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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for TRAF3 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID7187
Official gene symbolTRAF3
Full nameTNF receptor-associated factor 3
Aliases,CAP-1,CD40bp,CRAF1,LAP1,
Gene summaryThe protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported. [provided by RefSeq]
LocationChromosome: 14   Locus: 14q32.32
Gene position103243816 - 103372628  Map Viewer
Gene orientationplus
Gene size128813 bp
Gene sequence
OMIM ID601896