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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for SAFB (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID6294
Official gene symbolSAFB
Full namescaffold attachment factor B
Aliases,DKFZp779C1727,HAP,HET,SAF-B1,SAFB1,
Gene summaryThis gene encodes a DNA-binding protein that has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. This encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of the heat shock protein 27 transcription and also can act as an estrogen receptor corepressor. This gene is a candidate gene for breast tumorigenesis. [provided by RefSeq]
LocationChromosome: 19   Locus: 19p13.3-p13.2
Gene position5623164 - 5668489  Map Viewer
Gene orientationplus
Gene size45326 bp
Gene sequence
OMIM ID602895