Entrez gene ID | | 6240 |
Official gene symbol | | RRM1 |
Full name | | ribonucleotide reductase M1 |
Aliases | | ,R1,RIR1,RR1, |
Gene summary | | This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. [provided by RefSeq] |
Location | | Chromosome: 11 Locus: 11p15.5 |
Gene position | | 4115924 - 4160106 Map Viewer |
Gene orientation | | plus |
Gene size | | 44183 bp |
Gene sequence |
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OMIM ID | | 180410 |
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