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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for ST5 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID6764
Official gene symbolST5
Full namesuppression of tumorigenicity 5
Aliases,DENND2B,HTS1,MGC33090,p126,
Gene summaryThis gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. [provided by RefSeq]
LocationChromosome: 11   Locus: 11p15
Gene position8932498 - 8714899  Map Viewer
Gene orientationminus
Gene size217600 bp
Gene sequence
OMIM ID140750