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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for RASGRF1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5923
Official gene symbolRASGRF1
Full nameRas protein-specific guanine nucleotide-releasing factor 1
Aliases,CDC25,CDC25L,GNRP,GRF1,GRF55,H-GRF55,PP13187,
Gene summaryThe protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]
LocationChromosome: 15   Locus: 15q24.2
Gene position79383215 - 79252289  Map Viewer
Gene orientationminus
Gene size130927 bp
Gene sequence
OMIM ID606600