Entrez gene ID | | 7100 |
Official gene symbol | | TLR5 |
Full name | | toll-like receptor 5 |
Aliases | | ,FLJ10052,MGC126430,MGC126431,SLEB1,TIL3, |
Gene summary | | This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease. |
Location | | Chromosome: 1 Locus: 1q41-q42 |
Gene position | | 223316624 - 223282748 Map Viewer |
Gene orientation | | minus |
Gene size | | 33877 bp |
Gene sequence |
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OMIM ID | | 603031 |
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