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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for SEMA4A (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID64218
Official gene symbolSEMA4A
Full namesema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
Aliases,CORD10,FLJ12287,RP35,SEMAB,SEMB,
Gene summaryThis gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
LocationChromosome: 1   Locus: 1q22
Gene position156119735 - 156147542  Map Viewer
Gene orientationplus
Gene size27808 bp
Gene sequence
OMIM ID607292