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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for TLR4 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID7099
Official gene symbolTLR4
Full nametoll-like receptor 4
Aliases,ARMD10,CD284,TOLL,hToll,
Gene summaryThe protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Also, several transcript variants of this gene have been found, but the protein coding potential of most of them is uncertain. [provided by RefSeq]
LocationChromosome: 9   Locus: 9q32-q33
Gene position120466460 - 120479768  Map Viewer
Gene orientationplus
Gene size13309 bp
Gene sequence
OMIM ID603030