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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for ALOXE3 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID59344
Official gene symbolALOXE3
Full namearachidonate lipoxygenase 3
Aliases,E-LOX,MGC119694,MGC119695,MGC119696,eLOX3,
Gene summaryThis gene is a member of the lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha), which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in ichthyosis, implicating the function of this gene in the differentiation of human skin. This gene is part of a cluster of lipoxygenase genes on 17p13.1. Mutations in this gene result in nonbullous congenital ichthyosiform erythroderma (NCIE). Multiple transcript variants encoding different isoforms have been found for this gene.
LocationChromosome: 17   Locus: 17p13.1
Gene position8022234 - 7999218  Map Viewer
Gene orientationminus
Gene size23017 bp
Gene sequence
OMIM ID607206