Entrez gene ID | | 64963 |
Official gene symbol | | MRPS11 |
Full name | | mitochondrial ribosomal protein S11 |
Aliases | | ,FLJ22512,FLJ23406,HCC-2, |
Gene summary | | Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that contains a high level of sequence similarity with ribosomal protein S11P family members. A pseudogene corresponding to this gene is found on chromosome 20. Sequence analysis identified two transcript variants that encode different protein isoforms. [provided by RefSeq] |
Location | | Chromosome: 15 Locus: 15q25 |
Gene position | | 89010684 - 89021495 Map Viewer |
Gene orientation | | plus |
Gene size | | 10812 bp |
Gene sequence |
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OMIM ID | | 611977 |