Entrez gene ID | | 64332 |
Official gene symbol | | NFKBIZ |
Full name | | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta |
Aliases | | ,FLJ30225,FLJ34463,IKBZ,INAP,MAIL, |
Gene summary | | This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
Location | | Chromosome: 3 Locus: 3p12-q12 |
Gene position | | 101546834 - 101579869 Map Viewer |
Gene orientation | | plus |
Gene size | | 33036 bp |
Gene sequence |
| |
OMIM ID | | 608004 |