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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for MMP25 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID64386
Official gene symbolMMP25
Full namematrix metallopeptidase 25
Aliases,MMP-25,MMP20,MMP20A,MMPL1,MT-MMP 6,MT-MMP6,MT6-MMP,MT6MMP,MTMMP6,
Gene summaryProteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. [provided by RefSeq]
LocationChromosome: 16   Locus: 16p13.3
Gene position3096682 - 3110727  Map Viewer
Gene orientationplus
Gene size14046 bp
Gene sequence
OMIM ID608482