Entrez gene ID | | 6921 |
Official gene symbol | | TCEB1 |
Full name | | transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) |
Aliases | | ,SIII, |
Gene summary | | This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. [provided by RefSeq] |
Location | | Chromosome: 8 Locus: 8q21.11 |
Gene position | | 74884346 - 74858634 Map Viewer |
Gene orientation | | minus |
Gene size | | 25713 bp |
Gene sequence |
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OMIM ID | | 600788 |
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