Entrez gene ID | | 63941 |
Official gene symbol | | NECAB3 |
Full name | | N-terminal EF-hand calcium binding protein 3 |
Aliases | | ,APBA2BP,EFCBP3,NIP1,STIP3,SYTIP2,XB51,dJ63M2.4,dJ63M2.5, |
Gene summary | | The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
Location | | Chromosome: 20 Locus: 20q11.22 |
Gene position | | 32262264 - 32244893 Map Viewer |
Gene orientation | | minus |
Gene size | | 17372 bp |
Gene sequence |
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OMIM ID | | 612478 |
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