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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for Fance (Mus musculus)
(Information is obtained from NCBI Gene database)
Entrez gene ID72775
Official gene symbolFance
Full nameFanconi anemia, complementation group E
Aliases2810451D06Rik,AI415634,AW209126
Gene summaryThis gene encodes the complementation group E subunit of the multimeric Fanconi anemia (FA) nuclear complex composed of proteins encoded by over ten Fanconi anemia complementation (FANC) group genes: FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The FA complex is necessary for protection against DNA damage. This gene product is required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2. Defects in the related human gene are a cause of Fanconi anemia, a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. Translation of this protein is initiated at a non-AUG (CUG) start codon, which is inferred from the related human gene and the notion that this protein is functionally indispensable. Multiple transcript variants encoding different isoforms have been identified. [provided by RefSeq]
LocationChromosome: 17   Locus: 17 A3.3
Gene position28450475 - 28463519  Map Viewer
Gene orientationplus
Gene size13045 bp
Gene sequence