Entrez gene ID | | 5985 |
Official gene symbol | | RFC5 |
Full name | | replication factor C (activator 1) 5, 36.5kDa |
Aliases | | ,MGC1155,RFC36, |
Gene summary | | The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 36 kD subunit. This subunit can interact with the C-terminal region of PCNA. It forms a core complex with the 38 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq] |
Location | | Chromosome: 12 Locus: 12q24.23 |
Gene position | | 118454508 - 118470039 Map Viewer |
Gene orientation | | plus |
Gene size | | 15532 bp |
Gene sequence |
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OMIM ID | | 600407 |
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