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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for STIM1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID6786
Official gene symbolSTIM1
Full namestromal interaction molecule 1
Aliases,D11S4896E,GOK,
Gene summaryThis gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene.
LocationChromosome: 11   Locus: 11p15.5
Gene position3876933 - 4114440  Map Viewer
Gene orientationplus
Gene size237508 bp
Gene sequence
OMIM ID605921