Entrez gene ID | | 6050 |
Official gene symbol | | RNH1 |
Full name | | ribonuclease/angiogenin inhibitor 1 |
Aliases | | ,MGC18200,MGC4569,MGC54054,RAI,RNH, |
Gene summary | | Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM] |
Location | | Chromosome: 11 Locus: 11p15.5 |
Gene position | | 507273 - 494512 Map Viewer |
Gene orientation | | minus |
Gene size | | 12762 bp |
Gene sequence |
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OMIM ID | | 173320 |
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