Entrez gene ID | | 6764 |
Official gene symbol | | ST5 |
Full name | | suppression of tumorigenicity 5 |
Aliases | | ,DENND2B,HTS1,MGC33090,p126, |
Gene summary | | This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. [provided by RefSeq] |
Location | | Chromosome: 11 Locus: 11p15 |
Gene position | | 8932498 - 8714899 Map Viewer |
Gene orientation | | minus |
Gene size | | 217600 bp |
Gene sequence |
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OMIM ID | | 140750 |