| Entrez gene ID | | 6093 |
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| Official gene symbol | | ROCK1 |
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| Full name | | Rho-associated, coiled-coil containing protein kinase 1 |
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| Aliases | | ,MGC131603,MGC43611,P160ROCK,PRO0435, |
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| Gene summary | | This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. [provided by RefSeq] |
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| Location | | Chromosome: 18 Locus: 18q11.1 |
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| Gene position | | 18691812 - 18529701 Map Viewer |
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| Gene orientation | | minus |
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| Gene size | | 162112 bp |
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| Gene sequence |
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| OMIM ID | | 601702 |
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