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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for ST14 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID6768
Official gene symbolST14
Full namesuppression of tumorigenicity 14 (colon carcinoma)
Aliases,HAI,MT-SP1,MTSP1,PRSS14,SNC19,TADG15,TMPRSS14,
Gene summaryThe protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. [provided by RefSeq]
LocationChromosome: 11   Locus: 11q24-q25
Gene position130029682 - 130080257  Map Viewer
Gene orientationplus
Gene size50576 bp
Gene sequence
OMIM ID606797