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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for TMPRSS2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID7113
Official gene symbolTMPRSS2
Full nametransmembrane protease, serine 2
Aliases,FLJ41954,PP9284,PRSS10,
Gene summaryThis gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
LocationChromosome: 21   Locus: 21q22.3
Gene position42880085 - 42836478  Map Viewer
Gene orientationminus
Gene size43608 bp
Gene sequence
OMIM ID602060