Entrez gene ID | | 6885 |
Official gene symbol | | MAP3K7 |
Full name | | mitogen-activated protein kinase kinase kinase 7 |
Aliases | | ,MEKK7,TAK1,TGF1a, |
Gene summary | | The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq] |
Location | | Chromosome: 6 Locus: 6q16.1-q16.3 |
Gene position | | 91296907 - 91225353 Map Viewer |
Gene orientation | | minus |
Gene size | | 71555 bp |
Gene sequence |
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OMIM ID | | 602614 |
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