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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for TEK (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID7010
Official gene symbolTEK
Full nameTEK tyrosine kinase, endothelial
Aliases,CD202B,TIE-2,TIE2,VMCM,VMCM1,
Gene summaryThe TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase. [provided by RefSeq]
LocationChromosome: 9   Locus: 9p21
Gene position27109147 - 27230172  Map Viewer
Gene orientationplus
Gene size121026 bp
Gene sequence
OMIM ID600221