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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for LEPRE1 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 64175 Official gene symbol LEPRE1 Full name leucine proline-enriched proteoglycan (leprecan) 1 Aliases ,GROS1,MGC117314,OI8,P3H1, Gene summary This gene encodes an enzyme that is a member of the collagen prolyl hydroxylase family. These enzymes are localized to the endoplasmic reticulum and their activity is required for proper collagen synthesis and assembly. Mutations in this gene are associated with osteogenesis imperfecta type VIII. Two alternatively spliced transcript variants encoding different isoforms have been described. Other variants may exist, but their biological validity has not been determined. [provided by RefSeq] Location Chromosome: 1   Locus: 1p34.1 Gene position 43232755 - 43212006  Map Viewer Gene orientation minus Gene size 20750 bp Gene sequence >LEPRE1:complement(13183924..13204673):Length=20750 ATGCGCCGCCCGGCTTGGAAGGTGGGGCTTCGCCCGGGGGCGGGCCTTCGCCGGGGGTAG GACTCCGGCCTTGGTGGCGGGTGGCTGGCGGTTCCGTTAGGTCTGAGGGAGCGATGGCGG TACGCGCGTTGAAGCTGCTGACCACACTGCTGGCTGTCGTGGCCGCTGCCTCCCAAGCCG AGGTCGAGTCCGAGGCAGGATGGGGCATGGTGACGCCTGATCTGCTCTTCGCCGAGGGGA CCGCAGCCTACGCGCGCGGGGACTGGCCCGGGGTGGTCCTGAGCATGGAACGGGCGCTGC GCTCCCGGGCAGCCCTCCGCGCCCTTCGCCTGCGCTGCCGCACCCAGTGTGCCGCCGACT TCCCGTGGGAGCTGGACCCCGACTGGTCCCCCAGCCCGGCCCAGGCCTCGGGCGCCGCCG CCCTGCGCGACCTGAGCTTCTTCGGGGGCCTTCTGCGTCGCGCTGCCTGCCTGCGCCGCT GCCTCGGGCCGCCGGCCGCCCACTCGCTCAGCGAAGAGATGGAGCTGGAGTTCCGCAAGC GGAGCCCCTACAACTACCTGCAGGTCGCCTACTTCAAGGTGCAGACCTGCCTGGAACCAG GCGGCCGGGGTCCTTCTGGGGAGAGGAGTGTTGCAGGGGACCTGAGGAGCTTGGGGGATC GGGGAAGTGTCCGCAGGGAGGGGAAAGTGGCCTCCTGGCTGGGGAGCTCTCCTCGGAGCC GGGGAGAGCTGCTCCCTGGCAGGAGACCTTCCTCGCCCAGTTCGCATGGGCAGATGCTAA CCCCAAAGGTCCAGCCTGGGGTTAGGGCACAGGCCAAGCAAAACTCATGGCCATTTTGTT CCCTGGGAAATCTCCTGGAAGGAATTAAAGCGGCAGTTTGGGTCTCCCATTCTGATGTCA TTGTAAGTGTCCGAGTGAGAAGCTAGTAGCGGTCTACAATATCTCCCTTCCGGTTGGTTT TCCAGTGGTGCTTTTCCTGCTGTTTGATTCAGCAGCTCTCTTTCAGGATGTGAGGTTGCC ACGTCGCCAGCAGGGGCTGCCTGGCCCTTTCTGTGTGTGTGTGGGGGCGGGGGGGGGACC CTCTGGCTAGTCTGCCAGGTTTACAAAGAAAATGAGTATTTTTCGGAATGCCAGAGTGCC ATGTGTCCAAGTGTACACTTGGGCTTGGAGCGTTCCAGGCTTGTTTGGTGGTGGTGATGG TGACGATGATGATGATGATGATAGCCAGCACATACTTCCAGGCACTATTTTAAGCAGTTT GCATTTATTAACGCATTTGCCCTAATCTTCATAATATCTTGTCAGGTAGATGCTGTTATT AGTCCCACTGTATTGGGGGTGGGGGGAGAAAGAGTTGTGCATTATATCTGGTATATCTGT TGTTTAAAAGACCTTCGATTCGATCTAAAGAGACACTTAGAGACTCTTGGGGACCTCAGA TTTCCACCCCTCCACAGCATTCTGCCTACACAGTTCCCCTCATTTTTCCTAGTTACTCGG AAGAGCGCTGGACTTGAAATCAAAATAATTGCGTTATGTCTTTGGTTATGTCGCTTCATC ATAGCACTTTCTAAAACTATTTGACAAACATGTATTGCATACCTACTGCATTCCAGTTCT TGTACAAGTAATTAAATGCTCGACTAACGTCTTTGCTTTGTCTTGCTTTGCTGTTAAGAG TTACTGTAGTAAGGGCTACTGCAAGGGCATATACTTAGGGCTGCGGGAGCACAAAGGAGG GAGACTCTAGCTTTATCTCAGAGAAATTAGACTTCAAAGAAGAGGTAATATTGAAGCCTG CCCTAAGTATTGCCAGGGGGAGAGGAAAGAAGGCTCCTCCAGATAGAGAGAAAAGTAGAA CCAAAGCATGATGTATTCAGGAAAAAAAATGAACTCTTGTGATTGCAATGTCGAGATGTG TGTGGGGAGTAGTAGGAGAGGCGGCTAGAAAAGTCAGTGAGGCCAGATTTGGAAGAGAAT TCTGCGGACTGCAGGGAGCCATCCTCAGATTTGGGTTTTAAAACGCTTATTCTGGAAGCC ATGGTGAATGAGCCTTGGAAGAAGGAGAAAGTGGTGGCACTTGATTAGGAGGCAGACATT TGTCCACAAGAGAGGAGGTTAAGTACCTCAGTGCTTAGAGAGTAAAGAAGGCTGGGGGTG GAGAGAGGAGTGAGGACATGAGGGAGAACAGAGAAAGGCAGGAGCAGCGCTGAAAGACAC AAGAGCTAGAGTAATTCCATGAAAGGGACAGACCTGAAAAAATTTCTAATTTTACAGTTA AAGAAACTGAGGTACAGAGATGGGGAGTTATTTACCTTGGGTCACCTAACCAGGGCTGAC TCCTTTAGTGTGCCTTTACTAGTACCAATGATAAGAAAATAAGTTTTCTTAGCATATTAA TCATACCACCTAAAATTTATTGAGCACTTAATCTGTGCCCAGCACCATGTATTACAGGCT GCATATTATCTCGTTGAACTCTCAACAATGCTAGGAGATAGCTAGAGAATGCTATCTCCA GATGATAGATTAGGGAAACTGAGTTTAGAAAGTAAACTTTAAGTATCTTGTCTACTGCCC AGCCAGTCAGTGAGTCATTAAGCCCAGATGTGATGCTGGCCTGTCTCTTTTCTTTCTTTC TTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTCGCTGTTGCCAGGCTGGAGTGCAGTGG CGACCTTGGCTTACTGCAACCTCTGACTTCTGGTTTTCTGGTTCAAGTGACTCCCCTACC TCAGCCTCCCGAGTAGCTGGGATTACAGGCACGTGCCATCACATCCGGCTAATTTTTGTA TTTTTAGTAGAGATGGGGTTTCTCCATATTGGCCAGGATGGTCTGGATCTCCTGACCTTG TGATCCACCTGCCTCGGCCTCCCAAAGTGCGGGATTACAGGCGTGAGCCACCGCACCCAG CCCTCTTTTCTTTTGAGACGGAGTTTCGCTCTTGTTGCCCAAGCTAGAGTGCAATGGTGC GATCTCGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTC CTGAGTAGCTGGGATTACAGGCACATGCCACCACGCCCAGCTATTGTTGGTCTCAAACTC CTGACCTCATGATCCGCTGGTCTCAAACTCCTGACCTCATGATCCGCCCGCCTCAGCCTC CCAAAGTGCTGGGATTATAGGCGTGAACCCCCGTGCCTGGCCACGGCTGGTCTCTTTGAT ACCAGTGTCCACATAGTTAATTACTAGATCATCAGTGATTTATTTGGTTGGATTCTATAT ATGAAACCTGTGTTACTTTGACATGCTGGAGTCCATTGCTGTGGGCATTGTGGTCTGTAG CCTATTTCTCCCCCCTTGGATTTCTTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACAAG AGTCTCGCTCTGTCACCCAGGCTGGAGTATGGTGCTGTGATCTCGGCTCGCTGTAACCTC CGCCTCCCGGGTTCAAGCGATTCTCCTGCTTCAGCCTCCCAAGAAGCTGGGATTACGGGT GTGCGCCACAACGCCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTT GGCCAGGCTGGTCTCAAACTCCTGACCTCAAGAGATCTGCCCCCTTCGGCCTCCCAAAGT GCTGGGATTACAGGCATGAGCTACCGCCCCCGACCACCCCCTCAGATTTCTTAGAGCTAT TTGTTTGAACCTCATGAGCCCTGAGCTTTGAGTCAGAAAATACTATGTCTGGACTTAGTA AAGGACCTTAGAATTTTTAGCCATCCACCTTTTCCCTAAATGTCTCAAAAATTCTTCATT TTATTTTATGCAAAAAAAAATTTTTTTCTAGGAAAATTCTTAGGCATAGTCTGTTAGCTG CTCTTTTTTCTCTACCCCTAAATCCTTGAAGCCACAGAATTTCTTCAGCTCAGGCATTAC ATTTGATTCATGAAATATATATATGTATTTTTTTTTTTTTGAGTCAGGGTCCTGCTGTGT CACCCAAGCTGGAGTGCTGTGGCACCATCTTGGCTCACTGCAACCTCTGCTTCCCAGGCC CAAGCGTCCTCCCACCTCAGCCTGCAGAGTAGCTGGGACTACAGGCATATAGTACCATGT AATTTTTGTATTTTTCGTAAAGACAGGGTTTCACCATGTTGCCCAGACTGGTCTTGAACT CCTGAGCTCAAGTGATCCACCTGCCTCGGCCTCTAAAAATGCTGGGATTACAGACCTGAG CCACCGCACCCAGCATGAAAACATATTATGTGGGCAGTCAGTCTTTCACAGCACTCCCCA TACAATATGACCTTTGTTTTAAAATGGAACATTGCTACTTCCTGTAATCTGGGGAACCCC TAAATCTGACTTGGGAAAGAGCTACAAATCTGCCCAGGGCACTATGCTCCTAATCTGTCG TGGGTAGTTCCTGCAATAGGTGTGCTTCCTGGGGCTGGCAGGGGCTGGGCACGCTGAGTG GAGGGCTCAGGGAGGCAGGGATTTCCTGTTTATGTGGACTGCTCATGTGGACACAAACGT TCAGAGATTGGATGTGAGCATTATCCACCTTCTCATGCTTCATTCTTAGATCAACAAGTT GGAGAAAGCTGTTGCTGCAGCACACACCTTCTTCGTGGGCAATCCTGAGCACATGGAAAT GCAGCAGAACCTAGACTATTACCAAACCATGTCTGGAGTGAAGGAGGCCGACTTCAAGGA TCTTGAGACTCAACCCCATATGGTGAAAAAAACTTTATCCCCTTCTTTCTTTCTTTCTTT TTAAATTTATTTTAGAGACAGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCTTG ATCATAGCTCACTGTAACCTCAAATTCCCGGACTCAAGAGACCCTCTAGTCTCGGCCTCC TGAGTAGTTGGGACTACAGGCATGCATTCTTTTGTTTTTTTTTAAATGACATTACTAAGG TTGTTTTCTAATTACATTACAGAAGTAATGAATGTTCATTGTATAACATTGTAGAAATGT AGGTAAGTATAAAATAAAAAGTAATCATTTGTAATACCGCCACCTTAAGAAAACCAGTTT ATATTTTGCCCTATTTTTTAAGTCTTCCGTATATAATTTTTTCATCTAATTTGGTGTTAT ATCATGTATGCATTTTTTATCATCTTTTTTATTTTTTTTGAGGCAGGGTCTCACTTTGTT GTCCAGGCTGCAGTGCAATGGTGTGATCATAGCTCACTGCAGCCTTGACCTCCTGGGCTC AAGTGATCCTCCCGCCTCAGCCCCACAAATAGCTGGGACTAGAGGCATGCACCACCATAC CCAGCTATTGTTTTTATTTTTTGTAGAGACGGGGTCTCACTGTGTTGCCCAGGCTGATTT CAAACTCCTGGCCTCAAGCGATCCTACTGCCTTGGGCTCCCAAAGTGCTGGGATTGCAGG TGTGAGCCACCATGGCCAGCCCCATCATCATTTTTTAACTAACATTATTATCATGAGTCT TTTCTCATGTCTTCAGTTTTATTTGAAAACATAATTGTTTATGGCTGCATGATAGTCCAT CTTATGCAGAGACTATATTAATTCACTAGTCACATTTTTTTGGTCATGTATGTTTTTGAT TTTCACTACAATAAATGTTACAGTATCCTTCAATGTTCTCATTCTATTTGTTTAGCAGGA AAAGTTCCAAAGGAGGGACTGTCTGTGATGATATAGCATTTTATAGAGAGTTTATGGTTC CTTACATTTTAATTATAAAATAGGAATGTTAGAAACAATATAAGAATGACTTATAGGCCA GGCGCAGTGGCTAACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACT TAAGGTCAGGAGTTTGAGACCAGCCTGGCCAATATGGTGAAACCCCATCTCTACTAAAAA TACAAAAATTAGCCAGGCATGGTGGCATGCACCCGTAATCCCAGCTACTCGACATGGAGG CAGGAGAATAGCTTGAACCTGGAAGGTGGAGGTTGCAGTGAGCCAAGATTGTGCCACTGC ACTCCAGCCTGGGTGACAGAGCAACAGTCAAAAAAAAAAAAAAAAAAAGAATGACTTTTA AAAGTAAGTTGTGGCCAGGTGCAGTGGGTCACACCTGTCATCCCAGCACTTTGGAAGGCC AAGGCGGGCGGATCACAAGGTCAGGAGATTGAGACCGTCCTGCCTAACATGGTGAATCCC TGTCTCTACTAAAAATACAAAAATTAGCTGAGCGTGGTGGTGTGTGCCTGTATTCCCAGC TACTCAGGAGCCTGAGGCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAGC CGAGATTGTGCCACTGCACTCCAGCCTGGGTGACAGAGCGAGACTCCATCACACACACAA AAAAAAGTAAGTTGTGTTGGCCGGGCGTGGTGGCTCATGCCTGTAATCCCAGAATTTTGG GAGGCCGAGGTGAGTGGATCACTTGAGGCCAGAAGTTCAAGACCAGCCTGGCCAACATGG TGAAATCCTGTCTCTACTAAAAATACAAAAATTAACCAGGTGTGGTGGTGTATGTCTGTA ATCCCAGCTTCTCAGGAGGCTGAGGCGCTAGAATCACTTGAACCCAGGAGGTGGAGGTTA CAGTGAGCTGAGATCATGCCACTGCCCTCCAGCCTGGGCTGTCTGTCTCAAAAAAAAACT CTGTCTCAAAACAAAACAAAACAAAAAGTAAGTTGTGTTTATTTGAAAACTGTTAGCCCT ACAAAAAAGTGCAAGAACCTAGGCCAGGCACGGTGGCTCATGCCTGTAATCCCAGCACTT CGGGAGGCCGAGGCGGGCAGATCACCTGAGGTCAGCAGTTCAAGACCAGCCAGACCAACA TGACAAAACCCCATCTCTACTAAAAACACAAAATTAGCCAGGCGTGGTGGCGCATACCTG TAATCCCAGCTACTCTGGAGGCTGAGGCAGGAGAATTGCTTGAACCCTGGAGGCGGATGT TGCAGTGAGCCAAGATCGCACTATTGCACTCTAGCCTGGGCAACAAGAGTGAAACTCCGA CTCAAAAAAAAAAAAAAAAAAAAGTGCAAGAATCTGTCACTAATGGGGGGGGAAGAAAAG TACAAGAAAATCATAATGAACTCCTAGATATCTTTCATCTAGATTAAGAGTTAAATGTTT TTTGGCCAGGCACAGTGGCTCACACCTGTAATCCCAGCACTTTAGGAGGCCGAGTTGGGA GGATTGCTTGAGGTTAGGAGTTGGAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTTT ACTAAAATACAAAAATTAGCTGGGCACAATGTAATCCCAGCTACTAGGGAGGCTGAGGCA AGAGAATCACTTGAACCCAGGAGGTGGAGGTTGCAGTGAGCTGAGATTGTGCCACTGCAG TCCAGCCTGGGCAACAGAGTGAGACTCTGTCTCAAAAAAAGAAAAAAAGAGCTAAATGTT TTTAAATTTCCAGAGCTAAATATTTTGTAAAGACCATTTACAAAAGGCCTTCATTTTATA GTGGTACCCAGGTCACCCCTTTCCATCCATAACCTGAGGAACAGGAAATTAGGACCCCTG TGAAGGTGGCTGAGGGCAAGGAGAGAGGGTTCCTCCTCTGTGGCCTGCATTTGAGTGCTC CTTCTTCCCAGTAGCAAGAATTTCGACTGGGAGTGCGACTCTACTCAGAGGAACAGCCAC AGGAAGCTGTGCCCCACCTAGAGGCGGCGCTGCAAGAATACTTTGTGGCCTATGAGGAGT GCCGTGCCCTCTGCGAAGGGCCCTATGACTACGATGGCTACAACTACCTTGAGTACAACG CTGACCTCTTCCAGGCCATCACAGGTGCGTGCAGTTCAGAGCCAGACCTTCAGCCAGGCC TCCTGGGACTCTAAGGTCACCATCTGATAATATAAATGGGGACTCTTCACCCTCATTCCT CAATTTATTAAATCTGAGAAGCTGATGAAAAATTGCTTCCATTTGAATTTGTTCATCTTA ACCAGAATTTGAGTTCTAAAGAGTGACCTCATAGTTATTCCTTCTGTTTGATTCCTTTCA GATCATTACATCCAGGTCCTCAACTGTAAGCAGAACTGTGTCACGGAGCTTGCTTCCCAC CCAAGTCGAGAGAAGCCCTTTGAAGACTTCCTCCCATCGCATTATAATTATCTGCAGTTT GCCTACTATAACAGTAAGGCCTACTTTCCTTCCTCTTTCTCTGCTGGCTAACTAAGAAGC TAAAGGCAAGGTGGGCAGGGATTACAGCCACTTACTTCCTCAAGGTGTTTGGCTTATTTC AGTAGCTATGGGAGGCACCATGCCAAGTGATCCCTGGGTAGTTTGTTATAAACAACTGGC CTAGGAAGCCAATACCAGCAACCCAAAAAGCTGGGGGAGGGAGACTTAGGACCTCATCTC TTGTCCCTTCTATAACTTGTAATCTATTTTTGCTTTTGAATTAAAGTTAATAGCAAAATA AGGGTATGCCACAGTTTAAACTAGCTCAGAGGACATTTGCTAGCCCTCTCCCTGGTATAG CACTGATGCTTTTGTGGGGCTGCCAATTAATACCCAGAAAACCAACTCTTTGCAGAGTCC CTACTGTGTGCTAAGCATTACAAACATATTGATGAGTGTACAATATTTACAGTTGAGTTG AGATGACTAACAAATATCAACAAGAACTATTTTGCCAAAGAGACAATCTGCTATTGTAAT CTTCCTTGTCTTCTGAAAATCTATAGAAAAAAGAAGGTAGGAAGACAGGGAAATTGATCT AATGATTGAGTGTATTGAGGCAAAATATTAAGGAGTATTGGAATTATTTGTGAATCTTAA AAGATGTGGGCATGCAGAGAATTCTGATTCTTTTCTGTTTCATTGTTAGGCAGCCCTGAG GACATTGACCACCTCACCTTAAAATTAATCACACATTCTATGTGTATTACTTAACTCCTG CCCCTGAAATCAGGCCATCATGTTAAGTAGCAGGCACCAGCTTGTCATGCTGCCATTGCC TCAAGCTTTGTGGAGACTGAACACTAAGTGGTCCCTGGTGCTAGGATTTTATCCTTTCCT TTTGACTCTTTCCTCTCAGCCATTCTTCTTTCCACTTTGCAGTTGGGAATTATACACAGG CTGTTGAATGTGCCAAGACCTATCTTCTCTTCTTCCCCAATGACGAGGTGATGAACCAAA ATTTGGCCTATTATGCAGCTATGCTTGGAGAAGAACACACCAGATCCATCGGCCCCCGTG AGGTGAGAGACTTCCTTCTGTTATGACAGCTGCCAGCTGAACTCAGACCTGAGGGCGGAA GAGTGGGGTAGCAGAGGGGAGTAGGCGCTGTGCGTGCAGGGCAGGGGCCAGATGTCAGTG TTGGGGCCAGATGTGAGTTCAGTCACTCGGCTTGTTATTCAGAGGAGAAGGGAGCACAGG GAGGGAGTGTGGGGAGTACACAGGAGCCTCAATTAGCGTTATCTGGGCCCAGAAGTCTAT TCTCTGAGTCCCGCAGAACTGCGCGGTGAGCATATTCTTTCCCCTCTTGGCACCCCTAAC TTGGACACTCGATATTATTTGGCCAAGAGCTATCATTTTTCACTTAATACTGGTTGTTTT TTTTCTGCTCACCTGTTTTCTGTCTCCATTTTCTTTCCCATCTCTTCTTCTTCCTGCCAT TGTTTGTTCTCTCCCATCTTTCAGCATTTTCCCTGTCTCTCTCCAAAACCAGGAGAAATA TCTGTATAACACAAAGACTGCTGCGCTGAAAGGAGACACCCAGGCTCTTCTTCCGAGCTC TGGAGTCTGAGAGCCTCCAGTAGAAACAGCCTCTTGCTGCCCCTCCTGTGTGGGTTGTCA TTGTAGTTGTCCTCTTTAGCCACTAGATGGTGACCATCTGGCTTTAAGATGGCACTTCCG GTCTCTTTTGTCTTGTTTGGTTAATACCTTTTCCCTGCCTTCCTTATGGCCATTAAGGGG AGTCTGAGGGGAGTGAGGGGAAATAAACCCACGTGGCCAATCTAGCATTTTTAACTAGAA GTCCCCTTTTGGAAAGAAGGCAACTAACATTTGTTGAGCCGCTGTCCAGGCGAAGCTCTG TGCGGGGTGGGCTGTATCCATCATCTCATTTAATCATCACAGCCACCCTGCAAGGTTGGC ACTCTTCTTCCCACTTTAGGGATGAGGACTGTTAGCATCTGAGAGATGAAGTAACTTGTG CAGTGGCTTGTGGCCAGTCAGTGGTGACCGGAATCTGTTCCCTGCTTGGACCCAGTGCAG GCACAGCTCCAGACACATGGCTGACACTCAGTAAATCAGCATCGAATGAATAAAGATGGA AGTGGGGTTTGCTTCATAGCAGCCTTATAGGGTCATTGGAGAGGGTTAAATGAGATAACA TAGCATTTGGTGACAGAAGCCAGTAATGTAAACTCCTGAAGAGAAAACGTCTCTCTTCCT CTTAGGTAAATATAGTAGATGACATAGGATTCATTGACTCCTTTAATTCCTCCTTGAACT GCCTCATGTTTTATTTCAACTGATGTCTCCTTTTTCTCTTCCTTCCTCCTCCTGCTGCTT GGAGATTAGCAGGGCACCTAGGGAAAGATGTGACCCCGGAAAGTACTCAGTTTCCCTGCC CTGGGTAAGCCTTGCCTGGGAGTCCATGTGGGAAGCCCAGAGTGCCAGGCCCTCCCCTTT AGCTGCTTATCCTCAGGGAGGGGTGTGGTCTGGTTAGGGTCTGAGAGGAGGCAGGTGGCA GAGCAGAAAGCACATGGGCTTTAGGACTGTAAAGACCCGGCTTTATCTGTCCAAATGCAC ATTCTGCTATGAAAAAAAAGAAAAAGATAACAGAAGACCTGGGTTTGACTGTAGGTCGCT GCTCTCCCATGTCCTGTAGTGTCACCTTAGACAGTGGTACATCTCCTCTGTGCCTCAGAT GCTTCCTCTGTAGAATGAGCATACTAGTATCAACCTCAGATGTGGCTATAAAAGATCAAA TGAATAACATGTCAGTTGCCTAATGCCTGATTCCTTTTCCTGCTTTGTGGACTCCTGTAG AAGTCAAGAAGGAATTCTCCTTCTTTGAAGAATATTTCCACTTTTGAGAATCATCAGATT ATCTGTCCTAGAGACTAATGGGGGTTGGGATGGGGGAGGAGCAGGGCTTTTTCCCTTAAG GAAAGCCTGGTTATTCCAGTACCTCAGAGGTACTGTTGCTTGTGCCAGGCAGAGGACACA GAAATTAGACTTTTGTCTCAAACTGGGGAACAGACAGAGAGCATTGGTAGGGAGAGGAGG CCTCAGGTCACATGGGAGCATCAGTGTGGGGTGCCAGGGAGGGGAACTCCCAGAGGTTAA AAGACAGGGCTGAGTTCTGGGGGATTTGTTTGCTTTTTTACCCTCAGAGTGCCAAGGAGT ACCGACAGCGAAGCCTACTGGAAAAAGAACTGCTTTTCTTCGCTTATGATGTTTTTGGAA TTCCCTTTGTGGATCCGGTGAGCTAGGGTACAGGAGCCGGAAGGGAGCGGGGAAAGAGTG AGCAGGAGAGATGAATGGGGAGGAGGGGAACACTGTGCGATTCTGAGAGAAAACTTGCTG GAGGCTGAGCCTAGCCTGGGATCTGTGCAAGGCAGGGATGAGAGACAGATGAAAGGGGAA CACTGGGCAGCTAGAAGGGACTTAGATGTGGAAACCTCCCATTTTGTCTCCTGAAAGGAA GAGGGTGATAAGCTGGATTACTCCTGTGGGCCTTATTTTATGCATTGAGACACCTGGAAG ATTAAGTAGATCATCTTACCTTTTTCATTTCTTCCTGACCTACTTAGGATTCATGGACTC CAGAAGAAGTGATTCCCAAGAGATTGCAAGAGAAACAGAAGTGAGGACCTTGAAGAAACT GCATGGTTGGATCAGTCTGATGAAGCACTTGAGGCTTCCTGAGCCCAGGCAGATGTGAAC TCCTGGCAAGGGGTGGGCAGGTCCAGTTTGGGAAGTCGGGGTGGAGCCCAGGGCTGGCCC TGGAATGCAGTCCTCAGAGCGGCTGTGCTCATAGGTCAGAACGGGAAACAGCCGTACGCA TCTCCCAGGAGATTGGGAACCTTATGAAGGAAATCGAGACCCTTGTGGAAGAGAAGACCA AGGAGTCACTGGATGTGAGCAGACTGACCCGGGAAGGTGAGAGGACAGAAATAGGGGCAT GTCTGGCTGTTGTCAGGGAGCCAGGCAGGTCACCCCACATTTGCCAGGCAGCGCTCCACC CCAGCATTGCAGAGCTCACCATGAGCCAGCCACCCTTAGGGTGCAAGTTCAGTGGACATC CTTCCTAACTCACCAGCGGGACTTTCAGCTGGAAAGAGCACTGAGAATCAGCCTTTGGCT CAGAAATCAGACTCCAGGATGTAGTGGTGCACACCCGTAATCCCAGCTACTTGGCAGGCT GAGGCAGGAGGATCGCTTGAGCCCAGGAGTTTGAATCCAGCCTGGGCAATATAGCAAGAC CTCATCTTTAAAAAAAAAGAAAGAAATGAGACTTCTGTGTCACAGAAACATGAGTGACTA GTGTTGTCCACTTCCATAGGTATTAACTCATCCTGTCTCCCCACTCCCAAACTGTTTTCT CCCGGTTTTCACCATTCGTCCCTTTACTGAGACTCAACGCCTTCAGGCCTCCTTTGGCTC CTCTTCCTCCTGTGCCCGTTTTCTGCAAGCTGCTGGGAAGGCCTACTGATTGTGGCTCTG CTCTGCAGTGCTTCTCAGCTCTCTCCCCAGCCTTTTCCGTTTTTCATTGCCTCAGGCTTC CTTCAGGCCCTGGCACCTCCTATCTGCACCCACCCTTTCCCCGTCTGGCCTGTCCTTGCC CCTGCCCACACAAGGTAGCTAGGCCAGTCTTCCAGACACTGGCCTCTGACCCATCCTCCG TGCCTGCCCCTTAACCGAATGTTCTACTCTTGTCCTGTTTACACCGTCTCTTCACACAGG ACTGCACTTTGTTCCGTGAGCCCGCCCACTGCCCACCAGTCTGTGTTTATGCCTGGCTCT CCTAGTACGCTTCCCACCATCCCTGCCCATGAGGGCATCTGAGATATACCCTGCAAAGCC TTTCTTTTTTTTTTTTTTGGAGATGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTG GTGCAATCTTGGCTCACTGCAACCTCCACATCCCGGGATCATCAAGGAATTCTCCTGCCT CAGCCTCCCAAGTAGCTGGGATTACAGGCATGTGGCACCATGCCTGGCTAATTTTTTTGT ATTTTTAGTAGAGATAGGGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTT GTGATCCACCCGCCCTGGCCTCCCAAAGTGCTGAGATTATAGGCATAAGCCACTGTGCCC TGCCGTAAAGCCTTTCTTAACCTCCCAGATGATTGGAGTCCCCTCCTTTCTTTTGAACTT CTTAGGGCATTTATGGTCTGTCTTATGCTAGTTATTTGCATAATTGTTAGAGAACAGGTA CTGTCTTCTAGGATTCATCTCTCACCCTATCTGGCACAGTTCCTGGTACACACTGAGGCC TCAGTTATCAAGTGGAGTTGAACTGAGTCTCTAGTATTAGTATGTCCCTAGCACAGAGAA ACACCATGAGAACTGTAAGAGAGAAATGTTGACCTTTGCCCTATAGTTGCTTAAATTAAC AGTGGTTAATTAAACAAGATTAGCGTATGAAAAGAATTTGTCCAGCATTCCTTTGTTTTC AGACCACTTTCACTTTGTTATTTCTCTTGATTCTTATAACTGAGAGGTGAGTCATGCAGA TTGCAAGATCCTTATTTTAAATGAATAATGATGATGATACCATGGTAGCCAAACTTTTGA GGACTTACCATATGCCAAATATTGTACTAAGCTTTTAACTTGCCTTCCTTGTTCTTAACA TTATACTGGCATCAAACATATAAGGTAGATGCTGTTTGACAGATGAGAACATTTTAATTA ATTAAAATTAACCTCAGGGAGGTTAAGTAACTTGCCAAGGTCACACAGCTAATCAATGGA GGATCTAGGAGTCAAAGTCAGTTCTTCCTCGTTCCCGAGCTCATGTTTTAGGATTGTGTT TCTGATGTTTCCTCAAGAGTGTGTCATGGCCCAAAAGCCAGCAGCTATTTGGTCATGGAG CTGGGACTGGGAATCTCATCTTTCAGCTCTATGTTCTGTCCTCTGGACTATTCTACCTTT GAAAATGACCTAGCGGGAGATTTTGCTGGTGAAAAGGAAACAGCTGGAATTTCTATTTGT GACGAGGAGGCAATATCCAATGGAGAGTCTTTGGTCTAGCTGCTGCTAGATTTAGCTAGA GTTTTGTCATTGCTTTGCAGGTGGCCCCCTGCTGTATGAAGGCATCAGTCTCACCATGAA CTCCAAACTCCTGAATGGTTCCCAGCGGGTGGTGATGGACGGCGTAATCTCTGACCACGA GTGTCAGGAGCTGCAGAGACTGACCAATGTAAGGGAAGCCCAGTGACTGCACCTTCCCCC AAGGGTCCAGCATCCCCCCACCAAGTGCCCCTTGGGTGGTAGCCTTCGCCTTCCTCTTCC TGGCCACAGTTGACCACCTCTTCTCAAGCCCTCAGCTGCCCTGGCTAACATCACCTTGTG TTTTGGGCCTTGTAGGTGGCAGCAACCTCAGGAGATGGCTACCGGGGTCAGACCTCCCCA CATACTCCCAATGAAAAGTTCTATGGTGTCACTGTCTTCAAAGCCCTCAAGGTAAGATCA ACACTGGGCATTCTAGAGTGTGGAGAAAGGGGTGGGGAAGGGGGAAGCTCAGGCTTTGAG GAAGAGTTGGGGCTGGTGGCAGGAAAGGTGAAGAGGGTCCACCTGCCAACATTCTTGTTG CCAGGAAGCGAGGATGAGTTATGTTGCGTGAGGTTCACTTTTGAATCCTGTTAGACCGAG TGTAATCAAAACAAAGTGAGCAGGATAAGACTGTTCGCCAAAGCTATGAGAATGCTTTCT TTAGAAAGGCTGATTCTAGAGGGCTGTGCTTCTGTGCAGGATGCACAGTGTGCTCATAAA GAGAGATAAGAAGGACAGGAGGAAGAGGAATATAGTAGGGGTATTGGGCGTGGGCAGCAG AGGCTGCAGCTTCAGTGGGGGTGTGGGGACGTGGGATGGGCCTGGTACTCATTGTCTCTG GCCCCTAAAGAGGGGCGTTGTGTTAGTCCGTTTTCACACTGCTGATAAAGACGTACCCGA GACTGGGCAATTTACAAAAGAAAGAGGTTTACTTGGACTTACAGTTCCATGTGGCTGGGG AAGCCTCACAATCATGGTGGAAGGCAAAGAGGAGCAAGTCACATCTTACATGGATGGCAG CAGGCAAAGAGAGAACTTCTGCAGGCAAACTCCCATTTTTTTATTTTTTATTTTTTATTA TTTTATTTATTTATTTATTTATTTATTTATTTTTTTTTTATTGATCATTCTTGGGTGTTT CTCGCAGAGGGGGATTTGGCAGGGTCACAGGACAATAGTGGAGGGAAGGTCAGCAGATAA ACAAGTGAACAAAGGTCTCTGGTTTTCCTAGGCAGAGGACCCTGCGGCCTTCCGCAGTGT TTGTGTCCCTGGGTACTTAAGATTAGGGAGTGGTGATGACTCTTAACGAGCATGCTGCCT TCAAGCATCTGTTTAACAAAGCACATCTTGCACCGCCCTTAATCCATTTAACCCTGAGTG GACACAGCACATGTTTCAGAGAGCACAGGGTTGGGGATAAGGTCACAGATCAACAGGATC CCAAGGCAGAAGAATTTTTCTTAGTACAGAACAAAATGAAAAGTCTCCCATGTCTACTTC TATCCACACAGACCCCGCAACCATCCGATTTCTCAATTTTTTCCCCACCCTTCCCGCCTT TCTATTCCACAAAACCGCCATCGTCATCATGGCCCATCCCCAATGAGCCGCTGGGCACAC CTCCCAGACGGGGTCGTGGCTGGGCAGAGGGGCTCCTCACTTCCCAGTAGGGGCGGCCGG GCAGAAGCGCCCCTCACCTCCCGGATGGGGCGGCTGGCCGGGCGGGGGGCTGACCCCCCC ACCACCCTCCCGGACGGGGCGGCTGGCCAGGCAGAGGGGCTCCTCACTTCCCAGTAGGGG CAGCCGGGCAGAGGCGCCCCTCACCTCCTGGATAGGGCGGCTGGCCGGGCAGGGGGCTGA CCCCCCCACCTCCCTCCCGGACGGGGCGGCTGGCCGGGCAGAGGGGTCCTCACTTCCCAG TAGGGGCGGCCGGGCAGAGGCGCCCCTCACCTCCCGGACAGGGCGGCCGGCCGGGCGGGG GGCTGACCCCCCCACCTCCCTCCCGGACGGGGCGGCTGGCCGACCACCCCCCCCGGCCTC CCTCCCGGACGGGGTGGCTGGCCGGGCTGAGGGGCTCCTCACTTCCCAGTAGGGGCGGCC GGGCAGAGGCGCCCCTCACCTCCCGGACGCAAACTCCCATTTTTTTAAAGCCACCAGATC TCGTGAGACTTATTCAGTATTATGAGAACAGCACGGGAAAGATCCACCCCCATTATTCAG TCATCTCCCACCAGGTCCCTTCCACAACACATGGGAATTATGGGAACTACAAGATAAGAT TTGGGTAGGGACACAGAGCCAAACCATATCAGTCGTTGAGGGCAGCTGACCATCTGTCTC CTTGGCAGCTGGGGCAAGAAGGCAAAGTTCCTCTGCAGAGTGCCCACCTGTACTACAACG TGACGGAGAAGGTGCGGCGCATCATGGAGTCCTACTTCCGCCTGGATACGCCCCTCTACT TTTCCTACTCTCATCTGGTGTGCCGCACTGCCATCGAAGGTGGGCCTCATTACCCCTGCA GCACCCGCCCCCGCATGCTGTACCTCAGCTCTGTGCTGGATGCTGAAGACACAGAGAGAA CAGGATGCGGTCCCTTTTCTTCAGTTGGGGAACCAATGTAAATACATGGGTGGCATCCCA GTGTGATGCATGCCACAGTAGCATGGAGGAAGTTATAGTCAACCTACCTGGGGATCAAGA AGGCTTCCCAGAGGGAAATGGGGTGCAGCCAGAAAGGGGGCCACCCGTCACTTGTCACAC AACGCACTTTAATGGGGAAGCTGGTGCTAAACCATTCATAGAGGACCTGCCTCCGGGTTA GGGTTTCATACATAGCTGAGCAGCTCCCTCGCTGCCATCTGTTGAAAGACAGCCCTCAAC AGAAGGGCTTGTTAAAAGCAAAAATAATAACAACAACAACAACAACAAAAAGAAGGCTTC CCAGAGGAAGCAATGGCAGTTTTGCAGGATGAATACGATTACGGAGTACTCCGGGTGGTG GGATGGTGTTTGCACAGGAGTGGAGGCATTGTGCAGCCTGGTAGTCAGGGGAACTAAGAA AGGTGCCAAATCCTGGAGAGCTACATTCAAGGGAATTTTTATCCTTTAGCTCAACCATAG CTATGTGGCAGATTCTCTTTTACTAATTGTTAAATACCAAATTTGTGAGAGAGCTTCGTG ATTTACAAGTGAGAGTGGCCTGGAGGTTATTCCTCATTCCCTCGCCCACCCACATTCCCT TTTGCATGTCCAAGAAGGGGAGAGGTTCAGCTAGTGCTGCAAGGATCCTATGTGGCCCAG AGCCGGCTCTGTCATACTGGAGCCTCCAGCAGGCCCCTGGCAGTGATGGCCATTGGTACG TGGCACAGATCAGAGGGCTTTCCTCTACCTCAGAATGTTTGGAATTCTGTCACAATCTGG GCACACCCAAAGGGACCAGTCAGACACACAACTGGGTGTGTCACAAGCCCCCGGTGGGAG AGCACAAGCACAGGTGCCAGGAGGCCAGGGAGGCCTCATCAAGCAGTGAAGGACGTGGTG AGGCCTTGACTTTTAAAGGATTCATTTTGCTGCTGTGTGTGTGGAGAGATTTCAAACCAA AAAGGGAAGCTGGTCAGCAATGACCTCTGTGGACAAGGGCAAAGCCCTAAACTCAGGAAG TGGCAGTGGGAGGAGGGAGAAGTGAGGCCCCGGGAAGGTGCAGGAGGTGGATGGACAGGA CCTGGTGACTGGCTGGACAAGTGGGAATGGAGAAGGAGGCACCCACCACGACGTGACGGT GCCTACATAGAGCATGCCAAAGGTTTGCGTTGGGGAAAGACGTGGTCTGCCTGGCATTTG ACAGTGAGCCCGGTCTGTTCCCTTTCGTGACCTTCTCCCTGCATGGTTTCTCCACCCACC CCACCCCAGAGCCCCACTGAAGTTCATGCTTTCCCTTTGCTAGCCAGCTCTTCTCTGCCC CACTTCCTGCCACTCAGCCCCATCTCCTGCAGTCCTGATGGAGGACTGACCCACTCTGCC CTGCGTCCGTCCCACCTCCTGATCCCTCATTCTCACTTCCCTGGGCCTTTGTATTTTGTA AAGTCCAGCTACAAACCAGGGTTGTGCCATTCTGCCCAGGATCTGCCCTTGGTTGGAGCC CTTCATTCCTGCTTGCCACACCCTGCTCACTTCTGCCAAGAACTGTCCTAGGAAGCCTGC AGACTTGTCCTGACCCCTAGGCTTGTGGCTTAGCCAAAGACACCCCCCTAGTTCATTGGG CATTCCGTAGACTCAAACACATTTTGGGAAGCACCTCCCCTGCCAAGAAGAGAGCTATGC CGTCTCCCGAGGTGCTCCCTTGCTAACATGTGTGACATTGGCCCCAGAGGTCCAGGCAGA GAGGAAGGATGATAGTCATCCAGTCCACGTGGACAACTGCATCCTGAATGCCGAGACCCT CGTGTGTGTCAAAGAGCCCCCAGCCTACACCTTCCGCGACTACAGGTGAGTGCGGGGCAG GTGCAGGGTGAGGAGGTCTGTGCCCTCCTCAGAGGCCCCACAGTGCCCTGCACTCTACTA CCCCACCCTAGCACACACACACTGGTTGGGGCTAGCTGTTCCCAGAGTCCAATCCTTTAT CCCCAAACCCGCTGGATAAGAAGATAGGCAAAGAGGGAATCATATCGTGGTGTGACAAGA ACGGTAGTGTGAGTGGGCACAGGGGACTCTAAGGCGAGGGTGGAGAGTGGAAAGGTGGAG TTTGTACGGCATCAGTATAGGTTCTTAAAGGTTTCCCTCCCACACAAAGCCACCCTCCTG CTGCTGGTTGAGAGCACCTGGAGGTGAAGGCTCAGGGGAAAGGGAGGCAGGGAAGGGCCA TGATGAGATGTCTCTGCCTTTCCCAGCGCCATCCTTTACCTAAATGGGGACTTCGATGGC GGAAACTTTTATTTCACTGAACTGGATGCCAAGACCGTGACGGTGAGTGCTCCCTTGTCC TTGTCCCTGGGAGATAAAAAGTCTGTTTTCTACAGCTGATGTTCCCAAAGTGCAGTGGAC AAAAATAACCAACTGGGCTTCCCAGTGGGCGGTACCCTTCCCCCATCCAGAGGGGCTTTG AGACGTGTCCATCACTCCTCTAACCAGTCACCCTTTCTCTTTAGTTCTGGTCTTAGGGAA GCCATACTGAAGAGCTGCCCTCGGTCGTGAGCCCTAATGAGCCCATGTCTCTTCTGAGAG TGGATTACAGTCTTTGTCCTGTGCAACCCCCCTCCCTTTCTGTCCCCCTTAGGCAGAGGT GCAGCCTCAGTGTGGAAGAGCCGTGGGATTCTCTTCAGGCACTGAAAACCCACATGGAGT GAAGGCTGTCACCAGGGGGCAGCGCTGTGCCATCGCCCTGTGGTTCACCCTGGACCCTCG ACACAGCGAGCGGGTGAGAGCAGCTCGAGCGGGTGAGAGCAGCTGGTGCTGTGGTGACCC GTTCCCAGAGCGCCCTTGGTTTGCCTTTCTCTTCCCCAAATCCCATTGCCAGTGGCTGAG ACACGAAAGGAGCACTTGGGACACCAGCTCCAACGCCCTGTCATTATGGTCACATTGCCT TGTCCTCCCTGGGCCTGCTGTGAACGGGATCCAGGTGGGGAAAGAGGTCAAGACAGGGAG CGATGCTGAGTTCTTGGTTCCCTCCTTGGGCCCCACTTCAGCTGTCCTTTTCCAGAGAGT AGGACCTGCTGGGAAGGAGATGAGCCTGGGGCCATTAAGGAACCTTCCTTGTCCCCTGGG AAGTAGCAGCTGAGAGATAGCGAGTGTCTGGAGCGGAGGCCTCTCTGAATGGGCAGGGGT TTGTCCTTGCAGGACAGGGTGCAGGCAGATGACCTGGTGAAGATGCTCTTCAGCCCAGAA GAGATGGACCTCTCCCAGGAGCAGCCCCTGGATGCCCAGCAGGGTCCCCCCGAACCTGCA CAAGAGTCTCTCTCAGGCAGTGAATCGAAGCCCAAGGATGAGCTATGACAGCGTCCAGGT CAGACGGATGGGTGACTAGACCCATGGAGAGGAACTCTTCTGCACTCTGAGCTGGCCAGC CCCTCGGGGCTGCAGAGCAGTGAGCCTACATCTGCCACTCAGCCGAGGGGACCCTGCTCA CAGCCTTCTACATGGTGCTACTGCTCTTGGAGTGGACATGACCAGACACCGCACCCCCTG GATCTGGCTGAGGGCTCAGGACACAGGCCCAGCCACCCCCAGGGGCCTCCACAGGCCGCT GCATGACAGCGATACAGTACTTAAGTGTCTGTGTAGACAACCAAAGAATAAATGATTCAT GGTTTTTTTTACTTGGTTTGTTCAGACAATGGAAATTTGCCCATTCTGTC OMIM ID 610339