Entrez gene ID | | 6416 |
Official gene symbol | | MAP2K4 |
Full name | | mitogen-activated protein kinase kinase 4 |
Aliases | | ,JNKK,JNKK1,MAPKK4,MEK4,MKK4,PRKMK4,SEK1,SERK1, |
Gene summary | | This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver. [provided by RefSeq] |
Location | | Chromosome: 17 Locus: 17p11.2 |
Gene position | | 11924135 - 12047051 Map Viewer |
Gene orientation | | plus |
Gene size | | 122917 bp |
Gene sequence |
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OMIM ID | | 601335 |
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