Entrez gene ID | | 6605 |
Official gene symbol | | SMARCE1 |
Full name | | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 |
Aliases | | ,BAF57, |
Gene summary | | The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart. [provided by RefSeq] |
Location | | Chromosome: 17 Locus: 17q21.2 |
Gene position | | 38804103 - 38783972 Map Viewer |
Gene orientation | | minus |
Gene size | | 20132 bp |
Gene sequence |
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OMIM ID | | 603111 |
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