTGCAACA TAACAATTCGGCAGTTGGCCAAAACTTAAAAGCAAGATCTACTACATCCCACATTAGTGT TCTTTATATACCTTCAAGCAACCCTTTGGATTATGCCCATGAACAAGTTAGTTTCTCATA GCTTTACAGATGTAGATATAAATATAAATATATGTATACATATAGATAGATAATGTTCTC CACTGACACAAAAGAAGAAATAAATAATCTACATCAA OMIM ID 179616