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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for RNH1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID6050
Official gene symbolRNH1
Full nameribonuclease/angiogenin inhibitor 1
Aliases,MGC18200,MGC4569,MGC54054,RAI,RNH,
Gene summaryPlacental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM]
LocationChromosome: 11   Locus: 11p15.5
Gene position507273 - 494512  Map Viewer
Gene orientationminus
Gene size12762 bp
Gene sequence
OMIM ID173320