Entrez gene ID | | 604 |
Official gene symbol | | BCL6 |
Full name | | B-cell CLL/lymphoma 6 |
Aliases | | ,BCL5,BCL6A,LAZ3,ZBTB27,ZNF51, |
Gene summary | | The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq] |
Location | | Chromosome: 3 Locus: 3q27 |
Gene position | | 187463513 - 187439165 Map Viewer |
Gene orientation | | minus |
Gene size | | 24349 bp |
Gene sequence |
| |
OMIM ID | | 109565 |
|