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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for TPO (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID7173
Official gene symbolTPO
Full namethyroid peroxidase
Aliases,MSA,TDH2A,TPX,
Gene summaryThis gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Additional splice variants have been described but their biological natures have not been determined. [provided by RefSeq]
LocationChromosome: 2   Locus: 2p25
Gene position1417233 - 1546499  Map Viewer
Gene orientationplus
Gene size129267 bp
Gene sequence
OMIM ID606765