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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for MAP3K7 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID6885
Official gene symbolMAP3K7
Full namemitogen-activated protein kinase kinase kinase 7
Aliases,MEKK7,TAK1,TGF1a,
Gene summaryThe protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]
LocationChromosome: 6   Locus: 6q16.1-q16.3
Gene position91296907 - 91225353  Map Viewer
Gene orientationminus
Gene size71555 bp
Gene sequence
OMIM ID602614