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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for THRB (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID7068
Official gene symbolTHRB
Full namethyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
Aliases,ERBA-BETA,ERBA2,GRTH,MGC126109,MGC126110,NR1A2,PRTH,THR1,THRB1,THRB2,
Gene summaryThe protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq]
LocationChromosome: 3   Locus: 3p24.2
Gene position24536313 - 24158644  Map Viewer
Gene orientationminus
Gene size377670 bp
Gene sequence
OMIM ID190160