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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for STAT6 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 6778 Official gene symbol STAT6 Full name signal transducer and activator of transcription 6, interleukin-4 induced Aliases ,D12S1644,IL-4-STAT,STAT6B,STAT6C, Gene summary The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants. Location Chromosome: 12   Locus: 12q13 Gene position 57505196 - 57489187  Map Viewer Gene orientation minus Gene size 16010 bp Gene sequence >STAT6:complement(19632493..19648502):Length=16010 AGAGCTCCAGGGAGGGACCTGGGTAGAAGGAGAAGCCGGAAACAGCGGGCTGGGGCAGCC ACTGCTTACACTGAAGAGGGAGGACGGGAGAGGAGTGTGTGTGTGTGTGTGTGTGTGTGT GTGTATGTATGTGTGTGCTTTATCTTATTTTTCTTTTTGGTGGTGGTGGTGGAAGGGGGG AGGTGCTAGCAGGGCCAGCCTTGAACTCGCTGGACAGAGCTACAGACCTATGGGGCCTGG AAGTGCCCGCTGAGAAAGGGAGAAGACAGCAGAGGGGTTGCCGAGGTGAGGGGTTGCCTC CGAGGTGGGTGCGGGGGCCTCTATGAGTGCATGGGGGTGGATTCGTGGGGGGAGCTCTCG GGATCCTCCCCTGGCTGGGTGGATGGTCCCCAAGAGATGGTTTCAGCTAGTGTTGGTGGC TGGTGGCACTGGGTTTTAGCAGTTTCGAACTCCTGGAGGAATCTGGGAGGGTCCAGGCCT CAGTACTCCCCTCCCCCATGGGTCACGTTTTCACAGCCTCACCCCTGCACCCCCAGGGCC ATGGAAAGTCAGGGAAAGGAGGTGAAGGAGTGCCCCTCTGCCCTGAGTCGGGGGAAGTGG CCGCCCCTCCCTGGAAGGTTGATGCCAGAGGGCAGTGGATCCTTGTTAAACCCCTATCCT GCCCTCCACTAAAGGTTCCTGTTCAAGGGTGTGGCTGGGGCGTGAGCAAGCCCCAGATGT AGACCTCATGGTGGCCCAGACGAGGGGGAATTTCCCCCTCAAAACTGCTCCACGCTTGGC TGCTGTAGACGCTGAGATTTCCCAGCGGCGGCGCCGAGTTAACCCTCCTCGTGCTGAACT GGCTCCACCTCCCCGCCTGCCCCCACCGCCACATTCACGCATTGGGCAACTCAGAGAAGC TGTTTTAACTTTCGATCCTGTGGTCCCACAATCAGAGGACTCGGGCAGATAGGGGTTGAG ATAAGCGAGTTTAGGCCACCAAGCGGGCGGACGAGGATCCCAGACCTTGCGCTTCCCTTC TGAGTTTGGGAGGTAACACTGGCCCCGCCCCTCACGCCGTGGCTCCTCCCTCCCTTCCCC TTCAAGGGGCTGAAGACAAAAGGTGCCCCTGTCCTGGTCAAGCCAATCGACCCAGCCTTG TTATGGGTTGGGGTGGGGAGAAATGTGTCCTCCTGATGGCTGGGGAAGAAGAGGGGTTGG ATATTTCTAGCCAGGGCCATGCCAGGAGGCTGGTCACTCTGCAAGGGGATGCAGAGGAAA GCGGTGCCCACTCACTCCAGAGGACCTTTCTCTCTTGGGCTAGAGAAAGGCCTATTGGAG GAACCTGAGCAGGAGGGGTAAGGATTCTGCCTTGAGGAGAAAAGAGCTGGGGTAAGTGGG CACTGGAGGAAAGAGGGGCATGAAGGTCTTGGAGCAGAAACGTCCAGAGAAGGGACCTCT CCATTTTCCATCCCTCTGAGAGGCCTGGGAGAGGTGAGAGGCTGAACGTGCAACAGGAGG ACTTGGGGTTACTGGGTTTGGGGAGACCTGGGGAGTTGTCATCCCATCCTCTCCCTCATC TCTGGGAGAGGGATATTATGAGAAACGTGAACTGAGAGGCCCCTGGGAAACCACTGGTTA CCCAGTCCTCCCTGAACCTGGAAATGGGGATGCAACCCCCTCTTCTACTTCCCTGTCCCC TCCTCTCCTTTCTACCTGTTTTCGTCTCTCATCTTTGCCTTCTAGCCCTCCAGCTTCCTC TCTCTTCTAGGCTCTTTCCTCCTAGCTTACTAAACCCGCCTTTTTTCCAGTCTCTTCCAT CCTCTTCCTTAGTTCTCTCTACTTTCCTTTTCCACCTCTCCTCCTTCAAGTCTCCTCCCA CCTTCCCCCACTTCTTAGGATGATCAGATTTGCCCCTGGAAGGGATCCTAACAACACAGT GCGATGGTTAATCCCCACTCAGATTCAAAGCCTGCTTTCCAAACTCACTTACTGAGTGGC CTTGGGCAGAGTAGAGAAACTCCTTAAGCCTCAGTTTCTTCATCTATAAAATGGGATATT ATATATTTTAAAAAGTGTCGTGAGGCCTGAAGGAGATAATACACTGAGTGTAATGCCTCA TACACAGTAAGTGCTTAACAAATAGTAGCTGTTATTACTCTCCCATCCTCTTCATCATCT AGCCTTGTGGTTTTCATTTTTATTTTATTTCATTTATTTATTTATTTATTTTGAGGCAGA GTCTCTCTCTGTCGCCCAGGCTGGAGTGCAGTGGCTCGATCTCTGCTCACTGCAAGCTCC GCCCCCCAGGTTCACGCCATTCTGTCACCTCAGCCTCCCCAGTAGCTGGGACTACAGGCG CTCGCCACCACGCCCTGCTAATTTTGTTTTTGTATTTTTAGTAGAGATGGGGTTTCACTG TGTTAGCCAGGATGGTCTTGATCTCCTGACCTCGTGATCTGCCCGCCTCGGCCTCCCAAA GCGCTGGGATTACAGGCATGAGCCACTGCGCCTGGCCGAGCCTTGTGGTTTTCAAATTAT CTCATGGAGTCCTAGAATTTTGAGAGGTTTGTCTAGGGATGCCTTTGGCGTCAGGAGGTG GGGAGAGGGAAGTAGAAGCAGTCGAGTTTCAGGCTTTCCATGCTTGCTTTCAACAGGGCA TCTTCGGTTTCGTACCTTTTATGTAATTGAGATTCCACAGATTAAAAGCTGACATTGCCT ACCGCTTTAAAAAGTTTGGAAAGTTTTCCACTCATCTAACACTCATATTTTATAGATGAG AAGATCGAAGCCCACAAAGGGAAGGCTCTTTGCCCACAGAACCAGAGCCAGGTCTAGAGC TGCAACTAAATCCTCTGCCACTCTAAGAGAGCTCTCGCTCTACTGCCCTGTCTCCCTTTG CCTCCCCATCCCTCTGGCTACAGCTCAGCTCTTCCCACCCCTGTGTCTATCACTGAAGGA GTTACCCCCATCTCAGGCATTGACTCAGGATGCCCCTGGTTTAAGGTGGTCTGGCCATGA GTGGTGGTGGGGACGGTCCCTAGGAGGGCTATCTATGGGAGGTCCCTGGCTGCCCCAGGA GATAGGCCAAGTTTCTTGGGCACCCCTCAGAGTGGCCTTATTTTTCTCCTCCAGGCAACC TCCAAGTCCCAGATCATGTCTCTGTGGGGTCTGGTCTCCAAGATGCCCCCAGAAAAAGTG CAGCGGCTCTATGTCGACTTTCCCCAACACCTGCGGCATCTTCTGGGTGACTGGCTGGAG AGCCAGCCCTGGTGAGTCCTGGCTGCTCCCTGCTGGTCCCCCAAGTCTTCCCTAACTCAT CTTCCTTCTCCTTAGATTTTTCTCCCCTCACCCATGGATTCAGAACTTGAGACCTGTTAT TCCATGTGTAGTGACCTAGATTTAGCAGGGAGTCTGTGCCCCATCAAGACCAGGCTATGA ATGTTGACAGATGGAGACCCCATCTCTTAGGAGGCTGAGCCGAAGAGGAGGGGGGTTTGG GCTGGGACAAAGGCACTTCTCATAACAGCTAGAAGACTGGGAAACAAGGCGCATGGGTGA AAGCTACAGAGGGCCTAGATGGAGAATAAGGAGCGAGAAAGGAACTGCTGAGCTTTTGGC TGTGGGGTAAAGGGTCAGGAGAGCTGAGGAAGCCCTGGCCTGAGGTAGCCTCATCCTGAT CTTCCTGCAGGGAGTTCCTGGTCGGCTCCGACGCCTTCTGCTGCAACTTGGCTAGTGCCC TACTTTCAGACACTGTCCAGCACCTTCAGGCCTCGGTGGGAGAGCAGGGGGAGGGGAGCA CCATCTTGCAACACATCAGCACCCTTGAGGTGGGGCAGGAGGGGAGGGGACAAGGCTGGG TGGGGCTGAGGTTGAACTGGGTTGAGCATTGGGCCCTGGAAGAAAATTGGTTGGATGCTG GAAGCAAATTGGTGTTCCTGTGGTTAACTGCTAGCTAGCAGGCAAATTAGATTTTAAAAG CATGCAAATGCACAAAAACTTCTGGAGTCTACAGTTGTGCTTCCTTATAGTATATGTGTG AATGCAGGCCTGGGGATTGGAGGGATTGAAGGACATGGGTAAGAGCAAAGCTCACTGTTT ACCACCCTCATTTCTGTAGAGCATATATCAGAGGGACCCCCTGAAGCTGGTGGCCACTTT CAGACAAATACTTCAAGGAGAGAAAAAAGCTGTTATGGAACAGGTATTGTGATATTCCAC CTCCCACCCCAACTCAATCCCCTGAGACTTTGGCCTGAGCCATGACAAACTAGAAAGAAT TTGAACCTCAGTAAAGGCTCAGTGTTCTAGGCCCAGGAATGACCAAAGGAGGTTCCTAGG GTCAGAGTGAACCCCAAGTCAAGCTCAGGGAATCTTTCTATGAGGGACTGAAGGTAAGAG GCCGGGGAGAACAGAGCAAGGGATAAGGAGCTGATTCTGCTAGGAGCAAGGTCTTATCTC CACGATATTCCAAAAGGTCAGGAAGAACTGCCAAAGGGGAGAGGGGAACAAGAAAACGCT ATCTGCAGAGCAGAGAGTGGAGGCCAGGTATAGAGGGATGAGCAGAGTGTTTCACTTCTT GGCATCTGTCCTTCCTGTGTAGTTCCGCCACTTGCCAATGCCTTTCCACTGGAAGCAGGA AGAACTCAAGTTTAAGACAGGCTTGCGGAGGCTGCAGCACCGAGTAGGGGAGATCCACCT TCTCCGAGAAGCCCTGCAGAAGGGGGCTGAGGCTGGCCAAGGTGGGGGCCAGGGTGGTTC TGGGGAGTGTGTAGGAGTGGTTGCCTCTTGGATCTCAACCTTATCTGAACCTCTAATCTG TCTGCACCCTTGATTTCTGCCCCCAACCCTCAGTGTCTCTGCACAGCTTGATAGAAACTC CTGCTAATGGGACTGGGCCAAGTGAGGTGAGTAATGGGCTGACAGGTGGAGACCTTGGTC AAAGTGCAGCTGGAGGGATGGAAGCTAGACCTCAGAAAGACACAGGCTGAAGTAGGGCAA GGGAATGCCAGAGGAGTGAGAAAAAGAGCCGTATCCCAGGAGCTGGGTGTGGAGGCAGCG TGAGGCCCTGGCTCAGGCCCCTCTCTGCCCATAGGCCCTGGCCATGCTACTGCAGGAGAC CACTGGAGAGCTAGAGGCAGCCAAAGCCCTAGTGCTGAAGAGGATCCAGATTTGGAAACG GCAGCAGCAGCTGGCAGGGAATGGCGCACCGTTTGAGGAGAGCCTGGCCCCACTCCAGGA GAGGTTGGGCTAGGGCTGATGGGGAAGAGGGGGCAAGCTGGGGGTGGGCAGCTGACCCTG CTGAAGGCCCTACAGGTGAGAGAAAGAAGCCAGGCGGGAGGGCCTTGGAGTGGACCAAGA TGCATAAAAGCCAGTTCCAGCGGGGCTGTGCACACTGTCGTTCAGGTCGCATCCTGTACA AGTGGGCCTAGTGGAGGGGCACAAGCGGGGACTCATCCAACCCAGGCTTCTCTCCTCAAG CCCCATGCCTAGAGGAATAGGAGGGCTTTTCCATTTGGTTTATTGGGTGGGAACACTTTC CAATTTGCCACAAAGCACTGTAAGTGGTGGCAGTTGTCCTGGGTGCAAGAGCCGTCGGGG GAGAGGCAGCTGGGTTTCCACAGGGGGTGTAGGCACTGAGAATGAACCTCCCACCCAGAC CCTAGGCCAACAGATCACAGAACCCCCTTCAGCCCAGGTGCCTTGCAGCCACACCCACTA CCCACCCCACTTCTCCACACATGATAGCCTTTCTCCCTGGGTATAGGGGAAGGGGGTCTG GGCCGGAGCAAGCAGCCTTAATCCTGTGCCCCCTGACCACTGTCCTGGCCCCAGGTGTGA AAGCCTGGTGGACATTTATTCCCAGCTACAGCAGGAGGTAGGGGCGGCTGGTGGGGAGCT TGAGCCCAAGACCCGGGCATCGCTGACTGGCCGGCTGGATGAAGTCCTGAGAACCCTCGT CACCAGGTATTCCCCGGGAGCTCCCAGTCTGGCCTAGAACAGACCTCGGGAAGAAAAGAA GGGGGCTAGAGCTGTGGGGAGGGCACCAGCAGGGACCTAGCCCCCAACTCCCCTTGTGTC CTCCTCACTCCCAGTTGCTTCCTGGTGGAGAAGCAGCCCCCCCAGGTACTGAAGACTCAG ACCAAGTTCCAGGCTGGAGTTCGATTCCTGTTGGGCTTGAGGTTCCTGGGGGCCCCAGCC AAGCCTCCGCTGGTCAGGGCCGACATGGTGACAGAGAAGCAGGCGCGGGAGCTGAGTGTG CCTCAGGGTCCTGGGGCTGGAGCGTAAGCTGGGATTGGACCTGGGGTTGGAGAAGGGCTG TTAGGGTGATGGAGGCAGCCTGGAGGGCTGGCACTGAAAAGAGCAAGGGATGGGGAGGGA GGGCCATGGGATGTGGAGACCCTGAATGGTCAAGGCAGAGGAAAGGGAGGGACCCATTTA GGGCTGGAATGGGGTGGGGGCATCATGATTTGGCCAAGATGGGGACTCCTCCCTTAAGAA CCCAAACAGAGACATGGAGATTTAGGGCTGGTGACAGTGGGTAGTCTACACTCACCCATG CACTCGCCACACCTGACGACAGTGAGATGAGCTCGTTCACACTCTGACCTCCCCTGGCAG AGAAAGCACTGGAGAAATCATCAACAACACTGTGCCCTTGGAGAACAGCATTCCTGGGAA CTGCTGCTCTGCCCTGTTCAAGAACCTGGTGAGGGGCTTTGGGGTGCAGTGAGGGGGGCA CCACTAGGAGACTGTGGGACTCTCCTTGGAGAGGATGTCAGGAAGCCCAGGAGGAGCGGT CTCTGTCCTCATGACCTCGCCCTTGCTCTCCCTCACCCCACCCACAGCTTCTCAAGAAGA TCAAGCGGTGTGAGCGGAAGGGCACTGAGTCTGTCACAGAGGAGAAGTGCGCTGTGCTCT TCTCTGCCAGCTTCACACTTGGCCCCGGCAAACTCCCCATCCAGCTCCAGGTGAACCGTG GCCCAGCCCTGCCCCAATCTGGGACCCCGAGTCCTCCTCCAATGCCACACACAAGGGCCC TGGACCCTCACCTCTTGTGACTGCCCCATACCCCATGTGTCTGGGATTCATGCACACTGG GGCCCGGGTGAGTGGGGGTGAGCAAGAGCATGGAGTGCACAGGGCAGGGAATGGTAGTGG ATAGCAGCAAACACTTCGGAAGCACTTCCTATAGACCAGGGCACTCTATTAAATGATACA TACGCACATGCGTGCCAGCACACACACGTCTGGTTTTCACAATAACATTATGAGGTAGGC AGTATTATCAGCCTCATTTTATAGATAAGGACATTGAGACAGAGAGTTTAAGTAGTTTGT CCCAGTCACACAGCTAAGTGTTGGAGCTGGTATTTGAAACCTGGAGGTCTGGTTCCATAG CGATGACTAATAACCACTTCTCTACGGTGAGGCCCTGATTGAGCTTCAGAACGCATTTAA TAACATGGCATGAGCTTTTTGATTATGATGTGTGAGTCCAATAACTTCTCTGAGTGCTCA GAGCCAGTCCCCTGAGGAAACTTCTTGCTTCACTAAGAAACCCCTGTCCGGCTGGGCATG GTGGCTCAAGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTAGATCACAAGGTCA GGAGTTCAAGACCAGCCTGGCCAATATGGTGAAACCCCGTCTCCACTAAAAATACAAAAA TTAGCTGGGCGTGGTGGTGCAGGCCTGTAGTCCCAGCTGCTCGGGAGGCTAAGCAGGAGA ATCGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCCAAGATTGCGCCACTGCCCTTCAG CCTGGGCGACAGAGCAAGACTATGTCTCAAAAACAAAACAAAACAACTCAGCACTTTGGG AGGCCAAGGTAGGAGGATCGCTTGAGCCTGCAAGTTTAAGACCAGCCTGGGCTACATAGG GAGATCCAATCTCTACAAAAAATAAAAAATTGGCCGGGCATGGTGGCTCACGCCTGTAAT CCCAGCACTTTGGGAGGCCAAGGCGGGCGGATCATGAGGTCAGGAAATCGAGACCATCCT GGCTAACACGGTGAAACCTCGTATCTACTAAAAATACAAAAAATTAGCCAGGCATGGTGG CGGGCGCCTGAGTCCCAGCTACTCGGGAGGCTGAAGCAGGAGAATGGCGTGAACCTGGGA GGGAGAGCTTGCAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTGAGTGACAGAGCGA GACTCTGTCTCAAAAATAAATAAATAAATAATTAGCTGGATTAGGTGGTACATTTCTGTA GTTCCAGCTATTCAGGAGGCTGAGGTGGAAGGATCACTTGAGCCCTGAAGGCTGAGGCTG CAGTGAGCTGAGATTGCACTACTGCACTCCAGCCTGGGCAACAGAGTGAGATACTATCTA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGGAAAGAAAGAA AGAAAAGAAACCCCTGTCCTCACCCTCTTCAGGCCCTGTCTCTGCCCCTGGTGGTCATCG TCCATGGCAACCAAGACAACAATGCCAAAGCCACTATCCTGTGGGACAATGCCTTCTCTG AGATGGTGAGGAAAGTCCTGGAGTTGGAGGGAACAGGGGCAGGGTGGGTTCTAACATGGG CAGTGGTGCAGGCCTGCTGATGGGGTGGTGGGCATGTTTAAATGGGTGTGACCTTAACAC TTTCTCATGGGCCTGCTTTCGTGCTTCTGACCTCTTTTCACCCCAGTCTTAACAACTATC AGGCCACAGCACTGTAACCTAGAAAAAACAGCATGTTTGTGAGCGATATCAGGGGCTGTG GAGGGGTAGGCCACAGGCAGGTGGGAGGGATGAAGGCCGGCCCGAGGAATAACAAGACGG TAGCCTGCAGTGCTCTCTTCTTCCCCCTTCTCCCCAGGACCGCGTGCCCTTTGTGGTGGC TGAGCGGGTGCCCTGGGAGAAGATGTGTGAAACTCTGAACCTGAAGTTCATGGCTGAGGT GGGGACCAACCGGGGGCTGCTCCCAGAGCACTTCCTCTTCCTGGCCCAGAAGATCTTCAA TGACAACAGCCTCAGTATGGAGGCCTTCCAGCACCGTTCTGTGTCCTGGTCGCAGTTCAA CAAGGTCATTCTCCTGCCCTTTGGACCTCCCACCCCCAAGCTCTTCATCCCTGGGGCACT CAGGGCCTGCTCAGCCTCCATGCAGGGACCTTCCACTGGATTCTCCACAGTGCCCCCTCA GGTCCTTTAGGAAGGCCTGTCATGGACCAGGGAGGAAAAACCCCAGGCCTGGGGGTTGGC TCTGGAGATGCGTTCTCTGACATCCCTGAGGTTTTGGTCTGGGGGCCATCTGTCCTTCCT CTTTACCAGTGACTTGCATGACTCACCCAGGTTGTGTGTAAACAGAGCTCTGATTCAAAG TGACTTTGACCTGTTGGAAAAATAGTTCCTGGCCGGGCACAGCGGCTCATGCCTGTAATC CCAGTCTTTGACATGCCGGGGTGGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCT GGCCAACATGGTGAAACTCCATCTCTACTAAAAATACAAAAATTAGCCAGTTGCGGTGGC ACATGCCTGTAATCCCAGCTACATGGGAGGCTGACGCAGGAGAATTGCTTGAACCCAGGA GGTGGAGGTTGCAGTGAGCTGAGATCATACCACTGCACTCAAGCCTGGGTGACAGAGCAA GACTCTGTCTCAAAAAAAAAAAAAAAAAAAGGCCAGGCATGGTGGTTCATGCCTGTAATC CCAGCACTTTGGGAGGCCGAGACGGATAGATCACCTGAGGTCAGGAGTTCGAGACCAGCC TGGCCAACATGGCAAAACCCCGTCTCTACTAAAAACAAAAAAATAGCCAGGAGTGGTCGT TTGCGTCTGTAATCCCAGCTACTCGGCTGAGGCAGGAGGTGAACCCAGGAGGTAGAGGCT GCAGGGAAGATGAAACCATTGCACTCCAGCCTGGGCAAGACTCTGTATCAAAAAAAAAAA AAAAAAAGGCTAGGTGTGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGGC GGGCGGATCACAAGGTCAAGAGATCGAGACCATCCTGACCAACATGGTGAAACCCCGTCT CTACTAAAAATACAAAAATTACCTGGGCATGGTGGCGCATGCCTGTAGTCCCAACTACTC GGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGGCAGAGGTTGCAGCGAGCCAAGA TTGTGCCACTGCACTCCAGCCTGCCAACAGAATGAGATTCTGTCTAAAAAAAAAAAGAAA GAAAGAAAGAAAGAAAAAGAATTCCTGTTGCAAAAACTGAACAAAATCCCACAGGGACAT GTGCAGTAATACCAGCTACCACGTGTTGACAGCTTATATGCCAGGCGCTGTGCTTAACAC CTTATGTATGTTATCTCACTTAATCCTCCCAACATCTCTTTGAGGTAGATACTATTATTA TCCCCATTTTACAGATGAGGAATCTGATGCTCAGAGGGTTATGTAGTTTGTTCAAGTTCC CAAAGCAGGTGAGTGCCATGGCTAGGAGAGAACCACATATTTCTGACTCTTGCTCTTTTA TTTTATGTTATATTATGTTATTTTATGTTTTGGTTTTTTTTTCTTTTCTTTCTTTCTTTC TTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTCTTTCTTTCTTTCTTTCTTTCTTTCTT TCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTCTTTCTCTTTCTCTCTTTTTCTTTC TTTTGTGTGAGACAGAATCTTTAAAGAGAAGAAAGAAATGCTCATGTGACCAGAGGGTGT GTTAGCTAAAGGGAGCAAGACAGTCACACCCAGCAGGTTACCTTCCTTTGGGCGTCACCT CTGCCACACCTCCTTAGGGAGAGGGTGTAGCATAGTAGTTAAGAGGGGCTCCAGGGCCAG AATGCCTGGGTTTAAATCCTAGCTCTGCCTCTTACCAGCTATGTAGACCTGGGCAAGTCA TTCGACGTTTTTGGACTTCCATTTCTTCATCTGTAAGATGGAATTATTATAATCCCTACT TCCATAGCCTGGTAAAGAGCAAATAAATATATGGAAAGGCTTGAAATAGTGGCTGGCACG TGTAAGCATTAGGATTGGTCGTTGTCATTGATGGAGTCTCAGGTTCGGTCTGATCCTCAG CCCTGTGATTCTGTCGTGAGGGCACTCACAGCTCACTGCCTGCCCTAAACAGGCTCCAGC TCTGGCCCTCCCTCGGCTCACACCTTTCCCCCTCTCCCCCTAGGAGATCCTGCTGGGCCG TGGCTTCACCTTTTGGCAGTGGTTTGATGGTGTCCTGGACCTCACCAAACGCTGTCTCCG GAGCTACTGGTCTGACCGGTGAGTCCCCACCCTGGGTAGTCTGAGCAGCCATACACCAGT CACCTCCATACTCACTGCCCATGCCCCATCCTCTCCTTCATCCCGGCCAGGCTGATCATT GGCTTCATCAGCAAACAGTACGTTACTAGCCTTCTTCTCAATGAGCCCGACGGAACCTTT CTCCTCCGCTTCAGCGACTCAGAGATTGGGGGCATCACCATTGCCCATGTCATCCGGGGC CAGGATGGTGAGGCCACCCCAGCCAGTCCTCTGTCTCTGTGCCTGTGCCCTCTGGGGTTT CTTCTGGGAATGAAATGTCCTGACCTTCCTGATGCCGATCCTGATCTTCAGGAAGTTCTT CCAGCTTCTCTTCTTCCTTCTGTGGTCTAAATGTTCACCTTCTCACTGTGAGCTCTGTGG GAACGGAGACTAGTGGGTCTCTCTCCCTCAGGAGCCCCACCCTAGGTCCTCTCTCCCTTG CCTTGGTGGAGTGAGAACAGGTCTTATGGTAGGGGTTGGGGAAGGGGAAGAAAGTCCGGA CAGAGGGATCTCAGGGTCTCCTTCCTACCATAGGCTCTCCACAGATAGAGAACATCCAGC CATTCTCTGCCAAAGACCTGTCCATTCGCTCACTGGGGGACCGAATCCGGGATCTTGCTC AGCTCAAAAATCTCTATCCCAAGAAGCCCAAGGATGAGGCTTTCCGGAGCCACTACAAGC GTGAGCTGGAACTGGCAGCTCTGATTCCTTCCTGTCACCCACTTCCTCCCTGCTCCCCGC TGCCCTCCTCTCCCTGCCCGCGTGTCATCCTGATGTCACTCCCTATTTCATAGCTGTGCT TCTCTTACTTCCCCATGATCCATGCCCACCTTTTCCACCTCCCTTCCTCCCTAACCCCAG AGCACTCCATGGCTGTCTTTTCCTTCTCACAACAGCTGAACAGATGGGTAAGGATGGCAG GGGTTATGTCCCAGCTACCATCAAGATGACCGTGGAAAGGTGAGTGTGGTGGTATGGACA GTGGGTAGGTCAGGGGCTTAGTGCTTATCTGCAGGAAGGAGGGGTGGCATCAACCCTTGG TCAGTCACATGTACCTCCTTCCCTCCTCCAGGGACCAACCACTTCCTACCCCAGAGCTCC AGATGCCTACCATGGTGCCTTCTTATGACCTTGGAATGGCCCCTGATTCCTCCATGAGCA TGCAGCTTGGCCCAGATATGGTGTAAGGAGCTGGAAAGACAGGAATGGGAGTGGTCTGTG CAGATGGGCTAATCTTAGCATGGGCAGCTGGGAGAGCTGGCACTGGGGGCTGAACAGGGA ATCTTCCTTTCCATGAGAGGGACACCTGTTCAAAAGCAGGGTGTGGTGGTGTCCAGGAGA AGGGCTGGCATCAGGGGGTCTGTTTTCTTTCCCCAGGCCCCAGGTGTACCCACCACACTC TCACTCCATCCCCCCGTATCAAGGCCTCTCCCCAGAAGAATCAGTCAACGTGTTGTCAGC CTTCCAGGAGTAAGTGAAAAACCTCATGGGGATACCATCCCACTCTAAGGGGGTGGGCAT TTGAATTGTTAGAAGAGGCTCTTCTGTGAGAAAGGAGCAGCAAATGCTAACAGCCTGTCT TCTTCTCTTCTGTCCACTCTAATGAGGGGGTAGTAGTTAAGATCTGGACTGCCTAGGTTT GAATTCTAGCTCCACCACTTACTGGTTTGGGGCAAATTACTTAGCCTTTGGTGCCTTATC TGCACAATGGGGGATAATAATGCTAATAATAATAACCTACCTCACTGCATTATTGTGGAG ATTAAATGAGTTCATAACACTTAAAAAGCTGAGCATAGTGCATGGCTCATAGCAAAAGCT GTGTAAGTCCAGTCGTGGATCACTTAATGAAGGAGCATTTTCTGTCTTTGGCAGTTTCAT AATTATGCGAATACCATTGAGTATAATTACACAAACCTAGATGGTATAGACTACTATACA CTGAGGCTATATTGTGTAGCCTATTGATCCTAGCTTTAAACCCGAGCAGCATGATACTGT TCTGAATAGTATAAGGAAATAGTAACATAATGGTAAATATTTGTGTGATAGGAATTTTCA GCTTGATTATAATTTTTTTTTTTTGAGACAGGGTCTCACTCACTGGAGTGCAGTGGTGCG ATCTTAGCTCCCTGCAACCTCCGCCTCTTGGGCTCGAGCAATCCTCCTGCTGTAGTGCAC CACGACACTCGGCTAATTCTTTTTTAAGATTTTTCTGCAGACAAGGTCTCACTTACTGCC CAAGCTGGTCTCAAACTCCTGGGCTTAAGTGATCCTCCCACCTCGGCCTCCCAAAGCGTT AGGATTACAGGCGTGAGTCACTCTGCCTGGCCTTGATTATAATCTTATGGGACCACTGTG GTCTGTAGTTGACAGAAATGTCGTTAATGTGGTGCATGACTGTTATTATTATTTTCTGTC CTGCCCCTGAGAGCCACTGTCACTTCTCTGCTGTATTGGTTTTTGTTTACTCATCTGTTT TGGCCTTGAAATGGCCTAGACATTTTTCTTCCCGAAGTATGACACTCGGGTGCTTATTAA CTTAGTCAAGACACAACATCTCCCTTCCCAGAAGGTGAGGCGGGAGTGAGGACTTGGGGA CTTAAGAACTACCAAAGTTCAGAGTCCAAAGAAACATTAGAAATTGGCTAATCCACCCCC ATAACACGCACATTTTACAGATGAGAAGACTGAGCTCAGAGCATAGAAATAGCTTGCCCA GGCCATGACTAAGTCAGGATAAGGAGCTGGAGCTTGTTTCCTCACTCAGTGGTCCTGACT TTGCACCACTCTGCATTTGCCTAGCCTGCCTTCCTCTAACTGTGCTCTCCCTACTTCCAG GCCTCACCTGCAGATGCCCCCCAGCCTGGGCCAGATGAGCCTGCCCTTTGACCAGCCTCA CCCCCAGTGAGTGACAAAGCCCCTCCTGACCCCATGTGCCTCTTCTTTCCTGGCCTTGCC CCGCTCTCCTTATTTCCATTGCTGGTTCCTGGCAGGGGCCTGCTGCCGTGCCAGCCTCAG GAGCATGCTGTGTCCAGCCCTGACCCCCTGCTCTGCTCAGATGTGACCATGGTGGAAGAC AGCTGCCTGAGCCAGCCAGTGACAGCGTTTCCTCAGGGCACTTGGTGAGTGGCAGCTTGG GAGTGGAGGCTGGGTGGCATCTAGGGGAGTGGGCGCCATGCCTACTCCACTGCTTCTCCC ATCTCCTTGCAGGATTGGTGAAGACATATTCCCTCCTCTGCTGCCTCCCACTGAACAGGA CCTCACTAAGCTTCTCCTGGAGGGGCAAGGGGAGTCGGGGGGAGGGTCCTTGGGGGCACA GCCCCTCCTGCAGCCCTCCCACTATGGGCAATCTGGGATCTCAATGTCCCACATGGACCT AAGGGCCAACCCCAGTTGGTGATCCCAGCTGGAGGGAGAACCCAAAGAGACAGCTCTTCT ACTACCCCCACAGACCTGCTCTGGACACTTGCTCATGCCCTGCCAAGCAGCAGATGGGGA GGGTGCCCTCCTATCCCCACCTACTCCTGGGTCAGGAGGAAAAGACTAACAGGAGAATGC ACAGTGGGTGGAGCCAATCCACTCCTTCCTTTCTATCATTCCCCTGCCCACCTCCTTCCA GCACTGACTGGAAGGGAAGTTCAGGCTCTGAGACACACCCCAACATGCCTGCACCTGCAG CGCGCACACGCACGCACACACACATACAGAGCTCTCTGAGGGTGATGGGGCTGAGCAGGA GGGGGGCTGGGTAAGAGCACAGGTTAGGGCATGGAAGGCTTCTCCGCCCATTCTGACCCA GGGCCTAGGACGGATAGGCAGGAACATACAGACACATTTACACTAGAGGCCAGGGATAGA GGATATTGGGTCTCAGCCCTAGGGGAATGGGAAGCAGCTCAAGGGACCCTGGGTGGGAGC ATAGGAGGGGTCTGGACATGTGGTTACTAGTACAGGTTTTGCCCTGATTAAAAAATCTCC CAAAGCCCCAAATTCCTGTTAGCCAGGTGGAGGCTTCTGATACGTGTATGAGACTATGCA AAAGTACAAGGGCTGAGATTCTTCGTGTATAGCTGTGTGAACGTGTATGTACCTAGGATA TGTTAAATGTATAGCTGGCACCTTAGTTGCATGACCACATAGAACATGTGTCTATCTGCT TTTGCCTACGTGACAACACAAATTTGGGAGGGTGAGACACTGCACAGAAGACAGCAGCAA GTGTGCTGGCCTCTCTGACATATGCTAACCCCCAAATACTCTGAATTTGGAGTCTGACTG TGCCCAAGTGGGTCCAAGTGGCTGTGACATCTACGTATGGCTCCACACCTCCAATGCTGC CTGGGAGCCAGGGTGAGAGTCTGGGTCCAGGCCTGGCCATGTGGCCCTCCAGTGTATGAG AGGGCCCTGCCTGCTGCATCTTTTCTGTTGCCCCATCCACCGCCAGCTTCCCTTCACTCC CCTATCCCATTCTCCCTCTCAAGGCAGGGGTCATAGATCCTAAGCCATAAAATAAATTTT ATTCCAAAATAACAAAATAAATAATCTACTGTACACAATCTGAAAAGAAA OMIM ID 601512