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Gene information for RPL22 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID6146
Official gene symbolRPL22
Full nameribosomal protein L22
Aliases,EAP,HBP15,HBP15/L22,
Gene summaryRibosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22E family of ribosomal proteins. Its initiating methionine residue is post-translationally removed. The protein can bind specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse protein has been shown to be capable of binding to heparin. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. It was previously thought that this gene mapped to 3q26 and that it was fused to the acute myeloid leukemia 1 (AML1) gene located at 21q22 in some therapy-related myelodysplastic syndrome patients with 3;21 translocations; however, these fusions actually involve a ribosomal protein L22 pseudogene located at 3q26, and this gene actually maps to 1p36.3-p36.2. [provided by RefSeq]
LocationChromosome: 1   Locus: 1p36.3-p36.2
Gene position6259679 - 6245080  Map Viewer
Gene orientationminus
Gene size14600 bp
Gene sequence
OMIM ID180474