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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for BMPR1B (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID658
Official gene symbolBMPR1B
Full namebone morphogenetic protein receptor, type IB
Aliases,ALK-6,ALK6,CDw293,
Gene summaryThis gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. [provided by RefSeq]
LocationChromosome: 4   Locus: 4q22-q24
Gene position95679128 - 96079601  Map Viewer
Gene orientationplus
Gene size400474 bp
Gene sequence
OMIM ID603248