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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for SHMT1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID6470
Official gene symbolSHMT1
Full nameserine hydroxymethyltransferase 1 (soluble)
Aliases,CSHMT,MGC15229,MGC24556,SHMT,
Gene summaryThis gene encodes the cellular form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in 2 transcript variants encoding 2 different isoforms. Additional transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq]
LocationChromosome: 17   Locus: 17p11.2
Gene position18266856 - 18231187  Map Viewer
Gene orientationminus
Gene size35670 bp
Gene sequence
OMIM ID182144