| Entrez gene ID | | 7133 |
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| Official gene symbol | | TNFRSF1B |
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| Full name | | tumor necrosis factor receptor superfamily, member 1B |
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| Aliases | | ,CD120b,TBPII,TNF-R-II,TNF-R75,TNFBR,TNFR1B,TNFR2,TNFR80,p75,p75TNFR, |
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| Gene summary | | The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq] |
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| Location | | Chromosome: 1 Locus: 1p36.3-p36.2 |
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| Gene position | | 12227060 - 12269277 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 42218 bp |
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| Gene sequence |
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| OMIM ID | | 191191 |
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