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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for MAP2K4 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID6416
Official gene symbolMAP2K4
Full namemitogen-activated protein kinase kinase 4
Aliases,JNKK,JNKK1,MAPKK4,MEK4,MKK4,PRKMK4,SEK1,SERK1,
Gene summaryThis gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver. [provided by RefSeq]
LocationChromosome: 17   Locus: 17p11.2
Gene position11924135 - 12047051  Map Viewer
Gene orientationplus
Gene size122917 bp
Gene sequence
OMIM ID601335