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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CDK11A (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 728642 Official gene symbol CDK11A Full name cyclin-dependent kinase 11A Aliases ,CDC2L2,CDC2L3,CDK11-p110,CDK11-p46,CDK11-p58,MGC131975,PITSLRE,p58GTA, Gene summary This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L1, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L1, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions, which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L1 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Many transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of only two have been determined so far. [provided by RefSeq] Location Chromosome: 1   Locus: 1p36.33 Gene position 1655791 - 1634169  Map Viewer Gene orientation minus Gene size 21623 bp Gene sequence >CDK11A:complement(1112801..1134423):Length=21623 ATCATTAGGCGTCAACACAGGAAGTGAGGATACTTCTGGCGAGCGCCGGTTGCTGTTTCT TCTCAGGCTCAGGGACCGGCCGCGGCCCCGTAGGGGTGAGTTCCGACTGGGCGGACCAGG TGTGGGAGCGCGACGAGAACTGCGCACCGAGGTCTTTCTTCCGAGCAGGCCTCGGAGCGG GGCGGACCCGGGCCCGGGGGCGAGCGACACCCTCGCTTCCGCGGACAGTCTCATCCCGCA CGGAACTTTGGGTGGTGGAGGCGGCGGGTCCAAACGCTGTCTGGAGCCAACGTCTGCCAG GCTGAACCTCAAGTGTGCGGGACTGAACCCGAGGAAATAGCCCAGTGCCCGGGTCAGGTG GCCTTGTTCGCGAGCACATCTCGGAGCATCTCCCCGGTCTCAAGGTGCAGCTGTCCAGTG TGCTAGTGGCTTCACGTAGTCCAAGCGGTCTTTCTAGCAGATTCTGACAGTAAAAGCAGT GTTTGATGAGTGGCAGGTCCTGAGTTAAGAGCCTTTAAACGGATGATCTTTAATCCGCGA TCGATACTATCACGTAGGTGTTGTTATTCTGGTTGTACGGAAGACTGAACTGAGGTGAAT TACGTTACCCAAGACCATACAAGAATGACAGAAACGAGACTTGATTTCAAGCGGTCATTT TTCAGAACCCATCACTCTTTTTTGTCGCCCATGCTGCAGCGCAGTGGCTGTTCACAAGCG CACTTCAGCCTGGAACTCCTGGGCTCAATCGGTCTCCCATCTCAGCTTGCAGAGTATATG GGACTACAGGCGCTCGCCACCTTGCCTGGCTTACAACTTATCATTCTTGTTTTTTTTTTT TTTTTTTTTTTTTTTTTTTTTTTTGAGACGGGGTCTTGCTGGAGTGCAGTGACGCGACCT CGGCTCACCGGAACCTCCGCCTTTCGGATTCAAGCGATTCTGCTGCCTCGGCCTCCCGAG TAGCTGGGATTACAGGCACCCGCCACCACGCCCAGCTAAGTTTTGTATTTTTAGTGGAGA CAGGGTTTTCGCCGTGTTGGCCAGGCTGGTCTTGACCTCCCGACCTTGTGATCCACCCGC CTCAGCCTAGAGCTTACCTTTTTTTTTTTTTTTTTTTAACCAAGTCTTACTTTGTTATCT AGGCTGGAGTGCAGTGGCGCAGTCTTGGCTCATTGCAGCCTTGACCTCTCTGATTCAAGT GATCCTCCTGCCTCTAGCAGCCTCCTTCCTGTAGCTAGGAATACAGGCACGCGCCACCAC ACTGGGCTAACTTTTGTATTTTTTGTAGAGACGAGGTTTTGCCATGTTGCCCGGGCTGGT GTTGAACTCCGGAACTCCAGCGATCTGCTCGCCTCGGCCTCCCAAAGTGCTAGGGTTACC GTCTTGAGCCACTGCGCCGGGCACAACTTCTTATTCTTAATGAGGATTTATTCTGAATCC CTCAAAAGTGACTAGGTTCAAGTGTTCAGCACCATAGCTTGCTGTGTCCTGATGTAGGCT GAATTATTTTTCTTTTTGCAGTGTTTTAACTCAAATGGGTGATGAAAAGGACTCTTGGAA AGTGAAAACTTTAGATGAAATTCTTCAGGAAAAGAAACGAAGGAAGGAACAAGAGGAGAA AGCAGAGATAAAACGCTTAAAAAATGTAAGCCATATTTTTTTAAGTAAGTGGTTTTCTTA AAGGAGATTTAATTTCTTTGCCCTCATTTTTCCATTAGAACAACGCTTCTTCGGTGAAGT TCTTTTGTACTTCCAAATGTCGCAGGTGAGCCCAAAATGTATTCTAATATTCAGTTGACA TTAAAGGCAGATTTAACACACTAAAGCTGTGTCTAGATTGAGCATACATGGAGAATAAAA TACGTTGAATGTTAAGTCATTAGCAAAACTGGACTAATTTTTCTCGGTTCATTATTAGTA TATTCATAATACTATCTCTAAGTATTTTTAATATAGTGGGAACTTGCCTTGAAATTAATA TAAATATTTTACGTCTTTCTTGGTTTGCATGGTAATGTACTCAGGAAACCTTTTTAGTAA TTTGGTAAGAGGCATTGGCAAAGTACCTCTTTTGCTAAGATTTGTAGCATCATTTGGGAT GTTAGTGAGTACAGGCATACCTTGCACTTCACTTTATTATGCTTCACAGATATTGAAATT TTTCCAAATTAAAGGTTTGTAGCAACTCTGCTTTGAGTATTTTTCCAATAGCATGTGCTC ACTTTGTTAGCTTTTTTTTTGTTTTTGAGACGGAATCTCGCACTGTCGCCCAGGGCCAGG TTCACACCATTCTCCTACCTCAGCTTCCTGAGTAGCTGGGACTACAGGGGCTCACCAACA TGCCAAGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTCTCTCCGTGTTAGCCAGGATG GTCTTAATGTCCTGACCTCGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTAAC AAGCGTGAGCCACTGCACCTGGCCAAAAATTCTTTATATTTTATAACACTGGCTCATTCA GAGTACATGTGAAAGTTTGTTTTGGGATGTTGCCCAGGTTTGATTATCATTAAAAATACT TTTATCTATGAAGAAAAAAAAACTTATAAAGAAAATGATTAACTTTCTCTTTGCTTCTTA GTCTGATGACCGGGATTCCAAGCGGGATTCCCTTGAGGAGGGGGAGCTGAGAGATCACTG CATGGAGATCACAATAAGGAACTCCCCGTATAGAAGAGAAGACTCAATGGAAGACAGGTG AGCGGATGTACAGATGTGCAAGACCCAACTGTACACAGCCCTGGCCTGGCCAGTCCTTCC TAGGGTCACTGTGACAACTGTGTGCTATTGTAACTATTAAGGTTTACTCTTTCCTAGAGT TACCGTGACAGGGCGTGTTGTAGCTGTTGTACTACTGAGATTACTCTTTCCTAAGGTTAC CGTGACAGGGTGTGCTGTTGTAACTATTGAGGTTTACTCTTTCCTAGGGCTACTGTGACG GGGTGTGCTGTTTTAACTATTGAGGTTTACTCTTCCCTAGGGTTACGTGACGGGGTGTGC TATTGTAACTATTAAGGTTTACTCTTTCCTAGGGTTACTGTGACAGTGTGCTCAGTGTGC TGTTGTAAATACTGAAGTGTACTCTTTTTTTTTTTGAGACGGTGTCTCAAGAGTCTTGCT CACCCAGGCTGGAGTGCAGTGGCGCCATCTCGGCTCACTGCAAGCTCCGCCTCCCTGGTT CACACCATTCTCCTGCCTCAGCCTCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAA ATACAAAAAATTAGCCAGGATGGTCTCGATCTTCTGACCTGGTGATCCGTCCACCTCGGC CTCCCAAAATGCTGGGATTACAGGTGCGAGCCACGACCTAGGATTACTGTGACAGGGCAT GCTGTTACAACTATTGAGGTTTACTCTTTCCTAGGGTTACTGGTGAAAGCCTGTCTCTAC TACAAATACAAAAATTAGCCTGGCATGGTGGTGTACACCTGTAGTCCCAGCTACTCAGGA GGCTGAGGCAGGAGAATTGCTTGAATGTGGGAGGCAAAGGTTGCAGTGAGCCAAGATTGT GCCTCTGTATTCTACCCTGGGGGACATAGCAAGATTCTGTCTGAAAAAAATAATAAGTCC GGGTGCGATGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCAT GAGGTCATGAGTTTCAGATCAGCCTGACCAATATGGTGAAACCCCGTCTCTACTAAAAAT ATAAAAATTAGCTGGGTGTGGTAGCGCACGCCTGTACTCCCAGCTACTCCGGAGGCTGAG GCAGGAGAATTGCTCGAACCTGGGACAGGAGGCAGAGGTTGCAGTGAGCCAAGATTGCGC CGCTGGACTCCAGCCTGGGCAACAGAGCGAGACTCCATCTCAAAAAAATAAATACAGGCC GGGCGTGGCGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCAGATCAC AAGGTCAGGAGATCGAGACCACCCTGGCTAACACAGTGAAACTCCGTCTCTACTAAAAAA TACAAAAAAAATTAGCCGGGCGTGGTGGTGGGCGCCTGTAGTCCCAGTTACTTGGAAGGC TGAGGCAGGAGAATGGCATGAACCCAGGAGGTAGAGCTTGTAGTGAGCCGAGAGTCTCGC CACTGCCCTCCAGCCTGGGCGACAGAGCAAGACTCCAATCTCAAATAAAATAAATAAATA AATAAAATTAAATTAAATAAATAAGATGTGATGTATTTTTACATGCCCCTGAAACTGTCA CCACAGTCAAGCTAATGAACCTGCCCCTCACCCCCTGCAGGTCCTCTGAGAGGCATTTCG TTCCATCTGCACAAAACATTGATTTCTTACATTTTTCATCTGAATCTTAAGACTCCTAGG CCGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAAGCCGAGGCAGGCAGATC ACCAGGTTAGGAGATTGAGACCATCTTGGCTAACACAGTGAAACCCCGTCTCTACTAAAA ATACAAAAATTAGCTGGGTGTGGTGGCGGGTGCCTGTAGTCCCAGCTACTCCGGAGGCTG AGGCAGGAGAATGGTGTGAACCCGGAAAGGTGGAGGTTGCAGTGATCCGAGATCGCGTGT CTACACTCCAGCCTGGGTGACAGAGCGAGACTCCGTCTAAAAAAAAAAAAAAAAAAAGAT GCCTGAAGTTGGAGAATTAATGTAATTTTTTAAATGATGTTTCAGCTTCGTTCCTATCTG AATCATGCATTTTTCTGGGTTGAAAAAACCTCATAATAGCCTGATGCTTTTCCGCACTTT CTCAAGCATGACGCAGTGCTGTTGTGTTTTATTTCAGAGGAGAAGAAGATGATTCTTTGG CCATCAAACCACCCCAGCAAATGTCTCGGAAAGAAAAAGTTCATCACAGAAAAGATGAAA AGAGAAAAGAAAAATGTAGGCATCATAGCCATTCAGCAGAAGGGGGTACAGAAGCATTTA CTTTCTTTGACATCATGTTCAAGTGTGGTTTCTTTCCTGTTCCTACTCTTCTGCCTTCCC CAGAGCACCACTGAAAAACCAGAGAAAGCAAACTGTAGCTGAAAGCATAATGGTGTCACA GACCGTTCAGAAGGGCTATAGAGAGAATAGCTGAAAGCATGCATGTGTCACAGACCATTC AGAGGGGCTATAGAGAGCAAACTCTAGCTGAAAGCATGTGTGCGTCACAGACCGAAAACC AGAGAGAGCAAACTAGCTGAAAGCATGCGTGTGTCACAGGCCATTCAGAAGGGCTATAGA GAGAGCAAACTCTAGCTGAAAGCATGCGTGTGTCACAGACCATTCAGAAGGGCTATAGAG AGAATACTCTAGCTGAAGGCCGGGCGTGGTGGCTCAAGCCTGTAATCCCAGCACTTTGGG AGGCTGAGGCGGGTGGATCACAAGGTCAGGAGATCAAGACCATCCTGGCTAACACGGTGA AACCCAGTCTCTACTAAAAATACAAAAAATTAGCCGGGCGTGGTGGCGGGCACCTGTAGT CCCAGCTGCTCTGGAGGCTGAGGCAGGAGAATGGCATGAACCTGGGAGGCGGAGCTTGCA GTGAGCCGCTATCGCACCACTGCACACTCTAGCCTGGGCGACAGAGCAAGACTCCGTCTC AAAAAAAAAAAAAAGAATACTCTAGCTGAAAGCATACGTGCGTCACAGACCGTTCAGAAT GGCTATAGAGAGAATACTCTAGCTGAAAGCGTGCGTGTGTCACAGACCGAAAACCAGAGA GAGCAAACTCTAGCTGAAAGCGTGCGTGTATCACAGACCGAAAACCAGAGAGAGCAAACT CTAGCTGAAAGCGTGCGTGTGTCACAGACCATTCAGAAGGGCTATGGAGAGCAAACTCTA GCTAAAAGCCTGCGTGTGTCACAGACCGAAAACCAGAGAGAGCAAACTCCAGCTGAAAGC ATGCGTGTGTCACAGACCGTTCAGAGGGGCTATAGAGAGAATACTCTAGCTGAAAGCATG CGTGTGTCACAGACCGAAAACCAGAGAGAGCAAACTCCACCTGAAAGCATGCGTGTGTCA CAGACCATTCAGAAGGGCTATAGAGAGAATACCCTAGCTGAAAGCATGCGTGTGTCACAG ACCGAAAACCAGAGAGAGCAAACTCTAGCTGAAAGCATGCGTGTGTCACAGACCGAAAAC CAGAAAGAGCAAACTCTAGCTGAAAGCGTGCGTGTGTCACAGACCATTCAGAAGGGCTAT AGAGAGCAAACTAGCTAAAAGCATGCGTGTGTCACAGACCGAAAACCAGACAGAGCAAAC TCCAGCTGAAAGCATGCGTGTGTCACAGACCATTCAGAAGGGCTATAGAGAGAATACTCT AGCTGAAAGCATGCATGTGTCACAGACTGAAAACCAGAGAGAGCAAACTCTAGCTGAAAG CATGCGTGTGTCACAGACCGTTCAGAGGGGCTATAGAGAGGATACTCTAGCTGAAAGCGT GCGTGTGTCACAGACCGAAAACCAGAGAGAGCAAACTCTAGCTGAAAGCATGCGTGTGTC ACAGACCGTTCAGAGGGGCTATAGAGAGGATACTCCAGCTGAAAGTGTGCGTGTGTCACA GACCGAAAACCAGAGAGAGCAAACTCTAGCTGAAAGCATGCGTGTGTCACAGACCGAAAA CCAGAGAGAGCAAACTCTAGCTGAAAGCGTGCGTGTGTCACAGACCATTCAGAATGGCTA GTCCATTTTTCCTCTGGGGTTTTCTCTCCCCCATTATATTGTTTGGGAGCAGTTTGTTTA CATTTAAAATGACCTGAATTCAACAAGTATAGGAGAAAAACACACCCCAAAATGGGTATT TGCTCAAGTCCAAAGAATGGGTTAGGCTTGAGCAGTTTGATCTCGTACCAACATCAGGAG ATTCTTACGGGTGTTAGGAAAATTGGACCTGGAGCCCGATTGAAATCTCATTATTATAAA TACGCTTGATTAATTAATGTGGCTTCATTGCACAGTGGAGAAGCCCACTGATAGCAAAGC TTTGTTCTGTAGTCTTTGTGAAGAGTGGTTTTTGTATTATAAAACTGATAATTATAGTTT ATTCAGTATAGAAAATTTTTAAAAGATGAATATTACAATTCTCTTCTGTGATAGCAGAAT TGTTTTTCTTTTTTCTTCTTTCTTCATAATTAGACGCTTACTGCAGATAGTTTTCTATTT TCAAAGTTTTTTATTTAACATAAAATCATGATTATTCGACTGGGTGCAGTGGCCCAGGCC TGTAATCCCAGCACTTTGGGAGGACAAGGATGGAGGATCACTTGAGCCCAGGAGTTCAAG ACCAGCTTGGCCAATATAGTGAGACCCTGTCTCTTCAAAAAAAAAAAAAAAAAGATTAGG ATTACTTAACATCATTATTTAAATATTTAATGTTCTTGATTTAATTTCATTTTCATGTGA TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTCACTTTTTCG CCCAGGCTGGAGTGCAGTGGCACGATCTCGGCTCACCGCAACCTCCACCTCCCAGGTTCA AGTGATTCTACAGCCTCAGCCTCCCTTAGTACCTGGGATTACAGGTGCCTGCCACCACGC CCAGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGTTT TGAACTCCTGACCTCAGGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGG CGTAAGCCACCGTGCCCGGCCTCGTGAAATTTTTGAAGTGAGGTTTCTTTGCATGACACT TTATTTCTCATTAGGGAAGCATGCTAGAGTGAAAGAAAGAGAGCACGAACGTCGGAAACG ACATCGAGAAGAACAGGATAAAGCTCGCCGGGAATGGGAAAGACAGAAGAGAAGGGAAAT GGCAAGGGAGCATTCCAGGAGAGAAAGGTGAGTGGGCTGGGTCAGTTGAGGACTTTATGA AAGGGCCGTGGTAGTGTGTCCTGTCACAGCAATGAAGAAGAATTTGGCAATAGAAGTCAC ATTTGTTGCAGAAGTGGTAGACATGGAAACAGCACAGTGAACGCTGGACGAGGCTGACCA AGAGAACTGTCCTGAGGGAGTGAGTTTTCACTGCATCTGGAAGTAAGAACGGGTGTGATT TGATTGAGGGAAGACAATGAAGGGATCAGAAATCTGCACGTCCCGCCGGGCGCAGTGGCT CACGCTAGAATTCCAGCACTTACGAGGCTGAGGTGGTTGGATCCCTTGAGCCTGGGAGGT CAAGGCTGCAGTAAGCTATGACCATGCTACTGCACTCCAGCCTGGTTGACAGAGTGAGAC TGTCTCAAAAAAAGGAGAAGGGAGATCCCAAAAACCTTGAAACAGTCTGGAAATCGGGAC ACTGGACTCCTAGGACTCCTGGCCATTAGTCTGTATATTCGTTCCCCTTTATGAGCCAGA TTCCCAAGAAAGAACATCGGTGTAGCCCCAGATCTGTTCTGTGAACCAGGAAAAAGGCTG TAGGCCAGGTGCGAGCAGGCCCATCTCCGCCTTCAGAGTGAGTCCACAGAAAGCTTGCAA GCTGCTCCAGGAAGAGAGGAGTCTGAAGCGGAAGGGCGTGTGCAGCGATGTTTGCCAGCA GCCAGGGCTGGGTACACAGCATGTAAAGATGATGAGAGGGCGCTGGTTCTTGTTGATGCC GAAGGGTGTGGGAGACACTGAGGCCCAGGGGTCAAGGTCCGAGACCGCTGCTGGGTGAGC AAGGTTTCAGTTGGCCTAGTTCCTGTTAGTGTGTGAAACATTCATGTATGCCACGCCCTG TGCCAGACATTGAGTGTGTCTTGTCCCACGAGAGTAGAGCTTGGGATAGAAGTGGAGGTT GGTAGATGAAATTTGGGCTGTCATATTGATTTCCCAGAAGGTAAAGACAGGAGAGTGAAT GAACAAAAATTGTTGGGGGCAGACTTCTGGGTAGGGCCGATTCAGATCAGCCAATCCAGA ACTGGGTGTGGTAGCATATGCTACGTGGGAGGCTAAGGCCAGAGGACCGCATGACGCCAG CCTGGGCAACGTAGAGAGACCTTGTCTCTGACAAAAAGGAAACTGATAAGGATAATCTGA GAAGCACTGATGCTTGGAAAACTGCTGAGCTGTGGGTAAAAGCAGTAAGAATCTGACCTT CTGGCCTGAGAGCTGCTCCCTTTACTGCTTCCACTCTGCACTTGGAAGCACGGAGGTTCC ACTGGGACAGGGCAGCTGCAGGACCTGCAGTTTCCTTGCTGCCTTGGAAGGGGTTACTCC GTTTAGAGCAGTGGGCAGTGGCCTTGCCCACCAGCATCCTCAGTGGAGGGAGGAAAAGGC CAAGAGGTCTGCTAGAATGAAGTACAGTGTGGTTGGGAGCAGCTGTGATCCCGCCAAAGA CGTGCAGCAGAGACTGGAGAGAGCTCGAGCCGCCACCCACTTGTGACCAGCCCTGAGGAT GCAGCTGCGTGAAAGGACCTAGCAGAAAATAGAAGCCGCCACAGATGCGAATGACGCCTG AACGTTCAGTGTGCTCCCTGTCCACACACAGCCGTGGGCCAAGGAAGCCTTACTGTGCTC GAGGTATTTGAGCCCAGCCTTTTTCCAGTGCTGGCTAATTGCTAAGCTGTGCAGCCATGG TGGTGACCCCTAGGAAGCCAAGGTTGAAAATTAAAATAGGCATGTGGGAAGGAACGGGGT GGCCATGAGCTATGAGGGAGATGGATTTCACGGACAACCAGACAGGCCTTGGTGGTAACA ACGAAAGGGAAAACTTAGAATCCAGAATTGCTACAAATGTATTATCTAAAATACAAAGAA GTATGACAGTGTGACCCGTACTGAGGAAGAACATCATCAGTAGAAACTGTCTTGAGTGTC CAGATGTTGAATTTAGTAAAGGCTTGGAAACAACTTGTGGATGGAGCAGTAGAAATTATC CATTCTGAAGAACAGAGAGAAAAAAACAAGAAAAATGCACAGAGCCTCAGAAACCCGTGG TACAACATCTGCTGTACCAAAGCACGTCGAATGGGGGTTCCAGGAGAGAGGAAAGATATT TGTTACAATAATGGTTAAAAACTTTCCAAATTTTAATTAAAAAATATGCACATTCAAGAG CACAGGAAGTTTGAACTAGAATAAATGCAAAGTCACATCATAGTCAAACTGGCAAAGGCC AAAGAGAAAATGTTGAAAGGGCTCAGAGAAGAATGACCCATCCCATGAAAGGGGAGCTTC AATACCGCCAGCCACTGACTTCTTAGAAACAATGGAGGCCAGAAGGCAGTGGAGTGGCAT ACTCAAGCTGCTTAGAGAGAAGAACCATCAGCCAGGAATCAAAACTGTTCTACACAAGTG AAAGGGAACGAACGACATTCCCTGAGAAGCAGAGACTGGTGGGATTCATTGTTGGCGAAA CCTGCCTTAAAGGAAATACTAAAGGAAGACCTTCAAGTTGAATAGAAATGACACCAGACG GTAACTTGAATCCTCAGGAAGGAAGGACAGGCACTGCAGATAGCAAGTGTAGGTTGACGT CAATATCCTGTAAATATCTCTCCTCACATCTTAGGTTTTACTGGAACTACGATTGTGTAA AATAATTACACTGTTGTCGTGGTATGTGGCATAAATGGACTGCACAAAGAAGACAGGGAA TGAAGCTGTGTTACAACAGTTTTATATTGTACTGGACTTGAGCTAGTATCATGAGGCATA TGGTGATCCCTAGAGCAACCACTAAGAAAGTTGTTTTCTTAGTGTTCTAAAAAGTACAAA TAAATTAAAATGGTATGCTAAACGTATGTAATTTAAAATCAAAAAGGGAAGAATAAAAAA GACACAACAAAGCAAGGAAAGTAAATCCAACTGTACGTGTAATTATATGACATGTGAAAG GTCTCTGTGCCCCAAACAGACAGGGCAGATTATCAGATAGAAAAACAAGATCTAACTGTA TGCTGTCTGCTAGAGAACAGGAAAAGACGCAGCGTACAAACATCAGCTGTCATAGGAGAG CTTGAATGGCTGTACTCATACCAGACAAAACAGATGTTAAGAAATATTAGAAACCAGCCT GGCCAACATGGTGAAACCCTGTCTCTAGTAAAAATACAAAAATCACCTGGGTGTGGTGGT GCACACCTGTAATCCCAGCTACTCGGGAGGCTCAGGTATGAGAATCACTTGAACTCGTGA GATGGAGGTTGCAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGTGACAAACCAA GACCCTGTCTCAAAAAAAAAAAAAAAGCTAGAAACAAGAAGGAGCAAGGACTTCACAGCC AGAAACAGGCCAATACAGCAGGAAGATACAGCAATGATACATGTGAATGCATCTAACCAC AGAGCCCAAAATCCATGAAGCAAACACCGATCGAATGGAAAGAAATGGATCATTTATTAA TTAGAATTGGAAATGGCAGCTGGGCACGGTGGCTCGGGCCTGTAAACCCAGCACTTTGAA AAGCGGAGGCAGGCGGATCACGAGGTCAGGAGATTGAGACCATCCTGGCTAACATGGTGA AACCCTCGTCTCTACTAAAAATACAAAAATTAGCTGGGAGTACAGGGCGCACGCCTGTAA TCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTCGAACCCGGGAGGCGGAGGTTGC AGTGAGCCGAGATCGCGCCACCGCACTCCAGCCTGGGGGACAGATGAAGACTCCGTCTCA AAGAAAATAAAATAAAAAAATGAAAAAAAAACTTCACGGATTGAATTACGTAGAAAGCCA GCTTACAAATGTGGACAAAAACGCGATAAGCAAGCTTCTGTTTAGGGGGAATGATGGCGT GTGCCTCTTCAGGGACCGCTTGGAGCAGTTAGAAAGGAAGCGGGAGCGGGAGCGCAAGAT GCGGGAGCAGCAGAAGGAGCAGCGGGAGCAGAAGGAGCGCGAGCGGCGGGCGGAGGAGCG GCGCAAGGAGCGGGAGGCCCGCAGGGAAGGTAGGCGGCGCGGTGGGCAGCTGTGCTCGGC GGGACGCGTGTCTGCTGCCCCCTGGTGCTGGGCACTTGCTGTCACAGGCGGGCGCTTGGT TCCGGTGCTTGCTTTTCGCCCCTGCCTTTTTTTTTTTTTTTGGAGGCAGAGTTTTGCTCT TGTCCCCCAGGCTGGAGTGCGGTGGCGCGATCTCGGCTCACTGCACCCTCTGCCCCCCGG GTTCAAGTGATCCTCCTGCCTCAGCCTCCGGAGTAGCAGGGATTACAGGCACCCGCCACC ATGTTCAGCTATTTTTTTATATTTTTAGTAGAGACAGGGTTTCACCGTGTTAGCCAGAAT AGTCTCTTGATCTCTTGGCCTCGTGATCCACCCACCTCGGCCTCCCACAGTGCTGCGATT ACAGGCGTGAGCCACCGCGGCCGGCCAGTACGAGCTTTTATAGTCACCCACGTCCTCACC TTAATGGAGATCTTTATTTCTTCACCCAGCTTCCGGTTTCTGTCTCGCGTCCTTTCCTTA CACCCCACACAACTCCCTGGAGCTTATTCTTCAAGGCAGGTCTAGGTCTAGTAGTAATGA ACTCCCTCTGCTTTTGTTTATCTGAGAATATCCTCATTTCTCCCTCATCTTTGAAGGAAA GTTTGCTGGATACGTGGTTCTTGGTTGACAATTTTGTTGTTGTTGTTTTGAGACAGAGTC TTCTTCTGTTGCCCAGGCTGGAGTGCAGTGGAGCGATCATAGCTCACTGCAACCTCGAAC TCCTGGGCACAAGTGATCTTCCCACCTCAGCCTCCCGCGTAGCTGGGACCTACAGGCGTA GCGTGTGCCACCACACCTGGCTCATTTTTCAGTAGAAACAAGGTGTCCCTGTATTGCCCA GGCTGGTCTTGAATTCCTGGGCTCAAGGAACCCTCATGCCTAGCTGACAGTTTTTCCTTT TCACTTGGACTATTTCAGCCCATTGTCTTCTGGCCTCCAAAGTTTCTGATGAGAAATCTG ATGATCTTATAGAGGATCCCTTGGATGCTTTAATCTGATGACCTAATTGAGGATCCCTTG GATGCTTTGAAGATTCTCTTTGCCTTAGGCTTTCAACTGTTTAATAATGGGTTTTCCTGT GGGCCTCTTGACTTCATTCTACCTGGAGTTCACTGAGCCTCTCTAATGTTTATATTTACG GTTTTCATCCAATGTGGGGGTTTTGAGGAATTCTTCAGATACCCTCTCTGCTCCTCTCCT CCCTCCTGGGCTCCCACAGATCTGTTGGGGTCCCCGAGGCCGCTCAGCACTGCTCCCTTT TCTTCAGTCTCTTCTGCTTTCTTTTCCTCAGACGATGTGATTTTATTGTCTTCAGGCTCA CCGATTATTTCTTCTGCCTGCTCACATCTGCCTGTGAGTTTCTGTTGTGAATATTTACTT TTTAGTGTCTATTGTGAGCATGTACTTATTAGCTCTGGAATTTCTCTCTGGTTTCTTGTT GGATCTTCTGTCTCTGTTGATATTTCCGTCGTGTTCACGCGTCATTTTCTTGACTTTCTC CACATCTTCCTTTCGTTCTCTGAGGAACTGAAGGTTTAAGACAGTTCCCTAAAATCTTTG TCTGGGACATCTACCGTCAGGTGATTTTCAGGAACCGTGTCTGTTGGCTTCTTTTTTTCC CCTCTGAATGGGACATACTGTCCTGTTTCTTTGTTTCTCTTGTGTTTTTCTTAGTCAAAA AAATGGACATTTGATTCTCATGATGTGATTCTTCCTGGTCCCCACTCAAGGGTGTGCACT TGTTGTTTTGGTTGTGCTGGGCTGTGTCTGTGGGGTCGGCCTGTTGTGGAAACTCAGGGT CTTCACGGGTCTTTTCTGAGCCTGAGCCTTTTCCTGGTCACGTGCAGCCACTTTTTAACG TTCCCGTCAATACAGATGTTTTTAATGTTCTTGTCCTGAAGTGTCTGCCTCCTAAAGGGG GAATAGAGAGAAATGAAGGGGGCAACGGGGGACGTGGTGCTCATGCCCTGGAAGTACCTT CAGCTTGGGGGTGGCCGTGGCTGCTGCCTCTTCATGCCTCTGGGGTGGGACACGCAGTCA TCACACTGACCTCGGGTGTGTGTGTCCGTCTGCCCACCTGGGTCCGGCGAGCTGCATGCA GGCTGCTGCCTGCCAGCGGGGAGTGAGGTGGGAGCCACTAATGTGCGAAGCGGTGACGTT GATTAATGAATCACAGTTTACTCTCCAAGATTCCCCCTGAAGTTGCAAACCTTCAGTAGA CTCCAGAGCACCTCAGTAGTTGCACAGGCCTGATCCTGTGATGCAAGTGTTGTCTCGGTG GGGAGACTGATTCCCAGTGCTTCCTACTCCATCTTTCCAGAATCTTCTCCCGCCCCTTCC TTTTTGACCAGTGAAGATCAGTCTAGAAGGTCCACCTGGGTCCTCGGGCTCACGGCCTCC AGGTTGGAGCTTTTTCTCCCTGGGCTTCCTGGGAGACCTCTGGCCTCTGACCCCGATGCT GTCAGCACCCTGTGCACGCTGTGGGTGTGTCTGCCAGGTGCGGGTGTGGGAGACGAGGCA GCTGTGCCGGGTGGGGCCTTTTGAGGAAGGCAGTGCTGCTAGTGCCATCTCCCTCTCTGC CCTGCGCGCCAGTGTCTGCACATCACCGAACGATGAGAGAGGACTACAGCGACAAAGTGA AAGCCAGCCACTGGAGTCGCAGCCCGCCTCGGCCGCCGCGGGAGCGGTTCGAGTTGGGAG ACGGCCGGAAGCCAGGTGAGGCCAGGCCGGCGCCTGCGCAGAAGCCAGCACAGTGTGAGT CTTTTCTGGGGGATGTTTGGCATAAGTGTGTAGGATTCATTTAAAGCCCAGCTAAGTAAC CGCTTCAGAAGAAAGTGAGAGATGTGCTGGCTGAAGTCCTCTCGTGTCGTGAGAGGGACC GTGAGTGTCTGTGTGCGGCCAGGACACAGGACGTGTGTTTATCCGCTGGGACATTCGCCA CTGGCCCCGTTAGAGAAGTGGCTTCCAGCGTCTGTGGATGAGCTGGTTTCCGACCAAGCA AAGTTAATCGTTACGTGAAAGGCACTAGTTTTGGGGTGGTGGTAGCTTGTTTGTTTAAAA ACATTTCCCCAAATTCACCTTTATGGTTTATCTCATAAGTAAAAGAAGAGAAAATGGAAG AAAGGGACCTGCTGTCCGACTTACAGGACATCAGCGACAGCGAGAGGAAGACCAGCTCGG CCGAGTCCTCGTCAGGTACCTGGAACCGCCTGGCCAAGGCCTTGACCACTGCTGCCCAGG AAGGCCCAGGTTCACCCTCTGCTCTGCTGTCTTTCTACAGCGGAATCAGGCTCAGGTTCT GAGGAAGAAGAGGAGGAGGAGGAAGAGGAGGAGGAGGAAGGGAGCACCAGTGAAGAATCA GAGGAGGAGGAGGAGGAAGAGGAAGAGGAGGAGGAGGAGACCGGCAGCAACTCTGAGGAG GCATCAGAGCAGTCTGCCGGTGAGGCACCGCGACGACTGTGTGAGGTGTTGTGACTTCAC TATAGTGTTAGAAACCGCAGAGAAGTAGCTGGCGGGCGGGGGAGTTGAAACTCCCTTCTA TCTAGGACTCTCTCGGGACACCTCCACATCGATTCTTTTTGTTTGTTTTTTTGAGATGGA ATCTTGATCTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTCGGCTCACTGCAACCTCT GCCTCCCGGGTTCAAGTGATCCTCCCGCCTCAGCCTCCCAAGTAGCTGGGAGTACAGGTG TGCGCCACCACGCCCGGATAATTTTTGTATTTTTAGTCGAGACGGGGTTTCACCACGTTG GCCAGGATGGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCGGCCTCCCAAAGCA CTGGGATTACAGGCGTGAGCCACCGCGCCCAGCCTCCATATCCATTCTTGGGAACACTTG TTGCTTAGCTGAAGCGGAGCCCGCATCCTGCCTGTGGCAGCACTCGCCCCGGTGCTGGTC TGAGCAGACGCCTCCTTTCTCTTGCAGAAGAAGTAAGTGAGGAAGAAATGAGTGAAGATG AAGAACGAGAAAATGAAAACCACCTCTTGGTTGGTAAGAACCTCCCTGGAGACAGAGCCC CCTCCTTGTCTGTCTCCGAGTGCAGCAGCCCTCTCCTAAGACAGCCGGTCCTGCGCGGCG TGGGGCACGCCAGGGTCTGGGAGGCCGCCTGATTCGTTGGCCGCTCCAGGCTGTGCCGGT GGGGCCCGCATTCCTCAGCGAGGCACAGTGCTGACCAAGGGCGTCCTGAGTGCCCAGCAG GGCCGAGGAGCTGGGAAGCCCAGGACCAGTTCCCCACAGGGGAGGCCCGTCAGATGGTGG CTCCGGGCCTGTCCCTGCAGAACAGAGGCCTGGCCCAGCCTCCGACAGGCAGTGAGGTTA TGTCCTCAGCCTGGTGGACGTGGATGTGGGCTTGTCCCCCACATGACACCCGACGCCTCC TCCCAGCTCAGCATCCGGGCTCTGTCTCAGCCGAGCCTGCCAGCACTCTTAGGCCTCGGT GCCCTGTGTCCAGGGGACGAGAGCCCAGCGCCAGCACCTCCCAGCGGGACACGGGGCAGC CCTGCCACGCGCTTGATGCCCCCGGGGCAGGAGGAGGTTCATGATCCTTACTTACTCCTA GCTTCGTAATTAGGTTCAACTTTTCCAGTTCCAGAGTCACGGTTCGACCGAGATTCCGGG GAGAGTGAAGAAGCAGAGGAAGAAGTGGGTGAGGGAACGCCGCAGAGCAGCGCCCTGACA GAGGGCGACTATGTGCCCGACTCCCCTGCCCTGTTGCCCATCGAGCTCAAGCAGGAGCTG CCCAAGTACCTGCCGGCCCTGCAGGTCAGGCCCTCCCCTCGCCCCGGGCCGCTGTCCGCA TTGGCAGTCGGAGTTACCACAGGGGCTGAGCGAAGCCTGGCCCCCGTGTTGGCGTCTGTC GCCTCACAGGGCTGCTGGGCCCACTGGGGCAGTGACGGGCGGGCACAGCCACTGGCCCCT CATGCTTCTAGGTCCCGCCTCTTTCTCATGCTGGACGGAACTGGGTGGACAGGGAGCTGC CCGCAGGACTGCTCTGCGGCTTGAAAGGCAGCCTGGGCGTGCGGCCGCGCTGCTGTCACT GCTGCCCGAGTTGCGTCCTCCTCCGCACTGGAGAGCAGTGCCTTCCACTTGACCCCTGCG TGGGCGGGTTATGTAGGCACCAAGGCCTTGTTACCGGCATCTGTGCAGGGCTTGGATGGG GGAGCGGCTACGGGAGTCAGTGTAGATGTGTGACCAGAAGCCTTTTGCTCAGGCAGCTAT CAATAAGGCAGGATATTGTTGGGAGTGATTTGGAAGGGACAAGCCTGAGAAGGTACCAGT GGCCTCGGGGGCCTGGGAGACCGGCAGGGACTCGGCCCCCTCCTTGGTGCCTGTGGGCGG AGAGGTTCTCTCTGGCGCATGCAGCAGGCCTCTGTCGACTGCCCTATGCCTTGTGAGCGC CTCTGCCCCTTAGTGCTGCTGAGCGTAGGCGTCGGGCCACAGGCCACCCAGAGTACGTGA CATCCGGCCTGGGCACCGGCCCCAAGGTACACCGAGGGGTAGGTGCCCTGGCATGGGGCA TCATGCTGCGCCTGGCAGGTAGGGCCCGTCCTCAGTGTCATCCTGGTACAAGCAGGGGAC ACATCCACTTTGACAGAGAGACTCTCCGGATGGCCTTTTTTTTGGAGACTGGGTCTGTCT CTGTCATCCAGGCTGGAGTGGAGTGGCTTAATCATAGCTCACTGGAGCCTCCACCTCCCA GGCTCAAACAATCCTCCCATCTCAGCCTCCTGAGTAGCTGGAACTACAGGCGCAAGCCAC CATGCCTGGCTAATTTTTTTATTTTGTAGAGAAGAGTTTTGGCCAGGCACAGTGGCTCAC GCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGTGGGCGGATCAGAGGTCAGGAGTTC GAGACCAGCCTGGCCAATATGGTGAAATCCTGTCTCTACTAAAAATACAAAAATTAGCCT GGCGTGGTGGTGCGTACCTATACTCCCAGCTACTAGGGAGGCTGAGGCAGGAGAATCGCC TGAACCCAGGAGGTGGAGGTTGCAGTGAGCCGAGATCTCACCATTGCACTCCAGCCTGGG TGACAGAGCGAGACTCCATCTCAAAAAGAAAAAAAGAAAACAGAGTGTTGCTATGTTGGC CAGGCTGGTCTTGAACTCCTGGGCTCAAGCAATCCTCCTGCCTTGCCCTCCCAAAGTGCT GGAATTACAGGCCTGAGCCCTTGCACCTGGCTGGGATGGCCTTTTGTTCACACTGGTTTT GTTTCATAATAAAGTGTCAGATGGTTTTGCAAGGAAAGAGACTTTGAAAGAACTGAGCTG CTCCCAGCTCCACCCCCGGCCCAGTCCCAAGGCTCTGCCCTGCACCTGCCCCGTGCTGGG TGTGCCGTGCCTGTGGACGCAGCCGCCCTCCCTCCAGCTGGCATGGCCACTGAGACCTCA CACAGGCGCTTCCTTCCCAGGGCTGCCGGAGCGTCGAGGAGTTCCAGTGCCTGAACAGGA TCGAGGAGGGCACCTATGGAGTGGTCTACAGAGCAAAAGACAAGAAAACAGGTGGGTGGG GTCCCCTCACCCCACAAAGGCAGGGGAAGTGGGGCAGGGGCTGGCTGCCCGAGAGCTGCG ACTGCACCTGGGCCCGCTTCACCTGAGCAGCTACTGGAGGTTGGACCCCTCAGCACCTCT AGAAGCCAGAGGTCAGCCTGGCCCTGGGGCTTTGCCACTCCCTTGCAGTAGCAGGCGGCC TGCCCCACAGGGCCGAGGCCCAGCGCGTGGAGTGGTCTGTGCCGGGGCTGGTGTGCAGGT TTGCGTTCCCAGCGTCCCACCCAAGCAGGTGTGTGAGCCGGGAACTCTGTTGGGAGTCGG CCACTGGGATCCCAGGTGAGGCCGGCTCTGTTGGGGAAGTCGATGTGGAGTCGGCGTGGC CGCTGGGATCCCAGGTGGCTGTAGGTGGCTGTGAGTGTCTGTGGTGTGTTGAGTGGGAAG CCGTGGGTGTTGCCGAGACCTCAGCTGGGGCGTTCTCCTGGTGCCCACGTGCCCCCACCT AGAACGAGACCCCCCTCCGTGAAATGCTGGCGCTTTGGGCACTGCCTGCGGTCCTCACTG AACGAGTCCACTGTTGGTACCGTGACTTTGAGAATGCCTCTCAGTGCCGTCTGTATTTTC TTCACAGATGAAATTGTGGCTCTAAAGCGGCTGAAGATGGAGAAGGAGAAGGAGGGCTTC CCGATCACGTCCCTGAGGGAGATCAACACCATCCTCAAGGCCCAGCATCCCAACATTGTC ACCGTTAGAGTGAGCATGGCCCCACCACGCCTGGCCCCGGGTGGAAGGCTTTTCCGACAG GGCCCCGTGCTGTCCTGGGGCCGGGTGCTTCCTACACTCTCCTGCACTTAGTGGAGCCCT TCACAGACCACACAGAAGCAAGTATTTGCCTCCCGGGTGGCACCGGAGGTCCTTACTGTC CCTCAGCATCTGCGCCCGGGTGCAGGGGTGGGTGGGGGCCTGGAGGTGCCCAGCACCCAC AGAGCCGTGCCCTGCAGGAGATTGTGGTGGGCAGCAACATGGACAAGATCTACATCGTGA TGAACTACGTGGAGCACGACCTCAAGAGCCTGATGGAGACCATGAAACAGCCCTTCCTGC CAGGTACAGCCGCGCCCCGGGGTCCTGTCTGCGTACAAGTGGGGGCAGTGTCCTGGTCAC CCCCGCGGTGACAGTGCTGCAGGGAGGGCCAGCTGCATCCACAGGGAAAGCCCTGAGAAG CCTCTGTTGCTGCCGAGGCGAGCGGGCCACCCTGAGTGCCCTGGGCTTGGGGCGGCCGGG TCCACATGGGAGCCTCCCTCCCTCCCAGGGGAGGTGAAGACCCTGATGATCCAGCTGCTG CGGGGGGTGAAACACCTGCACGACAACTGGATCCTGCACCGTGACCTCAAGACGTCCAAC CTGCTGCTGAGCCACGCCGGCATCCTCAAGGTGAGCCCCCCTCCGAGTGGCCCATCCCAG GGTGACCCGCCCAGGCCCACCCACAGCCGCCCATCTGTCGTTGCAGGTGGGTGATTTTGG GCTGGCGCGGGAGTACGGATCCCCTCTGAAGGCCTACACCCCGGTCGTGGTGACCCAGTG GTACCGCGCCCCAGAGCTGCTGCTTGGTGCCAAGGTGAGTCCTGGGCGTCTGAGTGCCTC CCCTGTCCCCCATGCAGCCTCCCACAGCTTCGCGGGCACTGGCCTTCCTGAACACCTCTC CTGGCGTCTTAGGAATACTCCACGGCCGTGGACATGTGGTCAGTGGGCTGCATCTTCGGG GAGCTGCTGACTCAGAAGCCTCTGTTCCCCGGGAATTCGGAAATCGATCAGATCAACAAA GTGTTCAAGGTGGGTCTGGCCCTGCCGCAGGTGCGCTATGGATTTCAGAGGAGTTGCAGG AATGGGGCTGCGGGGCGCACAGGTGCTGGGTTGAGATGGGGACCAGGGCCACTGAGAGCC CTCCTGGTGGCTTGTCTTCTCTGACGGGACACAGGTGCCAACACTGTGGGCCACTTGGTG TGGCTGTTGAAGCACCTCTGTCTTTCAGGAGCTGGGGACCCCCAGTGAGAAAATCTGGCC CGGCTACAGTGAGCTCCCAGTAGTCAAAAAGATGACCTTCAGCGAGCACCCCTACAACAA CCTCCGCAAGCGCTTCGGGGCTCTGCTCTCAGACCAGGGCTTCGACCTCATGAACAAGTG AGCCCAGTGCAGCCGGGTGGCGGGAGGTCCCGAGCCATAGCGGTGACTTCCCAGTCCCAG GCCTACCTGCTGGCTCACCACGTTCCAGAACTGCTCTGGTGCCTGGCGTCCCATGCCCTG AGCCCCGTCCCAACACAGCCCATCTTTGGGGGACCCAGTGGAGCACACGAGCACCTCCTG GGCCTCTGGCCCTCTCCCCCCAGGTTCCTGACCTACTTCCCCGGGAGGAGGATCAGCGCT GAGGACGGCCTCAAGCATGAGTATTTCCGCGAGACCCCCCTCCCCATCGACCCCTCCATG TTCCCCACGTGGCCCGCCAAGAGCGAGCAGCAGCGTGTGAAGCGGGGCACCAGCCCGAGG CCCCCTGAGGGAGGCCTGGGCTACAGCCAGCTGGTGAGGGGCCTGGCGGGTGGGGCGTGC CCACAGGTGGGGCTGGCTTGGGCAGGGTTCTCACGGTAGCCGACTCGTCCCAGGGTGACG ACGACCTGAAGGAGACGGGCTTCCACCTTACCACCACGAACCAGGGGGCCTCTGCCGCGG GCCCCGGCTTCAGCCTCAAGTTCTGAAGGTCAGAGTGGACCCCGTCATGGGGAGAACTCA GCCGGGACCACAGGCGTGGCTACTGCGGCTGGAGCTGCGATGAGACTCGGAACTCCTCGT CTTACTTTGTGCTCCATGTTTTGTTTTTGTATTTTGGTTTGTAAATTTGTAGAATTAAAT CATTTTCCTTGTTGTGGAGGAAA OMIM ID 116951