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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for TNNT3 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 7140 Official gene symbol TNNT3 Full name troponin T type 3 (skeletal, fast) Aliases ,DKFZp779M2348,TNTF, Gene summary The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein; also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B). [provided by RefSeq] Location Chromosome: 11   Locus: 11p15.5 Gene position 1940799 - 1959936  Map Viewer Gene orientation plus Gene size 19138 bp Gene sequence >TNNT3:1880799..1899936:Length=19138 ACTTGGTAAGGGGCCTGCACGGGCATAGCCCCCCCCAGCAAGACTCCGCACACACCCCGG CCACCCAGTCACTGGCCAATGGGCTCCTAGGAAGATCAAATGTCACTATAACACGAGGGT GTGAGCCGGGCGCCAGTGCCTGCAGCCGGTGCTGTCCACAGGGAGCTCCAGCCCTTCTCA CACTCGACCCGCAGGTGGGTATAGGCAGGAGCGGCCACCCAGGACTGGGGCCGACGGGGC CTCCTGCGTGCGGGTGGACAGCCCCTCGTTCCAGGGACACTCTGGGGTCCTGGGGCGCTG AGGTCCCAGGTCCGTGTGGTGCCGAGCATCTCGAAGCATCATGGCTCGGAGCCCCCAGGT GGCTGCTCCAGCGTCCGGAGAGTCTGGGATGCGGACATGGTGGTGTGATGGTCTCAGCAC CGGGAGGATGCAGAAGAAGGCAGAGTGTGGGAGGCCAGGAGGGGGCAAGTCGGGGCTCAG GGAAGCTCAGTGCTAGGGAGTGGCCTGAGGGCAGGAGGCAGAGAGGTGCGGGCTGTGAGC GGCAGGGAAGAGGCTGTGCAGGGGTGCTGCCAGGGCTTAGGTTGCCAGCTTGTGGTCGCC ATGCAGACATTTGCCCAGGCCCGTCCTGGCCTTGCCATGCAGCTCTCGCACCTGGGCCTC CAACACCGCCATTTTGTAGAGATGAAAACGAGGACAGGAGGGCAGGGGCTCCTGTATGGC CAGCCCGAGTGTGTTGGGGTGGGGGCGTCTAAAGCCCACGCAGCCTTGGGGGCCAGCGTC TGGAGGTGCAGGACAGAAGTGGACAGGGGCTGGACTGGGGCAGGACGGGGCAAGAGTGAG GGGCTGGGCTTCATCGCGTCCCCCTGGCTGGAGGCTGGAGAAGCTGGCGCTCGTAAGAGC CCCCACCCACCCTCCCTGCCCTGGACACGGTCCCCCTGACTTGTGCCGTCTGATCAGGCC TTGGCTGCCCCTCCTGAAGTCCACGGAGGGACATGGGGCAAAGCAAAGGTTGGCTGGGTG GAGAACAGGTCTGGGGGCATGGTCAGGGCCACAGCAAGCAAGGGGCAGCGGCTTTTGCCT CCCCACCCTGCCCTGGCCCCGTCACCTCCCAAGGAGGGAAAGGTGATGCATACGTGCCCG AAGAAACTGACCGCATAGGTTATTTTCACGCAGCCCCTCCAAGGCAGGCACTAACTGGAC ACCTGCTTTGCGTCTCAGCTGTTGAAATGCCATCCCCTGCCCCCAGCACACCCCTGCCCC CAGCACACCCCTGCCACCAGCCCCTCCCCGCAACAGAGGCAATGACACAGGCCATACTGG GGGGAACAGAACAGCCTTGTGTTGCTTCCAGGCGCTCAGCAGAAAACCAGGTGCCTCAGT TTCCCCACTTGGAGAGTGGGCCTTTCCAGCGCACGTCGGGGGGCCTGGAGGTCACCCTGC CTGAGGGTGTTGGGGCACCCATGTGACTCTGGCCTGGGGGGACAGGAGGGAAATATGAGG AGCTGGGGAGGGCCTGGGTGCCCGAGGGTGAGGGGGCAGCTGTGGGCCAAGGAGGGCTGG GCTGTCACACCCGCCTCACCCACGTCTTGGGTTTCTGGGCAGAAACGTCTTGCCTATTTC TGGACACCTCAGCTGCCACTGGCTCCTTATAAATAACCCACCCCAGGCGAGGGCCACGCT GCCCCCATCTTGTGGCAGCCGACAGGTGTCTGCCCCGCCAGCGTCGGGCTGGGCACAGCA GGGCGGGGCCAGGCTCCGCTCCCTCCCTTCACTGACCCTCCTCCTCCTTACAGAGGATGG CCCTAGAGGAGTCTGTGGCGTTTGGGGCCTGAACCAGCTGGGAGGACAGCACGAGGGGCT GGTGGGCAGCCTGGGACTGGGTCACACCGGGGGCCTGGACAACACTGGCTCGTGGGGCTG AGGACTGAGGAGAGCCTGGCCCAGCCGTGGCAGTTACAAGAGGCTTAACCTGAGGGGCAG CAGAGTCTCAGGAAGAGATTCTGGGATAGGAAAAAGCTACCCCCGTTGCCTGGAAGACAG CTATCTGCTGGGTAATTTTGCATGGAGCTTAAGTTGCTCTGGGAAAATTAACATTCTTGA CAGAGGGTTTGGAAAACGGTTCCCACCTCAGCAGTGCAACGTAGATGCATTTTTAGCTGA TGAACGTGTGTTTTCCTTATACAACACTCCCAGGGGGGACCGTAGCTATTGTCTTCGAGT AATCTGTACTGTGTTGTAATGAACTTTGTTTTCTAAAACCCTGGCCAACATGCCGGTGCA GCTGCTCAGAGCCTCCCCAGGCCTGGCCGCCCAGTGTGCACGGTGGCCAGCTCACAGAGA GACGGTCCCCAGCATGCTGGCCTGGCGCCACCACCGCACATGGACAGGGCAGCCAGTCCT GGGCATGGAGCTTCCCCTAGACAGGGACAGATCCAGAGCATCCCCGGGACCAGGGAAAGC GGCCACAGGGAGGGAAATGGGGGGGCTGTTCTGTGGGCTCCTGCAGTCCAAGTATGCCTT GTACAGAGCCCGGCCCGGGGGGGTGCACGGGAAGCGGCCCAGACCCAACCCAACGTGCTC TGGGGCTCAGCCTCAATGTTTTCAGGGTACAGGGGTAACAAGAAGGAACAGCTTCCCTGC TCTGTGATCTTGGAGGAGGGGTCCTCAGAGGGGTGTGGTGGGACACACTCTGGGCACCCC ATAGGAAAACAGGCACAGAAGGGAGCTTTGGGCTCAAATAGGGAAGAGGGGTTCTCATGG GGAATGGTAGGGTGAGCAGATTACTCATCTTGGGGAGCCAGTCTCGGTCATCCAGGGGCT CCCAGGGAGACCCCACCTACACCCACTGGGCAGAGAACACCCAGAGACAGGTTTCAGCTC CATCAGCGGGACCTTTCCAGTGTCTAGAGCGGGCTGGACGGCACACGGCCTGCATTCTGG ATGACCCTCCTCAGGGGACGCCACGGAGAGGATGTCTGCCCTGGGTGGGGGTGGACGCCA CGACCTTCCAACATCCCTTCCAGCTCCAAGATTCCAAGCTCCAGTCTGGAGCCAGGGCAG GAAGAGGGGACAGAGTCTGGGGCGCCAAGAGCTGGGAGGGGCCAGGAGCCCTGGAGAAAG GGGAGGCCCAAGGAGGTGGACTCACCCAAGGCCAGAGCTGGCCCCCAAACCCTGCCCGCG GTCCCCCACAGCGCTGCTCCAAGACCCCATCCCCCATCCTACACCCAGGCAGCTCGTAAC TCTCTTTCCATCCTCTCTCTCTCTCTCTCTCTGAATCTCTCTCTGCAGAAACCACCCACC TTCACCATGTCTGACGAGGAAGTGTGAGTACCCAGCTGGTGGCTGCCCCCTGCCTGGCTC GGGACCCTGGCCCCTTGGCTTCTGTGGGGCTGGAGCATGCGCTATCTTGCACAAGTCCAA GCAAAGCCCAGCCTCACTACCTCTCTCTCTTTCTTTCTCTCTCTCTCCCTGCCCCACAGT GAACAGGTGGAGGGTAAGTGTAACAGCCATTTTCTTTCTACTTCCTGCTCTAGAAGGAAG GCTCACATGTGGGCAGGGGGCTGGACTGTGCATACCCTGTGTCCCCTTGACAGCCCTACA TCAGCTGCATCCCATGGGTGGCTTCTGAGTGACCCCCGGAAAACAGCTGTCCAAGTGGGG GGCCTCGTCTTTTCCCCGAAGTGTGGCCACATGGTCCTGAGGGGCCTGCAGGTCAGGCTC TGGGTCCTGTCTCTCTGCTTCTCTCATGCCCACTGTGGGACGTGGGCATCCAGGACCCCC GAGCCCCCCAAAAGCCACCATCATCACCAGAGCCTCTGCCTTCCCCAGCGCCTCCTCAGG GCCCGAGGACCCCTGATTCCACGCTCTTGGGCAGGGGCAGTCGCTGGCCTGTCCAGGGCC GGGACACACTGGCCTCTCATCCTCCTCCTCCCTTCACGGGCTGCCCCTTCTAACGTGGTT CCCCTCTTTGTTCTGTCCCAATGCAGAGCAGTACGAAGAAGAAGGTAATTCTGGCAACCA CCGGAAGCCCCCCCAGCCCCTCCTTGGAACTTAACCCCCCTCTCCCGTGTGGCGCTCACA GAACCCCCTCCCCAGGCTGCTCCAGGCCGCCTTGAGCTTGTCAATCAACCTTCCATCTTC CTCATCATTAGTCACTAACAATCACCATTCATCATTAATTAATGATAAATGAGGCCACCA CTTAATTAATGATGGATGAGTCATTAAATCATCACTAACCCCTGTCTCTTTAATCGATTA ATATGCATTCACGATCCTTCATTAATCCTTCATCCTCCGTGTGCCATGGTGTGTGGAGTT CACTGGGGCTGGTCATGAAGGCCTCAAAACACCGAGTGCCCTGCGTGCCCAGTGCTGCTG TCTCTCTGCCTCTCTCTCTATCTCTACCCTCCCGGCATCTCAGAGTCTCTCCATCTCTCT CCAGTTCCTTTCCGTGTCTCTCTTGGCAACTTTGTCTCTCTGTGTGCCTGTGTATCTCTC AGCTTCTCTCTGTCTCTGTATCTTTCAGCCTCTTGGTCTCTGTCTCTCCCTGCCTCTCTC TCTCAGTCTCTGTCTTTCTTGGCCTCTCTGTCCCCATTTCTCCACCTCCATCTCCATCTC TGTCTCTCTGTGTCTCCATCCCTCCATGCCACCCCCCAACCCTGTGCTGTAACCCTGGGT GGAGCCTGGAGCCCCCTCCCTGTGCTGGCCAGGTGTGGTCTGTGGGCGTCTCCATCGTGC CCGGGCAGGCGTGGGCGGGTGTGGGCGCACCTGGGAACCGTGTGGGGTGGCGGTTCTCAG GCCGACGGCGCTGCCCTGGAATCCCTGGCACCCACTCAACTGGGGAGCGCGTTCACGCAA CCTTAGCAGGCAGGGCTGTCCTGTGAGGAGTCCTGAGTGCTATGTTTTGAAAATATTTTG AAAACACTTGGCTACCCTAACAACGTGAGCAAAACATTTATTTTTCTGCCGAAAAGGTGG AAAGACTCATTTCTGCGAGGGAAATATGGCACTGGGGAGCCATCTTTTCTCTTGGGGCAG CCACGTGGCAGGCCGGGAGGCCACGGAAGGGTCTTCGTGCGACATGTCTCTGAAGACCCC TCAGTGCCAGCCTTGTTTCCGGGTGCACTCAGAGCCGGGGCTTCCCGCAGGCCCTGTGGG TTCTGTCCCCGTTCTCACTTGTGTCACCTGCAGAGCAGGACTTAACAAGGGCCCCCGTGC ACAGGCGCCTCCAGGCATGGGAATACCAGGCCCCCAGGAGGGTGGGAGGGGCCTCAGAAC CCCTCTCAGGGGCCGGGCCCAGCCCAGCTGACAGTGACCAGCTCTGCTGGTGGGAGTCCG TGCTCCCCGGGGCTGGCCAGAGATGCAGGACTGAGCCCCATCTTTCACCCCTGCCAAGCG AGCCCCAGGCCCTCTTCTCCCGGCCAGCCGGCCTCCTGTCCTTGCGGCCTGAGTACACTC TGATCACTGTCTCTGTTCCCTGTCTCCCTCAACCCCGCCTTCTCCTGCTCCTGGCTTCTC CGGCTCTCAGAGGAAGCCCAGGAGGAAGGTAAGTGGGGTCCAAGGCCCCGGCCCCCATGC CCACTCCCCAGCCTTCCCGCCCCACCCAAAGTTGACCTCCACCCCGCCTCTAAGGATTGC TGTGTGCCCCTGTCTAACCCTCTCCTCTCTCCCCCGGCTCTCCTCAGCTGCAGAAGTCCA TGAGGAAGGTATGAGGACACAGGACTTCTTGTCCCCATGTGGGGCCCGGGGCCTGGCTGG AGCCCATGTGGGGGTGGGGGAGAGGGGGAGAGGGTGGGGAAGCCACGAGGTACCAGCCAG CCAAGGGGCCCCCACATGTGGCCCTAATGTAACCCACTAACCGCGGCCAATGCTTGACCA GAGAGAGAATGGGGTCTCGAGGGTGGGCCCCCTTCCCCACAGCCCCCCAGGCAGTAGGGC CAGGGACTCCCCAGGCAGGTGCAGGCTGGGCTGCTGGTCAGCAGGGTGTCCCCAAGCATG GGGCAGAGGGGACACGTAGGCCCACCCTAGTCCTCCACCCCAGGGTAGGCAGTCCAGAGC CCGTGGTGGCGTCGACCCCTGGGCCTGGCCAGGACGCCCGCCACATCTTGGGATGGCACA GAGTGAGGGGAGAGAAGGCGGCTGGGGGCAGAACCCTGCAGCCTGGCACAGTCAGCTCCC TCGTGAGCATGCCCTCGTCAGCCCCCCAGGCCCCCTCACAGCCTTCTGCTATGAGACCCT TGAGGTGCACACAGGCTGGGAGCAGATGGGAGGGCTGGGGTCCCATGCCCAGATCAGCAG GCAGAGCCATCACTGGTGCCCAGGGCTGCCAGCACCCTTGGAGGGTGGAAAGAATTCCAT CAGGGAAAGAACGAGTGGGCCCCCAGCGTTGGGATGGCAGGAAGTGGGGGTCCTGGGGAC GCCTTCCATGGCCCATCCATGGCTCTGCCTCCCAGGGCTACCAGCACTGCCTTTGTGGGC CCTTGGTGCCACCCGGCCAGGCTACAACCTCGCACGTGGGCCTTGGTGCCCCGGCCAGAG GCGCGGACACCCTTCTGGGGGCGCCCCAGGACAGACAGGGGATGGGGGCGAGCAAAGGAA GGCCCAGCCCCAGTACTGAGCCTGCTCCACCAAGGACAAGAGCCACAGCTCCCGGCCATC CTCTGAGCCTCAGTTTCCCCACCTGGGGTGCTCCCAGATGCTGAGAGCAGGGTTTGGGGA CATGGGACTGGGGCGGTGGCCGCGCCTGGGCTAACTCTGACCGTGTCTTGCTCGCTCCCC GCACGCACCCCACCCTCGGCCTCGAGTGGCGACGGGCTTTTCCATTAACCTCGGACGCTT CTCCATTGACCTCTGACCCGCGGTTTTGCCTCTTGTTCCGTGGCCTCCTTGGCCCGTGAA GTTCATGAACCAGGTACGTGCATGACTTCGATGCCACATGGGCACGTGTGGCCATGTGGG GGGTGCAGGACCCAAGAAGGAACAAGAGGGGCCGCGTAACCCTGCACAGCCTGGCCTGCT CGCTCCGCCGCCTCGGCCCTGCCCGCCCTCCTCTCTGCGCTGCCACCACTCACACTGGTC CTCTCTCTCTCCCGCCCTTTCTGCCACCATGACGCTGCTTCTGCAGAGGAAGTTCAAGAA GGTACGCCGGCGCTCCCCCGCCTCCAGGCCAGAGTCTCCGTCCTCCCTTCTGTCCTCTCT TGCTTCCTCCCTCTTGCCCACCCCTTGTGACGTTTGCCACCAACAACTGAACCCGTTCTG GCCTCTGGGCTGGGGACAGAGTGAGGACCCTGGCTTGGGAAGGGCTGGCCGGTACAGTGC AGGCTTCCTCTGTGTCTCCCAGGCAGAGAGGATTGATTCCATAGCCTGGGGACAATGAGG CCCTTCCTGGGCTGCCAACAGGAAGGTGGGAGGTGGGGGTGGCCAGCCTTGAGGCCGAGG CAGAGCAGGCCTTGGGAGGACGGTGCTGGGGTCCACTGGGACCCTCTGGATCCACCAGGG TGGGGTGGGAAGAGCGCAGGAGAGGCCTCCACCCTGCCCCAGTTAGCAAGCCAGAAGCGG GAAGGTAGGGAGGGGTGAGGTGGAAGGGAGGGTGGAGGGGCAAGTGGAGTGAAGCAGAAA AGCAGGCTGAGGCCCAAGGTGGGGACGCTGGGGACCCGGAACAGCCAGGGGCCATGCGTG CAAAGGCCCAGTCAGGTCCCAGCATCCCACCCATTGCCTGGGCCTGAGCCAGACACACCC GGAGTGAGGAGGCCCCCTGGGTGGGCCTGCCCTCCCTGGTAGTGGGGCCGGCTGTACTGG GTGGAGGTCAGAGAGCTGCACATTCAAGTCAGGGGCCCCAGCTGGGGAGTGCTTCTCAGC TCCCCCCGTTCATGGGCCGTGGGGCTGAGGGGCTCCTCCCTGCCGGGCCTGAGCTCTTGC GTGACTCGAGCCTCGGAGAGGCCCCTGGACAAGAAGGGACATGCTGGGAGGGGGATGGGA CTCCAGCCATGCAGGGAGGTGTCCAGGAGATAGCCTGTGGGGATGACAGGGTTGCTGGGC CGCTCTGGAACCAGCACTGAGGCCAGCGGACAGACGGACAGCAGGGCAGGGTGGGGCAGG AGCAGAGGAGGCAGGGCCGCAGGACAGCTTTTGCCGCTTGGCTGTGTGCTCGCTCCCCGA AATTGCTCAGCCTCCCACCCGACCTCGCCCTCCTCCCTGGCCGGCCTTCCCACCCGGAGG GGCTCCTCAGCCACGCACTGCGTCCAGCAAAACCACTAAGTCAGGGAGGCCAGGGCGGGC AGCCCATTCATCGTCCTCACCGCGCTGTTCCTTCCGGGCCCTTGGCTGGAACGCTCAGGA TGCCCCACCGCTCACTCCCGGTGCACATGTGCCCCAAGGCATCCGGAACGGGTGACCTCA GGCCCACCTGCAAAACCAAGAGCGCTGGCGGGCTCTCTGTGGTGTGCAGGGGGCTCCCAG GCAACCGAGGTATCTGCCAGCGAGGAGGACTCAAGGACCAGTGCACCCCAGGCCAGGCAC TGGCAAGGCAGGACCCCCACCCCCGGGCCCAGGCCTGCTGGCCTTAGCCAAGTGCAGGGG ACAGCGCTGGGTCAGACTTGGAGGGCCGAGGGCATCGTGTGTCAACGGCCTTGCTGCCAC CTAAGGCCCAGAGCAGGGACTGAAGGGACAGGATGGGCGGGTGCCACTAGGCCAGCGGCA GACCCCCCTCCTGGGCCCCAGCTGGGCCAGGCCAGCCAGGTCCACCCCAGGGTCTAGGAG CAGAGTGTATCCTAAAGGAAGCCACCCCTTATTAGGGTGGCCAGGGCAGGCCAGGCAGAC CCCAGAGGTGGCCAGGGAGAGGTAGCAGGGGGGTCCCAGAGGGGCCCAGTCTCAGGACAG CAGCCATGTGGCAGTCAGAGGGCAAGCCCCAGGGAGGTCAGGGATGAGTGCGCCTGGGCT CCTGGCCTGTGGGTGGGGGCTGTGGTGGACATTCCGGACTCAGGCGGGGGCTCCTGGGGC TGAGACCAGCAAGGAGTTAGACATCACGTTGCCGGCAGAGGCTCCTGAGGCCTGAGGGCT GTAGTCATTCCATGAACTGCTGGGTTCCACCCAGTAACACAGCCTTTACAGGCAGGGGTC AGGCTCCGGGAAGCACGAAGCAAAGGGGCTGCACCCACCCCGGCTGCAACGCCCTCTTGG TGGAGAGGGTCTCAGATGCCAAGGTTGGCCCTGCCAGACCCAAGAGGACAGACCGGGGGG ACAGATGAGACCCAGTGCCCTTAGCCCCCCACCTTGCCCCGCGAGGTCCCCGTGTCCCTC CTATTCTCCACTAGGTCTTCCAGGCAGGAGCTCCACTGGGCACCCAGCCCCTTCCACCCC CTCCCCAGGCATTGATTCACCGGCCCCAGCTTGGGGCACTTGTAGGGCCCCGCAGGCACA CCCTGGAGAAGAGAGTGTCCGAGTGAGAGGGGTGGGCCCCTTGCCCGCCACAGGCCCCTT GCCCACTGCTCCCCCGCAGCCGCACTGGCTTTTCTCTTGCATGTGTGCTTGTGCCTTTTG CCACCTGGAAGACACCGCAGAGGAGGACGCGGAAGGTAAGGGCCCGTCCCTGCCGCCGGA GGTGCAGGACCCTGGCTCTAGCCGACGCGAGGGAAAGAGGACAGGCTGGGGTCTCTCGCT GCCCTGCCTCCTCCTCCCTCTGTCCTCTTTCTCTTCCCCTGGCACGGGGGCCTCGGAGGG CCAGGCCTTGCTGCTCCGCACGGTGCCGCTGGGGTCGAGCTGCCAGGGCCTCGCGGGTGC CACCGCTCCAAGTTTCTGCCACACAGCGGAGGGGGAGTAAGCGGGACCAGCCAGCAGTGC CAGAGCCCGGGCCGGGCACGCCCCCCTCCCCTTTCTCCCAAGCCCCTTTCCTCCCAATCT TCTTCCCGAGCCCCTGTCCTCTTTGCTCCGTCTCCTCCCTTCCCAGCCTTCAAGGACGCG GCCTGTCTCGCTCCTATTTCTTCCCTACCTCTTCCTCACCCTTCCTCCTGGCCCCAGGCC CTGAGCTCTTCCCCTCCAACCCTGCCAGGGGCTTTTGCAGGCCTAGAGCAGAAACAGGAC CCTCTTGTTTCTGGGGGTTGGGGGTACTCCCAGCTGAAAAGGACGGTGGCCTTCAGTGAA GGGGAACCCAGGGCCGCAGGCCGCCCAGTCTCACCCAGGCTGTCTCTCTCCCTCTCCCCA CGCTGGTGTCCCTCTCCCTACGCTGGTGCTGTGTGGACCAGAGGAGAAACCGAGACCCAA GTGAGTGTGGGGTCCTGGCAGGCCCGCTGCTGAGTGTGTTCTGGGGTGGGGGTGGTCAAG TGAGTGTGGGGTCCTGGCAGGCCCAGTGCCGAGTGTGTTCTGGGGTGGCGGTGGCCAAGT GAGTGTGGGGTCCTGGCAGGCCCAGCGCCTCGTGTGTTCCGTGGTGGAGGCGGAGGAGAG GGCCAGGGCCAGATGCCTGGAGCCTGCATTCGGAGGGACGCTCAGAGCGCAGGGTGGGAG GGATGAGGGTCACCTGGGAGATGGGCTTGGGAGGCCCAGCAGGGTGTGATTTTGCCCAGG GTCATCCAGTGCAGACAAGGAGGGCTTCCTGTAGGAGGAGGCTGCAGACGAGGAAGGAGG GAGGAGAGGTGGGTGGGAGAGAGTTGAGGAAGGAAGGCGGGGCAGCTGGTGCAGGGAGTT TGGCCACCGCAACACCCCACGGCCTTCGGGGGACCACACCAAGCCCCGCCATACTTCTAG GACTCCCAGAGTCCTAGATTGAAAAGCGACAGGAAAGTGAGTCCGGAAGTGGAGAAAGGT GGGGGACTCAGCCCAGAAACCCACTTCAGAATGACACCTTGACCGTGTCCAGAAGAGCTC ACTGTGCAGGGGCCCCTGCTCCCCTTTGGGGCAGAATTCAGAGGAGCTTGTCCTCATCGC ACCTGCTTGTGAGCACTTCGTGGGTTGGTTTTTTTAATGCAGCTCTTCTGACTTTTCTGC TTTTGATCGGTATTCACCAGCCACAGCACTCGCTACGTGATTCACCCTTTTATCTCTCGA GTGCTCTTGCCTGTGTGTTGCTCTGTGCGAAGTGGAATCTTAGAGCATCTTGACACACAC TCACTGTTGGCTCCCACTTGGGGAGCATTGCAGATTCTCAGAAGAGTGAGAACATCTGAA GGGTACAGCCGGCGTATTCCCACCCTTTGCACTGTATTTTTCAGTGATTTTAAGTACAGT AATGCTGGATCATGAGATATTTTCTCATTTTAGAAAAATTGTTTGTGTTTTCATTATGAA AATAAGACACCTCATGAAAGAAAATTTGGAAAATATATAAAAGTCAAATGAAGAAAAAAC GTCATCTATAATTCTCCCACCCAGCCAGCCAGACTGTGGAAAAGAGCAGAAAGAAATAAA AAGCCTTATTTCTTCCTTTTTTCCATGCATAGCGCTTGGAAAAAAAAGATTTAAAGTCGG CCTTGTTTTTCAAACATCATACCGTCTCTACGGCCTTGAATTCTGCTTTTTTTAAAATTT AGCACTATTCATAAGTATTTTTCCATGTTTTTACACAGTCTTCTTAAATATTTTGAATGG CCACATAATATTCCATCAATTGGACAAACCATAATTTTCCTAACCATTCCCCTATTGCAG GCTTTCCCCAATATTTTACTATCATAAATAACGCTGGTTGGAAAGCGTTTTCCATCTTTA GGGTTATTTCCGTAGGCCACATTCCCAGAACTGGAATTACTGGGTCAAAGAGTATGAATG TTCTTAAGGCTTTGACATCCACTGCCAAATTGCTTTCCACAAGGGCCTGGCCAACGCCGT CTCCTACGTGGGATGTGAGCGGGTCTGTGTCCCACACCCTCCTCACCCAGGGACAGGAAC GTGCTTTTACATTGCAGCCTCTGATGGATGAGAAACGGCACCTCATGATTCTTTGGCTTT GCGCCCTAACAGTCACTCGGGGCCAGCGTTTCCCTGAGTTTGGGATGGGTCGTCTCTTCT CTGAGAACTCGTAGCTACGGCCATTGCTCATTTGTCTCCTGGTGGAGGAATCTCTGTGTT TTCTTAGTCATCAGTTTGCATAAGGATATAAGTCTTCTCTGTATTTGCTGAAAATTTTTT TTAGTCTTTTTTTTTTGCCTTTCCATTTTCCGTTTTTTTTTTTTTTTTCACATACATACG TTTTTCATTTGCGTGGTGTCATCTGGCCTTCTTTCCCTTAGAGGCACCTTCTGGTGCTCC TGAGCTTAGGAAACCCTTTCCTGCTCCAGTTTCTGATTGATATTTAGTTCCACTTTCTTC TATGGTTTGTTGGAAAAAATTGTTGTTGTTTTAACTCTTTGCTGCATCTGGAATGTATTG GTGAGAGGAGGGGACTGCACACCCAGCCGGAGAGGGGGCCTCATTTCCCCTTCAGATTGC TTTCTTCCCAGCCCCCTCTCCTCCTTCCTTTGGGCCCCCAGAGAGAAAGATGAAAGAGGG GCTGGGGAAAGGCACAGGCTCGCAGCAGCCATTCCTGCCCAGGGAGGCCACCGCCACCCA CAGTGGCCATCGCTTCTCACCCGACATGGCTGCATTTGTTTATCTGTTTGAGGAGGAAAC AGAGGTGCCCTCCCTGGTAGCTGGGGTGCAGTGACATTGCAATGGCCAGAAGCCAAAAGG CAGACGGTGGCGCTGGAAGCGGAAGCCTTCTTGAGGGGCTCAAGCCACTCTCAGGATGGT GGGCTACAAACCTCATAAGAATAAAGCTGGGGCAAACGTGTCACTAGGCGGGCATGCTTG GCTGGGGGCCAGAGCAGGAGGGCACCAGGGTTGGCAGGGGCCAGCGGGGAAAGCGCCAGG CTGACCCTCTGGGGTGGGTCTCCGGGTCTCTGCTCACGGGCCTCTCTGTCTCCTCTTCAG ACTCACTGCTCCTAAGATCCCAGAAGGGGAGAAAGTGGACTTCGATGTAAGTTTACAGGA CTCTGGTTAACATGTCCACGGTTTCCCCACACCCCAGCTTTTGGGCTCTAGGCCTCAGAA GGTCACTTCCTCCCAAGTAGCCAGAGCCGGGGCCTCCTGGGTCTGGGCAATTCTACCATA GCTTATTCCTGGGCCAGAGGAAACCCCTCTAAGAATAAGCATCTCTCTTCCCTTCTCCTC CATCTATCCTTCTATCCATCCATCCACCCACCCACGTAAGCTCCTACCCATTCACCTATC CATTCATACACCCACCCACACACCCATCCACTCAACCATCTATCCATCCATTCATCCACC CAACCACCCACCTACCCATCCATCCATCCATCCATCCATCCATCCTGCCTTACTTCCATC CATCCAACCAGCCACGTATCCACTCACCCATTCATCCATCCATCCACCCACCCAACCACC CATTCATACACTCACCTACCTATCCACTCACTCATCTCTCCACTCACCTACTCGCTCACC CACCCATCCACCCATCCATCCATCCATTCATACCACTCATTCATCTACTCATCCATCCAT CGATCCATCTATCATCCACTCACTCACATAACCATCCACTCATCCACCCTCCCACCCACC CACCCATTCACCCATTCATCCTCCCATCCACCCACCCACCCACTCACCCACCATCCACGC ATCCTCTACCATTAATCCACATAATCATTCCTCCACCCATCTACCTATCCATCCATTCAT CCATCCATCCATTTCTCCAATCATCCATCTATCCACCCAGTCATCTGTCTCCATCCTCTC TCACTCATCCACCCATCCATCAGCTCATCTGTTCACATGCCTACCTATGTATCCAACAAT TTCTCTCACTCTGCAGTCTTCTCTCTGCCAGGCCCATGCAGGGCATCTCTGAGGATGATG ACAGAGCCAAGTCAGGGCCAGTCCATCCTAAGGATGCTGAGGACCTTATGGCTGGGCACC ATCCCTGCTGTGTGGCTCAGGAATCAGGCCACCCTCGGCCCCTATGAGGATAGCAGCCAT GGCAATGTGGAGAAGGCAAAACATTCCTTGCCACTTGCCATTTTCATGGTGGCCAAGGGA GTCAGGGCTTCTCTGCTGGGGCAAAGGAAGGGACCTCTTGCTGCAAGGCAGGCCAGGCAG GGCAGAGGTTGGAGAGAGGGGTGGGGCTCACACCCACTGCCCCTGCCCACAGGACATCCA GAAGAAGCGTCAGAACAAAGACCTAATGGAGCTCCAGGCCCTCATCGACAGCCACTTTGA AGCCCGGAAGAAGGAGGAGGAGGAGCTGGTCGCTCTCAAAGAGAGAATCGTGAGTGGGGC AGTTCAGGTTGCAGCAGGGGCTGGTGGACTCCCTCGGAGGAGCCGGGGACAGGGCTGAGC AGACCCCCTTCTCTGGCTGCAGGAGAAGCGCCGTGCAGAGAGAGCGGAGCAGCAGAGGAT TCGTGCAGAGAAGGAGAGGGAGCGCCAGAACAGACTGGCGGTGAGGGCACCATCCGCACT GCTGCCTCATCAGAGAATGAGCCCCAGGCCCAGAGAAATGCAGGGGGCTGAGGCCTTCCT TCTCCCGGGGTTCCCATTGTCATTGGCCAATGATCAGAACCACTGGCTAAGGCCCCGGCG CCCTGCAGAACCCCTTGCCAGAAAACAAATCCTGGCCAAGACCTGGAGCTTCCTTCCAGA TAGTTCTAAGCCCAGGGTGGGCCCTTCCAGACAGCTCTAAGCCCAGGGTGGGTCCCTAAA GCCTGCCCAGAAAGCATAGCCCTCTCTCCATCCCTGAGCATCTTGGGAATGGGGTCTCCA CAGGAGGAAAAGGCCAGAAGGGAGGAGGAGGATGCCAAGAGGAGGGCAGAGGACGACCTG AAGAAGAAGAAAGCTCTGTCTTCCATGGGAGCCAACTACAGCAGCTACCTGGCCAAGGTG TGTGCCGCTGCTGGGAGCACGGTGGTAGCCTTCAGTGTGGGCTACGCCCTGTGCCCTCCT GAGACCAGGCCCCTCTCTTTGGGCCTGTCCGCTGCAGGCTGACCAGAAGAGAGGCAAGAA GCAGACAGCCCGGGAAATGAAGAAGAAGATTCTGGCTGAGAGACGCAAGCCGCTCAACAT CGATCACCTTGGTGAAGACAAACTGAGGTGAGGGGTGGGTGTTGTGGGGCTCAGCCCCAC GGGGTGGCCCCTGCAGGAGCTGCCGACTGCTCCTCAGGCTGCCAAGGACCGTGCTCCCCA GTGGCTGCAGGAGGACTCCAGGGGCCTGGCCCTGCCTTTGGGGCTTATTCAACGAAGCCT CACCACTTCCTCTGCCCCAGGGACAAGGCCAAGGAGCTCTGGGAGACCCTGCACCAGCTG GAGATTGACAAGTTCGAGTTTGGGGAGAAGCTGAAACGCCAGAAATATGACGTGAGTCCC GGCACCTCCGGCCCTGGGGCCCTAGCGGCTTTCACCCACCAGCAGAGCAGCCATCTCCCT GCGTCCCTACCAAACTCTGGACCTGCCCACCCCAGGGACCTGGACCCTGAGAGGCCCAAA CAGGCTGTTGCCACGGACCCCTGGCTGAGGCTGCTTTCCTGCTGGGGACTGTGGCCAGAG CCCGTCCTCCTGGCTGGCCATGCAGCGCCCTGAGCGATGAACCTGGCCCCTTTGGGCGGC CTTGGTTACCCCTGCCAAAAGGACTGTCGTGGCAGAGCAGCCATGGCCAAGTGGACTCAG GGTTCATTTTCGGAACCCCTTTAAGCTTATAGAAAGTCCCCATCATCACCCAGCTCGGCC CCGGGGCACCGAGTCCGTCTGGTGTGGGGCGTCCTTTCGACAGAGCCTCCTCCACAAACC CAGACTCTGGCTTCCACCAGGGCCCCGGACACCTGCTTCCTCAGGGCAGACAGAGAGGGG TGACACACTGCACCCTGTGGCTGGGAAAAGGGGCCTGGGACTGTGCCCGTCTGGGACGGA GCAGAGCCACCATCCCATGCAGGCACTATCACCGCAGGCAAAGCTGGGACTGGGGAAGGC AGCCTGCCCGGGCGGCCTCAGGGACTGGGGTACAATGTGGGAGCTAGGGTGGAAGCCAAG CTGCTTCCCACCCTCCCAAACACCCGTTTGGGCTCCAGGGGCGAGGGGTGAGGGGCGCAG CCATGGGTGATCCACGTGCTCGGGGCAAATGCAGACACTCCAGCATCACCATCAGGGCCA CGATGTCCACCCTCCAGCACCGCCAGAGGCCCCAGGGGAGGGCGGCTGTGCCCACGGGGC TTGTGCTCTACCCAGGTGCAGCAGGTGTGGGGCGACCAGTCCAAGCCAGCCGGGCAAATC CGAGCTCCTTCTCGGGGGTTCTGGGCAGGCCACCTGTTCCACCTGAGCTTCCACGAGCTC CCCTCCGACAGAGGCAGGGCGATTACACTCCCTCCCAGAGCTGTCCCCAGGGGGTCCAGG CATGAGGGACAGCCCTGACCTCACCCTTGGGGCTCTCCCAGAGGGGCTGGCCCTGAGACG GGCTTCACGGCACAGGACCCAGGTCCTTCCCATGCTGTGTTCCCAGAGCTGAATCAGGGA CCCACTGGCTTTGGATAGATGCGGCCACAGCGGGCCCCCAGGGGCTCCAGAGCCTGGAGG GCCATCACCAGGCCAAGCTAGCCCACAGCCGGGCCTCGATGCCCCAGCCGCCCATCCAGC CTTGTAACCATCTTGGTCTTTCTAGATCATGAATGTCCGGGCCAGAGTGCAGATGCTGGC CAAGTTGTAAGTAGCCGGGTCCGCCCTGGGCCAGGCCCGTGGGTGTGCGTTGCACGGTGA GGTGAACCTCTCGCATGGCAAAAACCTGGATCGCTCAGGATGCTGGCGGCAGGGGGCCTG GAGCCTTCCTCCTGCCCCCGCTCTCCCCTCGTGCCTGCAGCCGGGGGCTTCCCAGTGGCC GCTGCCCTGTTGGCAAGCGAGGAAGGGCCCCCACCTTCCCAGGAGCTCCGCCTCAAGCCA GCAGCGGCCACAGAGTGCCCCTGGGCACAGGCACGAGGGCGGGAGCGGCTGGCCCAGGAG CAGCAGGGCCGTTCGGAGCTCTGAGCTCAGCGGCTGAAGGGAGCTGGAGCTGAGAAGGAG GGGTCCGCAGGCCTCACCTGCAACCCCTCCCCAGCCCCATCCGTGCTCCGTACCCCCCGC CCCACATCCTGCCGCAGGCTGAAGGTAAGTGGCCAGCTACGGGCTGCTGTGTGTGGCAGT CCAGGCCAGTACAGGCTGGCGAGAGTAAGTCCAGGCATGAGCCCAGGGGCCACGGGACGG TGTCCCCCTGCACAAGGAGCCAGGAGACAGTAAGGGAGCCGAGGAGCCCTCATGGGGGCC CAGCAGCCCTGGGTCGCGCAGCCCAGCCCACCCTGCGGTGGAGACAGGCCTTCACCCAGT ACACGCAGGCCTGGCCCTCGGGTCGTCGCAGTGAGTCACTCATGTTGTTCACAGATCACC ACGCTCAGGAGCCGCATTGACCAGGCCCAGAAGCAGTGAGTAGCCCTGCCGTCCTCGCTC CGCACTGGGCACAGGGGCCCTTGGGGCCAGCCGCTGTAGCCAGTCCCTAACAAGGGCCGG TGGTGGCTGGCCTCGGCAGGGCAGTAACGAGACTAACCCGGCCAGGCCACCCAGGCCAGC ATGCGCAGGCCTGTGGCCAGGGACCCGGAGCCTCCTCCCTCTCCTGCACGCAGGGGAGCC CTGGGGGGTGGCAGAGTCAGGAGGAGGGATCCCAATGGGGCTTGCCTGTCACGCCCTCGC CCCGAGTCTGGCACTGGCTGCAGGGAGAGGGCAGCCAGGGGACCCCTAGAAGGGGCTACT CGGGGGGCCTTTGGTGTGGCCAACCTGGGCCCCAGGGTATCCCGCCAGTGTCCCACCCTC CAAGGGGACCTAGGACAGGGAATTAAGCAGTCAGGGCTTCATCACCAGCCCCTCTGTGAC GCTGGGCAAAATCATGGACTCCTCAGGATGGTGAAACCTCATCCATAAAATCGTGTCCCT GGGGGCTGTGGGATCCCTTGACACAGCTACTCGACCACCTGCATGGGGCTGCACCCAGGG TGCCCCCGGCGATGCCACGCTGGGGATCCTGTCATGGAGCCCAGCTGCACAGCCAGTGCC ATTTCCCCAAGGATCGCAGTGTTTGGGGGCTACTTGGAGTTTCGATGTTTTCTGGGATTC TTCTCCCTCCTCCTGTCGCCTTGGCTTCCCTGCGGCGCCCAGGGCGGGCTCCTCCGTGGT GCACGTGACCTCACGGCCTCCCTGTTGTGCCGTCAGGGGTCATTGCAGACCCCTCTGAGG GTGGGCAGTCGGCGTGGTGTGCATGTGCCTGCGTGTGTGCATGTGTGCATGTGCCGAGAG TGCCCAGGAACGTGTGTGAGGGCACGGCCTTTGCCAGCCAGGTGTCCTGCTGAGCAGCCG CGTCTGAATGGGGCCGGCCTCGCGGGCCGAAGCACTCCTGTCCTCCACCCGCCTTCACCC CTCACCCGCACCCAGCTCCTCCCGGCTCGTGGCCACATGAAGACCTCAGACAAATGGGGC AGGCTCCTGGGCCCCTCAGAGGCCACCGTCTGGAGGGGCATGAGCTCTTTCAAGGCCAAG CGTCTAGGATTATATCATTATCTGCTAAGACAGTCTTCCCCAGCTCAGGGGTCTGTCTGC AGTGGTACCTCAGGCAAAGAAAGGAGGACAGAGGGAGGGTGCCCCGGGCTCACGTGCCAG CCCCCTAACCACACTAACGACCTAGGCCCGCCAGGCACAGGTGAGTGGGCACTGCCCGGA CTGAAGCTGGGTGTGGGCCGCAAGCTTGGGCCGGGCCTGTGCCCTGAGAGCAGCCTGGGG TCGGGCTGAGAGTCCGCCCAGGGTGGGGGACCAGGAGGGGCATGGCCAGAGGCCCTGACC CTGAAGGATCACTTGCTTCCCATTTGCAGCAGCAAGAAGGCTGGGACCCCAGCCAAGGGC AAAGTCGGCGGGCGCTGGAAGTAGAGAGGCCAGAAAGGCCCCTCGAGGCAGAGACCCTCC GCCCTCTTGCACACCAGGGCCGCTCGTGGGACTCCACATCCTCCAGCCCCCACAATCCTG TCAGGGGCTCCCTGACAGTCCTGGGGGTGGAGAGGCCATCCCGGGGCGTCCCCCGCGTCT GTGTCCTTGCTGCCTTCATCCCCTGGGGCCTGTGAATAAAGCTGCAGAACCCCCTTCA OMIM ID 600692