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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for LEFTY2 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 7044 Official gene symbol LEFTY2 Full name left-right determination factor 2 Aliases ,EBAF,LEFTA,LEFTYA,MGC46222,TGFB4, Gene summary This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq] Location Chromosome: 1   Locus: 1q42.1 Gene position 226129083 - 226124298  Map Viewer Gene orientation minus Gene size 4786 bp Gene sequence >LEFTY2:complement(19642077..19646862):Length=4786 GTCCTTTCTAGACAGCCCCCTCCTCCAGGCTCAGGGACCTGTCTGGCTGTGAGCTCCCAG GAGGTCCCAGGGGTGTGACCTCCCTCCCTCCCTCCCTCCCTCTTCCCTTCACCCCAGGCC AGCCCAGGGCCAGCTATAAAGCTGGCCCAGCCTGGCTCTCAGCACACCCAGCTGCCTGAG ACCCTCCTTCAACCTCCCTAGAGGACAGCCCCACTCTGCCTCCTGCTCCCCCAGGGCAGC ACCATGTGGCCCCTGTGGCTCTGCTGGGCACTCTGGGTGCTGCCCCTGGCTGGCCCCGGG GCGGCCCTGACCGAGGAGCAGCTCCTGGGCAGCCTGCTGCGGCAGCTGCAGCTCAGCGAG GTGCCCGTACTGGACAGGGCCGACATGGAGAAGCTGGTCATCCCCGCCCACGTGAGGGCC CAGTATGTAGTCCTGCTGCGGCGCAGCCACGGGGACCGCTCCCGCGGAAAGAGGTTCAGC CAGAGCTTCCGAGGTGAGACCCTCCCTCCCTGCTGGCCCCGGTCCCATGGTCGGGGGCAG GCCGGTTGTGCCCACTCTGGAGGTGTCGAAGGGCCCCTGGCCTTTTGGGACTCTGTGGGA GGCTGTGTGAGGGCCACGGTCCAAGGAGCAGTGAGGAGGAGCCGGGCCTGGGTCCAGGGT CTCCAGCTGTGCACTGAGGCCCCCCTCCAGCCCAGGGGAGGTGCACCAGGCTAGACCTGC TGGAAAAACCAAGACTTCAGAGAAGGGGAGGGTAGAGGAGAGAAAGTAGAGCTGGGGGAG CAGGTGAGTGTGTGCCTCAAGGCACTTGGTGCAGCTGGACTCCCAGGGTATGTTTTCACA CTGCCACTCTGGTCTGAGCCTGACCTTGAGTAAATGGCTTTAAAATCCTCTCTCCACCAT GTGCTCATCTGGAACAGGGGTATGACTATGTCTTCGCCATCTCCCAGCACTGTGAACGTC AAAGTGAGTCCTTGTGGATAGAAGCGTGTTTGGATAACTGAAAAATACCTAAGTAGACTA CCTGGGTTATACCTGGCTGTCAGGGGTGCAACTGGGCCTGAATCCTCCTGCAGCCTCTCG CCTCCCTAGCTCCTCAGTGCCCAGAGCTAGAGCCAGTGCCAGGCACCTGGGTGAGGATTC TGCTCCCAGCATCTCAGCTGAGGCAAACTTGCTAGCCAGGGTCCCACAGGCCCCCCTGCC TGCTGGATGGAAATTGTTACTAAACAAGGCCCAGATCCAAGGAAGATTTGTAAACTGGGT TTGCCCCAGAGATAGAACAGGGCCGGTGTCTCCTGGCCTGGCTGCCAGCTCAGTGGCCCT GCCATCCTCAGAGCTCCGCTGGAGTCCGGGGAGGCCCTGCTGACCCTGCTCTTGTCCCCA GAGGTGGCCGGCAGGTTCCTGGCGTCGGAGGCCAGCACACACCTGCTGGTGTTCGGCATG GAGCAGCGGCTGCCGCCCAACAGCGAGCTGGTGCAGGCCGTGCTGCGGCTCTTCCAGGAG CCGGTCCCCAAGGCCGCGCTGCACAGGCACGGGCGGCTGTCCCCGCGCAGCGCCCAGGCC CGGGTGACCGTCGAGTGGCTGCGCGTCCGCGACGACGGCTCCAACCGCACCTCCCTCATC GACTCCAGGTGGGGGTCGCGCGGGCGCGCAGGGCAGGAGTAGGAGGCTGCTCGGCCCGGC TTGGGGGCGGGGACGCAGGGGGCGGTGCAGGGTCCTCGGGGCCCGTCCCAGTCCCCGCCC TCAAGCGGCGCTGGGTCTCCGTGTCGTGTGTATCATGTCTCAGGCTGGTGTCCGTCCACG AGAGCGGCTGGAAGGCCTTCGACGTGACCGAGGCCGTGAACTTCTGGCAGCAGCTGAGCC GGCCCCGGCAGCCGCTGCTGCTACAGGTGTCGGTGCAGAGGGAGCATCTGGGCCCGCTGG CGTCCGGCGCCCACAAGCTGGTCCGCTTTGCCTCGCAGGGGGCGCCAGCCGGGCTTGGGG AGCCCCAGCTGGAGCTGCACACCCTGGACCTCAGGGACTATGGGTAGGTGCAGGACTGGG CAGAAGGGAGGCAAGCAGCCACTGAGTGGTCCAGACCCCCGTCCCCAGGACTGTCTGGGG GACCGGATGGTGGCGGTGGGCTAGGGGTAGGGAGAGCGCGGTGCAGACTGTCCCAGGATG CCAGCGATTGCCCACTACATGTCAGGGTTTCTAATGGCAGAAATTGTATTGTTGGCCAGG CGTGGTGGCTCAGACCTGTAATCCTAGCACTTTGGGAGGCCGAGGCGGGCTGGATCACAA GATCAGGAGTTTGAGACCAGCCTGACCAACATGATGAAACCCCGTGTCTACCAAAAATAC AAAAATTAGCCGGGCGTGGTGGCGCGTGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGC AGGAGAATCACTTGAATCCGGGAGGTGAAGGTTGCAGTGAGCTGAGATCACACCACTGCA CTCCATCCAGCCTGGAGGACAGAGCGTGATTCTGTCTCAAAAAAAAAAAAAAAAAAAGGA AACAAAGAAAAGAAAAGAAAAAGAAATATTATATTATTCAGGCCAGGCGCAGTGGCTCAT GCCTGTAATCCCAACACTTTGGGAAGCTGAGGTGGAGGATTGCTTAAAGCCAGGAGTTTG ACACCAGCCTCGGCCACACAGTGAAATCCTATCCTTAAAAAAATAAATAAAAAAAAAAAG TTTTAAAGAAACGACAAAAAAAAAATTGTAAGGCCAAGTATGGTGGCTCACGCCTGTAAT CCCAGCACTTTGGGAGTGGAGGCCAGCGGGTCACCTGAGGTCAGGAATTCCAGACCAGCC TGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATATAAAAATTAGCTGGGCGTGGTGG CGGGCGCCTGTAATCCCAGCTACTTGGGAGGCTGTGGCAGGAGAATTGTATGATTTATTT TATTTAAAAATATCTTTGACAATCTTCAATGGATTTTTCTATTGCCATTGACTCCATATA CACGATTGTAATCATCTACTTTCACTTTACCCTTCTCCATGATTAAATCTTTGAAAAATC CTAGCTTTAGCTGTTACTAGGGGCGATGAGCTTTCCTCCTGCTTTGGTGAATTCTTTCTC ATGGACAAGTTAGCTCTCTGGAGCAGATGGGGGCTGTGTAGCACAGTGGTTAAGAAGAGG CCTTGGAGCCGGTTGGCCTGGGCTCCATCTAGCTCTGCCTTCCACTGGCTGTAGGTCCTC TGGCCCATCACCGAACACCTCTGGGTGTCAGTGGCCTCAGGTGGAATGGGGATAATGCTG GAACCTACCTGAGGATGAAATGCAGACATCACCTGAGATAATACATGTGAAGTACCTAGT TCATTGTCTGGCCTATTAGGAGACCTTTAATTAATAGTAGCTGATTTATTATTTATGTTT CAGATATGTTTATTCATCTTCTCACAAATATCCAGCTTTTAGAACATAGTGAGAGCTGGA TCATAAACCTCCCTCCCAGGTGCCCACTAAGCTGTGCCCCAGGCCTTCTGACTTCAGCCT CCCAGATGACCTCTGACCCTGCTCTCCTTGCCCACACAGAGCTCAGGGCGACTGTGACCC TGAAGCACCAATGACCGAGGGCACCCGCTGCTGCCGCCAGGAGATGTACATTGACCTGCA GGGGATGAAGTGGGCCAAGAACTGGGTGCTGGAGCCCCCGGGCTTCCTGGCTTACGAGTG TGTGGGCACCTGCCAGCAGCCCCCGGAGGCCCTGGCCTTCAATTGGCCATTTCTGGGGCC GCGACAGTGTATCGCCTCGGAGACTGCCTCGCTGCCCATGATCGTCAGCATCAAGGAGGG AGGCAGGACCAGGCCCCAGGTGGTCAGCCTGCCCAACATGAGGGTGCAGAAGTGCAGCTG TGCCTCGGATGGGGCGCTCGTGCCAAGGAGGCTCCAGCCATAGGCGCCTGGTGTATCCAT TGAGCCCTCTAACTGAACGTGTGCATAGAGGTGGTCTTAATGTAGGTCTTAACTTTATAC TTAGCAAGTTACTCCATCCCAATTTAGTGCTCCTGTGTGACCTTCGCCCTGTGTCCTTCC ATTTCCTGTCTTTCCCGTCCATCACCCATCCTAAGCACTTACGTGAGTAAATAATGCAGC TCAGATGCTGAGCTCTAGTAGGAAATGCTGGCATGCTGATTACAAGATACAGCTGAGCAA TGCACACATTTTCAGCTGGGAGTTTCTGTTCTCTGGCAAATTCTTCACTGAGTCTGGAAC AATAATACCCTATGATTAGAACTGGGGAAACAGAACTGAATTGCTGTGTTATATGAGGAA TTAAAACCTTCAAATCTCTATTTCCCCCAAATACTGACCCATTCTGGACTTTTGTAAACA TACCTAGGCCCCTGTTCCCCTGAGAGGGTGCTAAGAGGAAGGATGAAGGGCTTCAGGCTG GGGGCAGTGGACAGGGAATTGGGATACCTGGATTCTGGTTCTGACAGGGCCACAAGCTAG GATCTCTAACAAACGCAGAAGGCTTTGGCTCGTCATTTCCTCTTAAAAAGGAGGAGCTGG GCTTCAGCTCTAAGAACTTCATTGCCCTGGGGATCAGACAGCCCCTACCTACCCCTGCCC ACTCCTCTGGAGACTGAGCCTTGCCCGTGCATATTTAGGTCATTTCCCACACTGTCTTAG AGAACTTGTCACCAGAAACCACATGTATTTGCATGTTTTTTGTTAATTTAGCTAAAGCAA TTGAATGTAGATACTCAGAAGAAATAAAAAATGATGTTTCACTCTG OMIM ID 601877